SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   FORM 8-K/A

                        AMENDMENT NO. 2 TO CURRENT REPORT

     Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934


Date of Report (Date of earliest event reported): March 20, 2002 (March 6, 2002)
                                                 -------------------------------


                           Introgen Therapeutics, Inc.
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             (Exact name of registrant as specified in its charter)

         Delaware                      0-21291                   74-2704230
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(State or other jurisdiction         (Commission                (IRS Employer
     of incorporation)               File Number)            Identification No.)

                 301 Congress Avenue, Suite 1850, Austin, Texas     78701
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                    (Address of principal executive offices)      (Zip Code)


Registrant's telephone number, including area code:   (512) 708-9310
                                                   -----------------------------


          -------------------------------------------------------------
          (Former name or former address, if changed since last report)





ITEM 4.  CHANGES IN REGISTRANT'S CERTIFYING ACCOUNTANT.

         Item 4 of Amendment No. 1 to the Current Report on Form 8-K/A filed by
the Registrant on March 18, 2002 is hereby amended and restated in its entirety
as follows:

         (a) (i) On March 6, 2002, Introgen Therapeutics, Inc. (the "Company")
dismissed Arthur Andersen LLP as its independent public accountant, effective
upon completion of Arthur Andersen LLP's services in connection with the filing
of the Company's Annual Report on Form 10-K for the six-month transition period
ended December 31, 2001.

             (ii) Arthur Andersen LLP's reports on the Company's financial
statements for each of the years ended June 30, 2000 and 2001 and the six-month
transition period ended December 31, 2001 did not contain an adverse opinion or
a disclaimer of opinion, and were not qualified or modified as to uncertainty,
audit scope, or accounting principles.

             (iii) The decision to change independent public accountants was
recommended by the Audit Committee of the Company's Board of Directors and was
approved by the Company's Board of Directors.

             (iv) During each of the two years ended June 30, 2000 and 2001,
the six-month transition period ended December 31, 2001, and through March 20,
2002, there were no disagreements with Arthur Andersen LLP on any matter of
accounting principles or practices, financial statement disclosure, or auditing
scope or procedures, which disagreements, if not resolved to the satisfaction of
Arthur Andersen LLP, would have caused it to make reference to the subject
matter of the disagreement in connection with its report.

             (v) During each of the two years ended June 30, 2000 and 2001 and
the six-month transition period ended December 31, 2001, Arthur Andersen LLP did
not advise the Company of any "reportable events" as described in Item
304(a)(1)(v) of Regulation S-K under the Securities Act of 1933, as amended.

         (b) (i) On March 6, 2002, the Company engaged Ernst & Young LLP ("E&Y")
as its principal accountant to audit the Company's financial statements.

             (ii) During each of the two years ended June 30, 2000 and 2001 and
for the six-month transition period ended December 31, 2001, the Company did not
consult E&Y on any matters described in Item 304(a)(2)(i) of Regulation S-K.

             (iii) During each of the two years ended June 30, 2000 and 2001
and for the six-month transition period ended December 31, 2001, the Company did
not consult E&Y on any matters described in Item 304(a)(2)(ii) of Regulation
S-K.




         (c) The Company requested Arthur Andersen LLP to furnish a letter
addressed to the Commission, stating whether it agrees with the statements made
by the Company herein and, if not, stating the respects in which it does not
agree. A copy of this letter, dated as of March 20, 2002, is filed as Exhibit
16.1 to this Form 8-K.








ITEM 7.    EXHIBITS



   EXHIBIT NO.          DESCRIPTION
   -----------          -----------
                     
      16.1              Letter re: Change in Certifying Accountant






                                   SIGNATURES


         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


Dated:   March 20, 2002                  INTROGEN THERAPEUTICS, INC.



                                         /s/ James W. Albrecht, Jr.
                                         ---------------------------------------
                                         James W. Albrecht, Jr.
                                         Chief Financial Officer






                                 EXHIBIT INDEX



   EXHIBIT NO.          DESCRIPTION
   -----------          -----------
                     
      16.1              Letter re: Change in Certifying Accountant