SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                   Under the Securities Exchange Act of 1934
                               (Amendment No. 2)*

                      Take-Two Interactive Software, Inc.
                                (Name of Issuer)

                         Common Stock, Par Value $0.01
                         (Title of Class of Securities)

                                   874054109
                                 (CUSIP Number)

                                  Marc Weitzen
                                Icahn Capital LP
                          767 Fifth Avenue, 47th Floor
                            New York, New York 10153
                                 (212) 702-4300

                 (Name, Address and Telephone Number of Person
               Authorized to Receive Notices and Communications)

                                January 28, 2010
            (Date of Event which Requires Filing of this Statement)

If  the filing person has previously filed a statement on Schedule 13G to report
the  acquisition  that  is  the subject of this Schedule 13D, and is filing this
schedule  because  of  Section 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check
the  following  box  /  /.

NOTE:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See Rule 13d-7 for other parties
to  whom  copies  are  to  be  sent.

*The  remainder  of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent  amendment  containing  information  which  would  alter
disclosures  provided  in  a  prior  cover  page.

The information required on the remainder of this cover page shall not be deemed
to  be  "filed"  for the purpose of Section 18 of the Securities Exchange Act of
1934  ("Act") or otherwise subject to the liabilities of that section of the Act
but  shall  be  subject  to  all  other  provisions of the Act (however, see the
Notes).



                                  SCHEDULE 13D

CUSIP No. 874054109

1   NAME  OF  REPORTING  PERSON
      High  River  Limited  Partnership

2   CHECK  THE  APPROPRIATE  BOX  IF  A  MEMBER  OF  A  GROUP
      (a) / /
      (b) / /

3   SEC  USE  ONLY

4   SOURCE  OF  FUNDS
      WC

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
      2(d)  or  2(e)                                                         / /

6   CITIZENSHIP  OR  PLACE  OF  ORGANIZATION
      Delaware

NUMBER  OF  SHARES  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON  WITH:

7   SOLE  VOTING  POWER
      2,042,709

8   SHARED  VOTING  POWER
      0

9   SOLE  DISPOSITIVE  POWER
      2,042,709

10  SHARED  DISPOSITIVE  POWER
      0

11  AGGREGATE  AMOUNT  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON
      2,042,709

12  CHECK BOX  IF  THE  AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES / /

13  PERCENT  OF  CLASS  REPRESENTED  BY  AMOUNT  IN  ROW  (11)
      2.46%

14  TYPE  OF  REPORTING  PERSON
      PN



                                  SCHEDULE 13D

CUSIP No. 874054109

1   NAME  OF  REPORTING  PERSON
      Hopper  Investments  LLC

2   CHECK  THE  APPROPRIATE  BOX  IF  A  MEMBER  OF  A  GROUP
      (a) / /
      (b) / /

3   SEC  USE  ONLY

4   SOURCE  OF  FUNDS
      WC

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
    2(d)  or  2(e)                                                           / /

6   CITIZENSHIP  OR  PLACE  OF  ORGANIZATION
      Delaware

NUMBER  OF  SHARES  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON  WITH:

7   SOLE  VOTING  POWER
      0

8   SHARED  VOTING  POWER
      2,042,709

9   SOLE  DISPOSITIVE  POWER
      0

10  SHARED  DISPOSITIVE  POWER
      2,042,709

11  AGGREGATE  AMOUNT  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON
      2,042,709

12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES    / /

13  PERCENT  OF  CLASS  REPRESENTED  BY  AMOUNT  IN  ROW  (11)
      2.46%

14  TYPE  OF  REPORTING  PERSON
      OO



                                  SCHEDULE 13D

CUSIP No. 874054109

1   NAME  OF  REPORTING  PERSON
      Barberry  Corp.

2   CHECK  THE  APPROPRIATE  BOX  IF  A  MEMBER  OF  A  GROUP
      (a) / /
      (b) / /

3   SEC  USE  ONLY

4   SOURCE  OF  FUNDS
      WC

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
    2(d)  or  2(e)                                                           / /

6   CITIZENSHIP  OR  PLACE  OF  ORGANIZATION
      Delaware

NUMBER  OF  SHARES  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON  WITH:

7   SOLE  VOTING  POWER
      0

8   SHARED  VOTING  POWER
      2,042,709

9   SOLE  DISPOSITIVE  POWER
      0

10  SHARED  DISPOSITIVE  POWER
      2,042,709

11  AGGREGATE  AMOUNT  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON
      2,042,709

12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES    / /

13  PERCENT  OF  CLASS  REPRESENTED  BY  AMOUNT  IN  ROW  (11)
      2.46%

14  TYPE  OF  REPORTING  PERSON
      CO




                                  SCHEDULE 13D

CUSIP No. 874054109

1   NAME  OF  REPORTING  PERSON
      Icahn  Partners  Master  Fund  LP

2   CHECK  THE  APPROPRIATE  BOX  IF  A  MEMBER  OF  A  GROUP
      (a) / /
      (b) / /

3   SEC  USE  ONLY

4   SOURCE  OF  FUNDS
      WC

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
    2(d)  or  2(e)                                                           / /

6   CITIZENSHIP  OR  PLACE  OF  ORGANIZATION
      Cayman  Islands

NUMBER  OF  SHARES  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON  WITH:

7   SOLE  VOTING  POWER
      3,336,248

8   SHARED  VOTING  POWER
      0

9   SOLE  DISPOSITIVE  POWER
      3,336,248

10  SHARED  DISPOSITIVE  POWER
      0

11  AGGREGATE  AMOUNT  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON
      3,336,248

12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES    / /

13  PERCENT  OF  CLASS  REPRESENTED  BY  AMOUNT  IN  ROW  (11)
      4.01%

14  TYPE  OF  REPORTING  PERSON
      PN



                                  SCHEDULE 13D

CUSIP No. 874054109

1   NAME  OF  REPORTING  PERSON
      Icahn  Partners  Master  Fund  II  LP

2   CHECK  THE  APPROPRIATE  BOX  IF  A  MEMBER  OF  A  GROUP
      (a) / /
      (b) / /

3   SEC  USE  ONLY

4   SOURCE  OF  FUNDS
      WC

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
    2(d)  or  2(e)                                                           / /

6   CITIZENSHIP  OR  PLACE  OF  ORGANIZATION
      Cayman  Islands

NUMBER  OF  SHARES  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON  WITH:

7   SOLE  VOTING  POWER
      1,353,896

8   SHARED  VOTING  POWER
      0

9   SOLE  DISPOSITIVE  POWER
      1,353,896

10  SHARED  DISPOSITIVE  POWER
      0

11  AGGREGATE  AMOUNT  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON
      1,353,896

12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES    / /

13  PERCENT  OF  CLASS  REPRESENTED  BY  AMOUNT  IN  ROW  (11)
      1.63%

14  TYPE  OF  REPORTING  PERSON
      PN



                                  SCHEDULE 13D

CUSIP No. 874054109

1   NAME  OF  REPORTING  PERSON
      Icahn  Partners  Master  Fund  III  LP

2   CHECK  THE  APPROPRIATE  BOX  IF  A  MEMBER  OF  A  GROUP
      (a) / /
      (b) / /

3   SEC  USE  ONLY

4   SOURCE  OF  FUNDS
      WC

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
    2(d)  or  2(e)                                                           / /

6   CITIZENSHIP  OR  PLACE  OF  ORGANIZATION
      Cayman  Islands

NUMBER  OF  SHARES  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON  WITH:

7   SOLE  VOTING  POWER
      512,118

8   SHARED  VOTING  POWER
      0

9   SOLE  DISPOSITIVE  POWER
      512,118

10  SHARED  DISPOSITIVE  POWER
      0

11  AGGREGATE  AMOUNT  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON
      512,118

12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES    / /

13  PERCENT  OF  CLASS  REPRESENTED  BY  AMOUNT  IN  ROW  (11)
      0.62%

14  TYPE  OF  REPORTING  PERSON
      PN



                                  SCHEDULE 13D

CUSIP No. 874054109

1   NAME  OF  REPORTING  PERSON
      Icahn  Offshore  LP

2   CHECK  THE  APPROPRIATE  BOX  IF  A  MEMBER  OF  A  GROUP
      (a) / /
      (b) / /

3   SEC  USE  ONLY

4   SOURCE  OF  FUNDS

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
    2(d)  or  2(e)                                                           / /

6   CITIZENSHIP  OR  PLACE  OF  ORGANIZATION
      Delaware

NUMBER  OF  SHARES  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON  WITH:

7   SOLE  VOTING  POWER
      0

8   SHARED  VOTING  POWER
      5,202,262

9   SOLE  DISPOSITIVE  POWER
      0

10  SHARED  DISPOSITIVE  POWER
      5,202,262

11  AGGREGATE  AMOUNT  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON
      5,202,262

12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES    / /

13  PERCENT  OF  CLASS  REPRESENTED  BY  AMOUNT  IN  ROW  (11)
      6.25%

14  TYPE  OF  REPORTING  PERSON
      PN



                                  SCHEDULE 13D

CUSIP No. 874054109

1   NAME  OF  REPORTING  PERSON
      Icahn  Partners  LP

2   CHECK  THE  APPROPRIATE  BOX  IF  A  MEMBER  OF  A  GROUP
      (a) / /
      (b) / /

3   SEC  USE  ONLY

4   SOURCE  OF  FUNDS
      WC

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
    2(d)  or  2(e)                                                           / /

6   CITIZENSHIP  OR  PLACE  OF  ORGANIZATION
      Delaware

NUMBER  OF  SHARES  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON  WITH:

7   SOLE  VOTING  POWER
      2,968,581

8   SHARED  VOTING  POWER
      0

9   SOLE  DISPOSITIVE  POWER
      2,968,581

10  SHARED  DISPOSITIVE  POWER
      0

11  AGGREGATE  AMOUNT  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON
      2,968,581

12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES    / /

13  PERCENT  OF  CLASS  REPRESENTED  BY  AMOUNT  IN  ROW  (11)
      3.57%

14  TYPE  OF  REPORTING  PERSON
      PN



                                  SCHEDULE 13D

CUSIP No. 874054109

1   NAME  OF  REPORTING  PERSON
      Icahn  Onshore  LP

2   CHECK  THE  APPROPRIATE  BOX  IF  A  MEMBER  OF  A  GROUP
      (a) / /
      (b) / /

3   SEC  USE  ONLY

4   SOURCE  OF  FUNDS

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
    2(d)  or  2(e)                                                           / /

6   CITIZENSHIP  OR  PLACE  OF  ORGANIZATION
      Delaware

NUMBER  OF  SHARES  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON  WITH:

7   SOLE  VOTING  POWER
      0

8   SHARED  VOTING  POWER
      2,968,581

9   SOLE  DISPOSITIVE  POWER
      0

10  SHARED  DISPOSITIVE  POWER
      2,968,581

11  AGGREGATE  AMOUNT  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON
      2,968,581

12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES    / /

13  PERCENT  OF  CLASS  REPRESENTED  BY  AMOUNT  IN  ROW  (11)
      3.57%

14  TYPE  OF  REPORTING  PERSON
      PN



                                  SCHEDULE 13D

CUSIP No. 874054109

1   NAME  OF  REPORTING  PERSON
      Icahn  Capital  LP

2   CHECK  THE  APPROPRIATE  BOX  IF  A  MEMBER  OF  A  GROUP
      (a) / /
      (b) / /

3   SEC  USE  ONLY

4   SOURCE  OF  FUNDS
      WC

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
    2(d)  or  2(e)                                                           / /

6   CITIZENSHIP  OR  PLACE  OF  ORGANIZATION
      Delaware

NUMBER  OF  SHARES  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON  WITH:

7   SOLE  VOTING  POWER
      0

8   SHARED  VOTING  POWER
      8,170,843

9   SOLE  DISPOSITIVE  POWER
      0

10  SHARED  DISPOSITIVE  POWER
      8,170,843

11  AGGREGATE  AMOUNT  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON
      8,170,843

12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES    / /

13  PERCENT  OF  CLASS  REPRESENTED  BY  AMOUNT  IN  ROW  (11)
      9.82%

14  TYPE  OF  REPORTING  PERSON
      PN



                                  SCHEDULE 13D

CUSIP No. 874054109

1   NAME  OF  REPORTING  PERSON
      IPH  GP  LLC

2   CHECK  THE  APPROPRIATE  BOX  IF  A  MEMBER  OF  A  GROUP
      (a) / /
      (b) / /

3   SEC  USE  ONLY

4   SOURCE  OF  FUNDS
      WC

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
    2(d)  or  2(e)                                                           / /

6   CITIZENSHIP  OR  PLACE  OF  ORGANIZATION
      Delaware

NUMBER  OF  SHARES  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON  WITH:

7   SOLE  VOTING  POWER
      0

8   SHARED  VOTING  POWER
      8,170,843

9   SOLE  DISPOSITIVE  POWER
      0

10  SHARED  DISPOSITIVE  POWER
      8,170,843

11  AGGREGATE  AMOUNT  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON
      8,170,843

12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES    / /

13  PERCENT  OF  CLASS  REPRESENTED  BY  AMOUNT  IN  ROW  (11)
      9.82%

14  TYPE  OF  REPORTING  PERSON
      OO



                                  SCHEDULE 13D

CUSIP No. 874054109

1   NAME  OF  REPORTING  PERSON
      Icahn  Enterprises  Holdings  L.P.

2   CHECK  THE  APPROPRIATE  BOX  IF  A  MEMBER  OF  A  GROUP
      (a) / /
      (b) / /

3   SEC  USE  ONLY

4   SOURCE  OF  FUNDS
      WC

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
    2(d)  or  2(e)                                                           / /

6   CITIZENSHIP  OR  PLACE  OF  ORGANIZATION
      Delaware

NUMBER  OF  SHARES  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON  WITH:

7   SOLE  VOTING  POWER
      0

8   SHARED  VOTING  POWER
      8,170,843

9   SOLE  DISPOSITIVE  POWER
      0

10  SHARED  DISPOSITIVE  POWER
      8,170,843

11  AGGREGATE  AMOUNT  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON
      8,170,843

12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES    / /

13  PERCENT  OF  CLASS  REPRESENTED  BY  AMOUNT  IN  ROW  (11)
      9.82%

14  TYPE  OF  REPORTING  PERSON
      PN



                                  SCHEDULE 13D

CUSIP No. 874054109

1   NAME  OF  REPORTING  PERSON
      Icahn  Enterprises  G.P.  Inc.

2   CHECK  THE  APPROPRIATE  BOX  IF  A  MEMBER  OF  A  GROUP
      (a) / /
      (b) / /

3   SEC  USE  ONLY

4   SOURCE  OF  FUNDS
      WC

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
    2(d)  or  2(e)                                                           / /

6   CITIZENSHIP  OR  PLACE  OF  ORGANIZATION
      Delaware

NUMBER  OF  SHARES  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON  WITH:

7   SOLE  VOTING  POWER
      0

8   SHARED  VOTING  POWER
      8,170,843

9   SOLE  DISPOSITIVE  POWER
      0

10  SHARED  DISPOSITIVE  POWER
      8,170,843

11  AGGREGATE  AMOUNT  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON
      8,170,843

12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES    / /

13  PERCENT  OF  CLASS  REPRESENTED  BY  AMOUNT  IN  ROW  (11)
      9.82%

14  TYPE  OF  REPORTING  PERSON
      CO



                                  SCHEDULE 13D

CUSIP No. 874054109

1   NAME  OF  REPORTING  PERSON
      Beckton  Corp.

2   CHECK  THE  APPROPRIATE  BOX  IF  A  MEMBER  OF  A  GROUP
      (a) / /
      (b) / /

3   SEC  USE  ONLY

4   SOURCE  OF  FUNDS
      WC

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
    2(d)  or  2(e)                                                           / /

6   CITIZENSHIP  OR  PLACE  OF  ORGANIZATION
      Delaware

NUMBER  OF  SHARES  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON  WITH:

7   SOLE  VOTING  POWER
      0

8   SHARED  VOTING  POWER
      8,170,843

9   SOLE  DISPOSITIVE  POWER
      0

10  SHARED  DISPOSITIVE  POWER
      8,170,843

11  AGGREGATE  AMOUNT  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON
      8,170,843

12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES    / /

13  PERCENT  OF  CLASS  REPRESENTED  BY  AMOUNT  IN  ROW  (11)
      9.82%

14  TYPE  OF  REPORTING  PERSON
      CO



                                  SCHEDULE 13D

CUSIP No. 874054109

1   NAME  OF  REPORTING  PERSON
      Carl  C.  Icahn

2   CHECK  THE  APPROPRIATE  BOX  IF  A  MEMBER  OF  A  GROUP
      (a) / /
      (b) / /

3   SEC  USE  ONLY

4   SOURCE  OF  FUNDS

5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO ITEMS
    2(d)  or  2(e)                                                           / /

6   CITIZENSHIP  OR  PLACE  OF  ORGANIZATION
      United  States  of  America

NUMBER  OF  SHARES  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON  WITH:

7   SOLE  VOTING  POWER
      0

8   SHARED  VOTING  POWER
      10,213,552

9   SOLE  DISPOSITIVE  POWER
      0

10  SHARED  DISPOSITIVE  POWER
      10,213,552

11  AGGREGATE  AMOUNT  BENEFICIALLY  OWNED  BY  EACH  REPORTING  PERSON
      10,213,552

12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES    / /

13  PERCENT  OF  CLASS  REPRESENTED  BY  AMOUNT  IN  ROW  (11)
      12.28%

14  TYPE  OF  REPORTING  PERSON
      IN



                                  SCHEDULE 13D

Item 1. Security and Issuer

     The  Schedule  13D  filed  with  the  Securities and Exchange Commission on
December  17,  2009,  as  amended, by the Reporting Persons (the "Schedule 13D")
with  respect  to  the  shares  of  Common Stock, par value $0.01 (the "Shares")
issued  by  Take-Two Interactive Software, Inc. (the "Issuer") is hereby amended
to  furnish  the  additional information set forth herein. All capitalized terms
contained  herein  but not otherwise defined shall have the meanings ascribed to
such  terms  in  the  Schedule  13D.

Item 3. Source and Amount of Funds or Other Consideration

     Item  3  of  the  Schedule  13D  is  hereby  amended by replacing it in its
entirety  with  the  following:

     The  Reporting  Persons  hold,  in  the  aggregate,  10,213,552 Shares. The
aggregate  purchase  price  of  the  Shares  purchased  by the Reporting Persons
collectively  was  $84.5  million  (including  commissions  and premiums for the
options  to  purchase  Shares).  The source of funding for the purchase of these
Shares  was the general working capital of the respective purchasers. The Shares
are  held  by  the  Reporting  Persons  in  margin  accounts together with other
securities. Such margin accounts may from time to time have debit balances. Part
of  the  purchase  price  of  the  Shares purchased by the Reporting Persons was
obtained through margin borrowing. The Shares purchased by the Reporting Persons
are  maintained  in  margin  accounts  that  include  positions in securities in
addition  to  Shares.  As  of  the  close  of  business on January 27, 2010, the
indebtedness  of  (i)  High  River's  margin  account  was  approximately $369.3
million,  (ii)  Icahn  Partners'  margin account was approximately $2.3 million,
(iii)  Icahn Master's margin account was approximately $61.2 million, (iv) Icahn
Master  II's  margin account was zero, and (v) Icahn Master III's margin account
was  zero.

Item 5. Interest in Securities of the Issuer

     Item  5  of  the  Schedule  13D  is  hereby  amended by replacing it in its
entirety  with  the  following:

     (a)  The  Reporting  Persons  may  be  deemed  to  beneficially own, in the
aggregate,  10,213,552 Shares, representing approximately 12.28% of the Issuer's
outstanding Shares (based upon the 83,187,187 Shares stated to be outstanding as
of  December  15,  2009  by  the Issuer in the Issuer's Form 10-K filed with the
Securities  and  Exchange  Commission  on  December  18,  2009).

     (b) High River has sole voting power and sole dispositive power with regard
to  2,042,709  Shares.  Each of Hopper, Barberry and Mr. Icahn has shared voting
power  and shared dispositive power with regard to such Shares. Icahn Master has
sole  voting  power  and sole dispositive power with regard to 3,336,248 Shares.
Each  of  Icahn  Offshore, Icahn Capital, IPH, Icahn Enterprises Holdings, Icahn
Enterprises  GP,  Beckton  and  Mr.  Icahn  has  shared  voting power and shared
dispositive  power  with  regard to such Shares. Icahn Master II has sole voting
power  and sole dispositive power with regard to 1,353,896 Shares. Each of Icahn
Offshore,  Icahn Capital, IPH, Icahn Enterprises Holdings, Icahn Enterprises GP,
Beckton  and Mr. Icahn has shared voting power and shared dispositive power with
regard  to  such  Shares.  Icahn  Master  III  has  sole  voting  power and sole
dispositive  power  with regard to 512,118 Shares. Each of Icahn Offshore, Icahn
Capital,  IPH, Icahn Enterprises Holdings, Icahn Enterprises GP, Beckton and Mr.
Icahn  has  shared voting power and shared dispositive power with regard to such
Shares.  Icahn  Partners  has  sole voting power and sole dispositive power with
regard  to  2,968,581  Shares.  Each of Icahn Onshore, Icahn Capital, IPH, Icahn
Enterprises  Holdings,  Icahn  Enterprises  GP, Beckton and Mr. Icahn has shared
voting  power  and  shared  dispositive  power  with  regard  to  such  Shares.

     Each of Hopper, Barberry and Mr. Icahn, by virtue of their relationships to
High  River  (as  disclosed in Item 2), may be deemed to indirectly beneficially
own  (as that term is defined in Rule 13d-3 under the Act) the Shares which High
River  directly  beneficially  owns.  Each  of  Hopper,  Barberry  and Mr. Icahn
disclaims  beneficial  ownership  of such Shares for all other purposes. Each of
Icahn  Offshore,  Icahn  Capital,  IPH,  Icahn  Enterprises  Holdings,  Icahn
Enterprises  GP, Beckton and Mr. Icahn, by virtue of their relationships to each
of  Icahn Master, Icahn Master II and Icahn Master III (as disclosed in Item 2),
may  be  deemed  to indirectly beneficially own (as that term is defined in Rule
13d-3  under the Act) the Shares which each of Icahn Master, Icahn Master II and
Icahn  Master  III  directly  beneficially  owns.  Each of Icahn Offshore, Icahn
Capital,  IPH, Icahn Enterprises Holdings, Icahn Enterprises GP, Beckton and Mr.
Icahn disclaims beneficial ownership of such Shares for all other purposes. Each
of  Icahn  Onshore,  Icahn  Capital,  IPH,  Icahn  Enterprises  Holdings,  Icahn
Enterprises GP, Beckton and Mr. Icahn, by virtue of their relationships to Icahn
Partners  (as disclosed in Item 2), may be deemed to indirectly beneficially own
(as  that  term  is  defined in Rule 13d-3 under the Act) the Shares which Icahn
Partners  directly beneficially owns. Each of Icahn Onshore, Icahn Capital, IPH,
Icahn  Enterprises  Holdings,  Icahn  Enterprises  GP,  Beckton  and  Mr.  Icahn
disclaims  beneficial  ownership  of  such  Shares  for  all  other  purposes.

     (c)  The following table sets forth all transactions with respect to Shares
effected  during  the  past  sixty  (60)  days  by any of the Reporting Persons,
inclusive of any transactions effected through 5:00 p.m., New York City time, on
January  28,  2010.  Except as otherwise noted below, all such transactions were
purchases  of  Shares  effected  in  the  open  market,  and  the table includes
commissions  paid  in  per  share  prices.

Name of                                                       Purchase Price Per
Reporting           Date  of            No. of Shares         Share (U.S.$)/
Person              Transaction         Purchased             Exercise Price
---------           -----------         -------------         ------------------
High River           12/7/2009           280,000                     7.98
High River           12/8/2009           347,660                     7.92
High River           12/9/2009           166,040                     7.84
High River          12/10/2009           170,000                     7.81
High River          12/11/2009            80,000                     7.79
High River          12/14/2009            22,964                     7.84
High River          12/15/2009               320                     7.86
High River          12/16/2009            31,154                     7.96
High River          12/17/2009           75,0000                     8.18
High River          12/17/2009           156,696 (1)                 5.25 (2)
High River           1/26/2010            99,012                     9.21
High River           1/27/2010            31,002                     9.24
High River           1/27/2010            20,000                     9.21
High River           1/28/2010            36,000                     9.21
High River           1/28/2010            25,000                     9.21

Icahn Partners       12/7/2009           424,410                     7.98
Icahn Partners       12/8/2009           500,474                     7.92
Icahn Partners       12/9/2009           239,021                     7.84
Icahn Partners      12/10/2009           244,724                     7.81
Icahn Partners      12/11/2009           115,164                     7.79
Icahn Partners      12/14/2009            33,058                     7.84
Icahn Partners      12/15/2009               462                     7.86
Icahn Partners      12/16/2009            44,849                     7.96
Icahn Partners      12/17/2009           107,965                     8.18
Icahn Partners      12/17/2009           225,571 (1)                 5.25 (2)
Icahn Partners       1/26/2010           168,998                     9.21
Icahn Partners       1/27/2010            45,054                     9.24
Icahn Partners       1/27/2010            29,064                     9.21
Icahn Partners       1/28/2010            52,318                     9.21
Ichan Partners       1/28/2010            36,332                     9.21

Icahn Master         12/7/2009           469,032                     7.98
Icahn Master         12/8/2009           595,113                     7.92
Icahn Master         12/9/2009           284,222                     7.84
Icahn Master        12/10/2009           291,000                     7.81
Icahn Master        12/11/2009           136,941                     7.79
Icahn Master        12/14/2009            39,310                     7.84
Icahn Master        12/15/2009               547                     7.86
Icahn Master        12/16/2009            53,329                     7.96
Icahn Master        12/17/2009           128,383                     8.18
Icahn Master        12/17/2009           268,226 (1)                 5.25 (2)
Icahn Master         1/26/2010            17,885                     9.21
Icahn Master         1/27/2010            50,636                     9.24
Icahn Master         1/27/2010            32,666                     9.21
Icahn Master         1/28/2010            58,797                     9.21
Icahn Master         1/28/2010            40,830                     9.21

Icahn Master II      12/7/2009           165,713                     7.98
Icahn Master II      12/8/2009           213,909                     7.92
Icahn Master II      12/9/2009           102,163                     7.84
Icahn Master II     12/10/2009           104,599                     7.81
Icahn Master II     12/11/2009            49,222                     7.79
Icahn Master II     12/14/2009            14,130                     7.84
Icahn Master II     12/15/2009               197                     7.86
Icahn Master II     12/16/2009            19,169                     7.96
Icahn Master II     12/17/2009            46,146                     8.18
Icahn Master II     12/17/2009            96,413 (1)                 5.25 (2)
Icahn Master II      1/26/2010           152,645                     9.21
Icahn Master II      1/27/2010            20,548                     9.24
Icahn Master II      1/27/2010            13,256                     9.21
Icahn Master II      1/28/2010            23,860                     9.21
Icahn Master II      1/28/2010            16,570                     9.21

Icahn Master III     12/7/2009            60,845                     7.98
Icahn Master III     12/8/2009            81,144                     7.92
Icahn Master III     12/9/2009            38,754                     7.84
Icahn Master III    12/10/2009            39,677                     7.81
Icahn Master III    12/11/2009            18,673                     7.79
Icahn Master III    12/14/2009             5,360                     7.84
Icahn Master III    12/15/2009                74                     7.86
Icahn Master III    12/16/2009             7,271                     7.96
Icahn Master III    12/17/2009            17,506                     8.18
Icahn Master III    12/17/2009            36,573                     5.25 (2)
Icahn Master III     1/26/2010            56,521                     9.21
Icahn Master III     1/27/2010             7,772                     9.24
Icahn Master III     1/27/2010             5,014                     9.21
Icahn Master III     1/28/2010             9,025                     9.21
Icahn Master III     1/28/2010             6,268                     9.21
_________________________
(1)  Shares  underlying  American-style call options purchased by the applicable
     Reporting  Person, which expire on December 16, 2011. All such call options
     were  exercised  by  the  applicable  Reporting Person on January 21, 2010.
(2)  Per share  exercise  price  of  call  options  purchased  by  the Reporting
     Persons.  Exercise  price  will be adjusted to account for any dividends or
     other  distributions  declared  by  the  Issuer  prior  to  exercise of the
     options.  The  premium  for  such call options was approximately 35% of the
     market  price.




                                   SIGNATURE

     After  reasonable  inquiry  and  to  the  best  of  each of the undersigned
knowledge and belief, each of the undersigned certifies that the information set
forth  in  this  statement  is  true,  complete  and  correct.

Dated:  January  28,  2010

ICAHN  PARTNERS  MASTER  FUND  LP
ICAHN  PARTNERS  MASTER  FUND  II  LP
ICAHN  PARTNERS  MASTER  FUND  III  LP
ICAHN  OFFSHORE  LP
ICAHN  PARTNERS  LP
ICAHN  ONSHORE  LP
BECKTON  CORP.
HOPPER  INVESTMENTS  LLC
BARBERRY  CORP.
HIGH  RIVER  LIMITED  PARTNERSHIP
     By:  Hopper  Investments  LLC,  general  partner

     By:  /s/  Edward  E.  Mattner
          ------------------------
          Name:  Edward  E.  Mattner
          Title:  Authorized  Signatory


ICAHN  CAPITAL  LP
     By:  IPH  GP  LLC,  its  general  partner
     By:  Icahn  Enterprises  Holdings  L.P.,  its  sole  member
     By:  Icahn  Enterprises  G.P.  Inc.,  its  general  partner
IPH  GP  LLC
     By:  Icahn  Enterprises  Holdings  L.P.,  its  sole  member
     By:  Icahn  Enterprises  G.P.  Inc.,  its  general  partner
ICAHN  ENTERPRISES  HOLDINGS  L.P.
     By:  Icahn  Enterprises  G.P.  Inc.,  its  general  partner
ICAHN  ENTERPRISES  G.P.  INC.


     By:  /s/Dominick  Ragone
          -------------------
          Name:  Dominick  Ragone
          Title:  Chief  Financial  Officer





/s/  Carl  C.  Icahn
--------------------
CARL  C.  ICAHN






               [Signature Page of Schedule 13D Amendment No. 2 -
                      Take-Two Interactive Software, Inc.]