PAGE 1
000 B000000 12/31/2007
000 C000000 0001227476
000 D000000 N
000 E000000 NF
000 F000000 Y
000 G000000 N
000 H000000 N
000 I000000 6.1
000 J000000 A
001 A000000 NUVEEN MULTI-STRATEGY INCOME & GROWTH FUND 2
001 B000000 811-21333
001 C000000 3129178200
002 A000000 333 WEST WACKER DRIVE
002 B000000 CHICAGO
002 C000000 IL
002 D010000 60606
002 D020000 1286
003 000000 N
004 000000 N
005 000000 N
006 000000 N
007 A000000 N
007 B000000 0
007 C010100 1
007 C010200 2
007 C010300 3
007 C010400 4
007 C010500 5
007 C010600 6
007 C010700 7
007 C010800 8
007 C010900 9
007 C011000 10
007 C011100 11
007 C011200 12
007 C011300 13
007 C011400 14
007 C011500 15
007 C011600 16
007 C011700 17
007 C011800 18
007 C011900 19
007 C012000 20
007 C012100 21
007 C012200 22
007 C012300 23
007 C012400 24
007 C012500 25
007 C012600 26
007 C012700 27
007 C012800 28
PAGE 2
007 C012900 29
007 C013000 30
007 C013100 31
007 C013200 32
007 C013300 33
007 C013400 34
007 C013500 35
007 C013600 36
007 C013700 37
007 C013800 38
007 C013900 39
007 C014000 40
007 C014100 41
007 C014200 42
007 C014300 43
007 C014400 44
007 C014500 45
007 C014600 46
007 C014700 47
007 C014800 48
007 C014900 49
007 C015000 50
008 A000001 NUVEEN ASSET MANAGEMENT
008 B000001 A
008 C000001 801-14147
008 D010001 CHICAGO
008 D020001 IL
008 D030001 60606
008 D040001 1286
008 A000002 SPECTRUM ASSET MANAGEMENT, INC.
008 B000002 S
008 C000002 801-30405
008 D010002 STAMFORD
008 D020002 CT
008 D030002 06905
008 A000003 TRADEWINDS GLOBAL INVESTORS, LLC.
008 B000003 S
008 C000003 801-65208
008 D010003 LOS ANGELES
008 D020003 CA
008 D030003 90067
008 A000004 SYMPHONY ASSET MANAGEMENT, LLC.
008 B000004 S
008 C000004 801-52638
008 D010004 SAN FRANCISCO
008 D020004 CA
008 D030004 94104
012 A000001 EQUISERVE INC.
012 B000001 84-05925
012 C010001 PROVIDENCE
012 C020001 RI
PAGE 3
012 C030001 02940
013 A000001 ERNST & YOUNG LLP
013 B010001 CHICAGO
013 B020001 IL
013 B030001 60606
014 A000001 NUVEEN INVESTMENTS, LLC
014 B000001 8-13464
014 A000002 SPECTRUM ASSET MANAGEMENT, INC.
014 B000002 8-36472
014 A000003 DELETE
014 A000004 DELETE
015 A000001 STATE STREET BANK AND TRUST COMPANY
015 B000001 C
015 C010001 BOSTON
015 C020001 MA
015 C030001 02110
015 E010001 X
018 000000 Y
019 A000000 Y
019 B000000 184
019 C000000 NUVEENFUND
020 A000001 SPECTRUM ASSET MANAGEMENT, INC.
020 B000001 06-1209521
020 C000001 654
020 A000002 BEAR STEARNS
020 B000002 13-3604093
020 C000002 321
020 A000003 GOLDMAN SACHS
020 B000003 13-5108880
020 C000003 130
020 A000004 MERRILL LYNCH
020 B000004 13-5674085
020 C000004 94
020 A000005 CITIGROUP
020 B000005 13-3214963
020 C000005 61
020 A000006 INVESTMENT TECHNOLOGY
020 B000006 13-3757717
020 C000006 60
020 A000007 JEFFERIES & CO
020 B000007 95-2622900
020 C000007 59
020 A000008 ITG INC
020 B000008 95-2848406
020 C000008 41
020 A000009 LEHMAN BROTHERS INC
020 B000009 13-2518466
020 C000009 41
020 A000010 MORGAN STANLEY
020 B000010 13-2655998
020 C000010 29
PAGE 4
021 000000 1649
022 A000001 SPECTRUM ASSET MANAGEMENT, INC.
022 B000001 06-1209521
022 C000001 411329
022 D000001 280468
022 A000002 GOLDMAN SACHS
022 B000002 13-5108880
022 C000002 176348
022 D000002 326122
022 A000003 UBS
022 B000003 13-2638166
022 C000003 91740
022 D000003 224515
022 A000004 ITG
022 B000004 95-2848406
022 C000004 168153
022 D000004 125728
022 A000005 BEAR STEARNS
022 B000005 13-3604093
022 C000005 166150
022 D000005 82004
022 A000006 MERRILL LYNCH
022 B000006 13-5674085
022 C000006 151281
022 D000006 49655
022 A000007 CITIGROUP
022 B000007 13-3214963
022 C000007 85584
022 D000007 99069
022 A000008 BANK OF AMERICA
022 B000008 56-2058405
022 C000008 64575
022 D000008 109643
022 A000009 DEUTSCHE BANK
022 B000009 13-2730828
022 C000009 54103
022 D000009 119352
022 A000010 MORGAN STANLEY
022 B000010 13-2655998
022 C000010 80440
022 D000010 74721
023 C000000 2040965
023 D000000 1929282
024 000000 N
025 D000001 0
025 D000002 0
025 D000003 0
025 D000004 0
025 D000005 0
025 D000006 0
025 D000007 0
PAGE 5
025 D000008 0
026 A000000 N
026 B000000 N
026 C000000 N
026 D000000 Y
026 E000000 N
026 F000000 N
026 G010000 N
026 G020000 N
026 H000000 N
027 000000 N
028 A010000 0
028 A020000 0
028 A030000 0
028 A040000 0
028 B010000 0
028 B020000 0
028 B030000 0
028 B040000 0
028 C010000 0
028 C020000 0
028 C030000 0
028 C040000 0
028 D010000 0
028 D020000 0
028 D030000 0
028 D040000 0
028 E010000 0
028 E020000 0
028 E030000 0
028 E040000 0
028 F010000 0
028 F020000 0
028 F030000 0
028 F040000 0
028 G010000 0
028 G020000 0
028 G030000 0
028 G040000 0
028 H000000 0
030 A000000 0
030 B000000 0.00
030 C000000 0.00
031 A000000 0
031 B000000 0
032 000000 0
033 000000 0
035 000000 0
036 B000000 0
038 000000 0
042 A000000 0
PAGE 6
042 B000000 0
042 C000000 0
042 D000000 0
042 E000000 0
042 F000000 0
042 G000000 0
042 H000000 0
043 000000 0
044 000000 0
045 000000 Y
046 000000 N
047 000000 N
048 000000 0.000
048 A010000 0
048 A020000 0.000
048 B010000 0
048 B020000 0.000
048 C010000 0
048 C020000 0.000
048 D010000 0
048 D020000 0.000
048 E010000 0
048 E020000 0.000
048 F010000 0
048 F020000 0.000
048 G010000 0
048 G020000 0.000
048 H010000 0
048 H020000 0.000
048 I010000 0
048 I020000 0.000
048 J010000 0
048 J020000 0.000
048 K010000 0
048 K020000 0.000
049 000000 N
050 000000 N
051 000000 N
052 000000 Y
053 A000000 Y
053 B000000 Y
053 C000000 N
054 A000000 Y
054 B000000 N
054 C000000 N
054 D000000 N
054 E000000 N
054 F000000 N
054 G000000 N
054 H000000 Y
054 I000000 N
PAGE 7
054 J000000 Y
054 K000000 N
054 L000000 N
054 M000000 Y
054 N000000 N
054 O000000 Y
055 A000000 N
055 B000000 N
056 000000 Y
057 000000 N
058 A000000 N
059 000000 Y
060 A000000 Y
060 B000000 Y
061 000000 0
062 A000000 N
062 B000000 0.0
062 C000000 0.0
062 D000000 0.0
062 E000000 0.0
062 F000000 0.0
062 G000000 0.0
062 H000000 0.0
062 I000000 0.0
062 J000000 0.0
062 K000000 0.0
062 L000000 0.0
062 M000000 0.0
062 N000000 0.0
062 O000000 0.0
062 P000000 0.0
062 Q000000 0.0
062 R000000 0.0
063 A000000 0
063 B000000 0.0
066 A000000 Y
066 B000000 N
066 C000000 N
066 D000000 N
066 E000000 Y
066 F000000 N
066 G000000 N
067 000000 N
068 A000000 N
068 B000000 N
069 000000 N
070 A010000 Y
070 A020000 Y
070 B010000 Y
070 B020000 Y
070 C010000 Y
PAGE 8
070 C020000 N
070 D010000 Y
070 D020000 N
070 E010000 Y
070 E020000 N
070 F010000 Y
070 F020000 N
070 G010000 Y
070 G020000 N
070 H010000 Y
070 H020000 N
070 I010000 N
070 I020000 N
070 J010000 Y
070 J020000 N
070 K010000 Y
070 K020000 Y
070 L010000 Y
070 L020000 N
070 M010000 Y
070 M020000 N
070 N010000 Y
070 N020000 N
070 O010000 Y
070 O020000 Y
070 P010000 N
070 P020000 N
070 Q010000 N
070 Q020000 N
070 R010000 Y
070 R020000 Y
071 A000000 2081452
071 B000000 2216974
071 C000000 2666787
071 D000000 78
072 A000000 12
072 B000000 81866
072 C000000 74455
072 D000000 0
072 E000000 0
072 F000000 24113
072 G000000 0
072 H000000 0
072 I000000 65
072 J000000 596
072 K000000 367
072 L000000 734
072 M000000 73
072 N000000 0
072 O000000 0
072 P000000 0
PAGE 9
072 Q000000 0
072 R000000 32
072 S000000 125
072 T000000 0
072 U000000 0
072 V000000 0
072 W000000 3055
072 X000000 29160
072 Y000000 9339
072 Z000000 136500
072AA000000 70490
072BB000000 0
072CC010000 0
072CC020000 255870
072DD010000 111173
072DD020000 0
072EE000000 41701
073 A010000 0.7912
073 A020000 0.0000
073 B000000 0.3000
073 C000000 0.0500
074 A000000 17546
074 B000000 76140
074 C000000 10987
074 D000000 538212
074 E000000 806008
074 F000000 705924
074 G000000 0
074 H000000 0
074 I000000 556558
074 J000000 6306
074 K000000 0
074 L000000 17088
074 M000000 1040
074 N000000 2735809
074 O000000 4135
074 P000000 1191
074 Q000000 0
074 R010000 0
074 R020000 12426
074 R030000 10760
074 R040000 1345
074 S000000 965000
074 T000000 1740952
074 U010000 139770
074 U020000 0
074 V010000 12.46
074 V020000 0.00
074 W000000 0.0000
074 X000000 367
074 Y000000 582989
PAGE 10
075 A000000 0
075 B000000 1952658
076 000000 11.00
077 A000000 Y
077 C000000 Y
077 D000000 Y
077 Q010000 Y
078 000000 N
080 A000000 CHUBB GROUP OF INSURANCE COMPANIES
080 B000000 AIG, GREAT AMERICAN, ST.PAUL & CNA
080 C000000 110000
081 A000000 Y
081 B000000 183
082 A000000 N
082 B000000 0
083 A000000 N
083 B000000 0
084 A000000 N
084 B000000 0
085 A000000 Y
085 B000000 N
086 A010000 0
086 A020000 0
086 B010000 726
086 B020000 7872
086 C010000 0
086 C020000 0
086 D010000 0
086 D020000 0
086 E010000 0
086 E020000 0
086 F010000 0
086 F020000 0
087 A010000 COMMON STOCK
087 A020000 67073D102
087 A030000 JQC
088 A000000 N
088 B000000 N
088 C000000 N
088 D000000 Y
SIGNATURE STEPHEN D. FOY
TITLE V.P & CONTROLLER