UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                  SCHEDULE 13D


                    Under the Securities Exchange Act of 1934

                               Pharmanetics, Inc.
                        --------------------------------
                                (Name of Issuer)

                                  Common Stock
                                  ------------
                         (Title of Class of Securities)

                                    71713J107
                                 (CUSIP Number)

                            Gregory Maloblocki, Esq.
                               Bayer Corporation
                                63 North Street
                                 Medfield, MA
                                  02052-1688

                                with a copy to:
                             Marilyn Mooney, Esq.
                           Fulbright & Jaworski L.L.P.
                           801 Pennsylvania Avenue, NW
                           Washington, D.C.  20004-2615
             ------------------------------------------------------
                  (Name, Address and Telephone Number of Person
               Authorized to Receive Notices and Communications)

                                 April 23, 2001
             -------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule because of ss.ss. 240.13d-1(e),  240.13d-1(f),  or 240.13d-1(g),  check
the following box. [ ]

Note:  Schedules  filed in paper format shall include a signed original and five
copies of this  Schedule,  including all exhibits.  See Rule 240.13d-7 for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).



CUSIP No.  71713J107                                        Page 2 of 9 Pages

1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
           Bayer Corporation

2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
           (a) | |
           (b) [ ]

3          SEC USE ONLY


4          SOURCE OF FUNDS
           WC.

5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
           ITEMS 2(d) OR 2(e)
           [ ]

6          CITIZENSHIP OR PLACE OF ORGANIZATION
           Indiana

                            7        SOLE VOTING POWER
                                     0
        NUMBER OF
          SHARES            8        SHARED VOTING POWER
       BENEFICIALLY                  2,050,000
         OWNED BY
           EACH             9        SOLE DISPOSITIVE POWER
        REPORTING                    0
          PERSON
           WITH             10       SHARED DISPOSITIVE POWER
                                     2,050,000

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2,050,000

12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES SHARES
           [ ]

13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
           22.0%

14         TYPE OF REPORTING PERSON
           CO



CUSIP No.  71713J107                                       Page 3 of 9 Pages

1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
           Bayer Aktiengesellshaft

2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
           (a) | |
           (b) [ ]

3          SEC USE ONLY


4          SOURCE OF FUNDS
           NA

5          CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
           ITEMS 2(d) OR 2(e)
           [ ]

6          CITIZENSHIP OR PLACE OF ORGANIZATION
           Federal Republic of Germany

                            7        SOLE VOTING POWER
                                     0
        NUMBER OF
          SHARES            8        SHARED VOTING POWER
       BENEFICIALLY                  2,050,000
         OWNED BY
           EACH             9        SOLE DISPOSITIVE POWER
        REPORTING                    0
          PERSON
           WITH             10       SHARED DISPOSITIVE POWER
                                     2,050,000

11         AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
           2,050,000

12         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES SHARES
           [ ]

13         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)
           22.0%

14         TYPE OF REPORTING PERSON
           CO




CUSIP No.  71713J107                                          Page 4 of 9 Pages

Item 1.  Security and Issuer.

     This  Statement  relates to shares of common stock,  no par value per share
(the "Common Stock"), of Pharmanetics,  Inc., a North Carolina  corporation (the
"Issuer"), which has its principal executive offices at 9401 Globe Center Drive,
Suite 140, Morrisville,  NC 27560. The Issuer is the successor to Cardiovascular
Diagnostics Inc. ("Cardiovascular") by a merger on December 2, 1998 done for the
purpose of creating a holding  company  structure.  As a result,  Cardiovascular
became a wholly owned subsidiary of the Issuer through a one-to-one  exchange of
shares of common stock.

Item 2.  Identity and Background.

     This  Statement is being filed by Bayer  Corporation  (the  "Company"),  an
Indiana  Corporation with its principal  executive  offices located at 100 Bayer
Road,  Pittsburgh,  Pennsylvania  15205-9741.  The Company is the  successor  by
merger on April 1, 1999 to Chiron Diagnostics Corporation ("Chiron"), a Delaware
corporation. The Company had previously purchased all of the outstanding capital
stock of Chiron on November  30,  1998.  On  September  8, 1998,  Chiron filed a
Schedule  13D as to its  beneficial  ownership  of  shares  of  common  stock of
Cardiovascular,  predecessor to Pharmanetics as described in Item 1 above.  This
Schedule  13D is, in effect,  an  amendment to the Schedule 13D filed by Chiron,
but now filed as a Schedule 13D by the Company as Chiron's successor by merger.

     This statement is also being filed by Bayer Aktiengesellshaft  ("Bayer"), a
German  corporation with its principal  offices located in Leverkusen,  Germany.
Bayer is a German  pharmaceutical and chemical company.  The Company is a wholly
owned  subsidiary  of  Bayer.  Information  as to  the  executive  officers  and
directors of the Company is set forth in Exhibit A hereto and  information as to
the executive officers and directors of Bayer is set forth in Exhibit B hereto.

     During the past five  years,  neither  the  Company  or Bayer  nor,  to the
Company's  knowledge,  any of the  persons  listed in Exhibit A nor,  to Bayer's
knowledge,  any of the  persons  listed in  Exhibit B, has been  convicted  in a
criminal  proceeding  (excluding traffic  violations and similar  misdemeanors).
During the past five years,  neither the Company or Bayer nor, to the  Company's
knowledge, any of the persons listed in Exhibit A nor, to Bayer's knowledge, any
of the persons listed in Exhibit B, has been a party to a civil  proceeding of a
judicial or  administrative  body of competent  jurisdiction  and as a result of
such proceeding was or is subject to a judgment, decree or final order enjoining
future violations of, or prohibiting or mandating activities subject to, federal
or state securities laws or finding any violation with respect to such laws.

Item 3.  Source and Amount of Funds or Other Consideration.

     The source of funds used by the  Company to  purchase  the shares of Common
Stock was the working capital of the Company. The Company paid $17,400,000.00 to
acquire 1,450,000 shares of Common Stock (the "Shares").

Item 4.  Purpose of Transaction.

     On May 1, 2001 the Company acquired the Shares pursuant to a
Stock Purchase Agreement dated April 23, 2001 between the Company and the Issuer
(the  "Agreement").  The  Agreement is filed as an Exhibit to this  statement on
Schedule 13D.




CUSIP No.  71713J107                                      Page 5 of 9 Pages


     Also on April 23, 2001,  the Company and the Issuer entered into an amended
distribution  agreement (the "Distribution  Agreement").  Under the Distribution
Agreement,  in the United States the Company retains  exclusive  rights from the
Issuer to sell and market  routine  coagulation  products.  The  Issuer  will be
primarily responsible for sales, marketing, and technical support activities for
Theranostic  products in the United States.  The Company acquired  non-exclusive
rights in the United  States for  Theranostic  products  and in  exchange  for a
service fee will  provide the Issuer with  administrative  services for billing,
collections  and phone support.  The Company retains  exclusive  rights from the
Issuer to sell and market  Theranostic  products outside the United States.  The
Issuer has filed a copy of the Distribution Agreement with the SEC as an exhibit
to its Current Report on Form 8-k filed April 27, 2001.

     The Company  acquired the Shares for  investment  purposes.  The  Company's
right to sell the  Shares and to acquire  additional  shares of Common  Stock is
limited  by the  Agreement  (see Item 6 below).  Subject to the  Agreement,  the
Company and Bayer intend to review the  investment in the Issuer on a continuing
basis and,  depending  on various  factors,  including  the  Issuer's  business,
affairs and financial  position,  other developments  concerning the Issuer, the
price  level of the Common  Stock,  conditions  in the  securities  markets  and
general  economic  and  industry   conditions,   as  well  as  other  investment
opportunities  available  to the Company and Bayer,  may in the future take such
actions with respect to their  investment in the Issuer as they deem appropriate
in light of the  circumstances  existing  from time to time.  Such  actions  may
include the purchase of additional shares of Common Stock in the open market, in
privately negotiated  transactions or otherwise,  or the sale at any time of all
or a portion of the Shares or other shares of Common Stock hereafter acquired by
the Company and Bayer to one or more purchasers.

     Pursuant to and subject to the limitations  described therein,  the Company
has the right to nominate  one  representative  to the board of directors of the
Issuer.  The number of nominees may be increased to two nominees in the event of
an  increase  in the size of the  Issuer's  Board of  Directors  to nine or more
members and may be reduced to none based on the Company's equity ownership level
in the  Issuer.  The  Issuer has agreed  that under no  circumstances  shall any
holder  of  the  Issuer's   capital  stock  (other  than  an  individual)   that
beneficially  owns  fewer  shares of the  Issuer's  voting  securities  than the
Company  be  entitled  to  nominate,   nor  shall  the  Issuer  nominate,   more
representatives  of such  holder to the Board of  Directors  than the Company is
entitled to nominate.

     The Issuer has agreed that it will not,  prior to January 1, 2003,  make or
recommend  to its  shareholders  any  amendment  to  the  Issuer's  Articles  of
Incorporation  or Bylaws which would impose  limitations  on the legal rights of
the  Company  as a  shareholder  (other  than  those  imposed  pursuant  to this
Agreement)  based  upon  the  size of  security  holding  permitted  under  this
Agreement,  the  business  in  which a  security  holder  is  engaged  or  other
considerations applicable to the Company and not to security holders generally.

     Except as  described  above,  neither the Company nor Bayer has any current
plans or proposals that relate to or would result in any of the events set forth
in paragraphs  (a) through (j) of Item 4. The Company and Bayer may, at any time
and from time to time,  review or reconsider  their position and/or change their
purpose and/or formulate plans or proposals with respect thereto.



CUSIP No.  71713J107                                     Page 6 of 9 Pages

Item 5.  Interest in Securities of the Issuer.

     (a) The Company  beneficially owns 2,050,000 shares of Common Stock. As the
Company is a wholly owned subsidiary of Bayer,  Bayer also beneficially owns the
same 2,050,000 shares of Common Stock. This number of shares represents 22.0% of
the outstanding shares as calculated under Rule 13d-3 of the Securities Exchange
Act of 1934, as amended,  or 19.9% of the  outstanding  voting shares as defined
under the North Carolina  Shareholder  Protection  Act. To the best knowledge of
each of the Company and Bayer,  no director or  executive  officer of either the
Company or Bayer beneficially owns any shares of Common Stock.

     (b) As the Company is a wholly owned  subsidiary of Bayer,  the Company and
Bayer share voting and investment power over the 2,050,000 shares.

     (c) Other than the  transactions  contemplated  by the Agreement  described
herein,  neither the Company or Bayer nor, to the best  knowledge of the Company
or Bayer,  any  director  or  executive  officer of the  Company  or Bayer,  has
effected any transactions in the Common Stock during the past 60 days.

     (d) No person,  other than the Company,  has the right to receive dividends
from the  Common  Stock and no person  other than the  Company  has the right to
receive the proceeds from the sale of the Common Stock.


Item 6.  Contracts, Arrangements, Understandings or Relationships with Respect
to the Issuer.

     The Agreement  requires the Company not to exceed 20% beneficial  ownership
without the Issuer's consent,  except in certain circumstances.  The Company has
certain  preemptive  rights  pursuant to the  Agreement as more fully  described
therein.  If the Issuer proposes the issuance of certain new  securities,  then,
except in certain circumstances more fully described in the Agreement,  prior to
each such issuance of such new securities, the Issuer shall offer to the Company
a pro rata share of such new  securities.  The Agreement thus allows the Company
to acquire  additional  shares of Common  Stock in order to maintain  its equity
ownership  level.  In  the  event  the  Issuer   repurchases  shares  of  voting
securities,  including  any  redemption  of its Series A  Convertible  Preferred
Stock, the Issuer shall offer to purchase such number of shares from the Company
on a pro rata basis as  necessary to ensure that its  ownership  does not exceed
20% of the Issuer's voting shares.



CUSIP No.  71713J107                                    Page 7 of 9 Pages

     Prior to the first  anniversary of the purchase of the Shares,  the Company
may not sell,  transfer  or  otherwise  dispose of any Shares  except in certain
circumstances more fully described in the Agreement. The Agreement also contains
certain  restrictions  on the  transfer of Common  Stock held by the Company and
grants  the  Issuer  a right of first  refusal  with  respect  to  certain  such
transfers.  The Issuer has agreed to provide  the Company  certain  registration
rights for the Shares.  The  Company has the right to two demand  registrations.
The Issuer may postpone a demand registration under the circumstances  specified
in the Agreement.

     As more fully  specified in the  Agreement,  the Company has Agreed that it
will not deposit the Issuer's  voting  securities into a voting trust or (except
as  provided  in the  Agreement)  make any similar  arrangements  regarding  the
Issuer's  voting  securities,  engage in a proxy  contest  or  solicitation,  or
participate in a group with other holders of the Issuer's voting securities.

     The Agreement  grants the Company  certain rights to nominate  directors to
the Issuer's  Board of  Directors as set forth in Item 4 above.  The Company has
agreed  to vote its  shares of Common  Stock  for the  election  of the slate of
nominees  proposed by the Issuer's  Board for election to its Board of Directors
(so long as the Company's nominees are included in such slate and the Issuer has
otherwise  complied  with  its  covenants  regarding  Board  membership)  and in
accordance  with  the  direction  of  the  Board  on any  non-Company  sponsored
shareholder  proposal.  The Company is  otherwise  free to vote its shares as it
elects.

     Upon the  occurrence  of certain  events  involving  a  possible  Change in
Control  Transaction (as defined in the Agreement)  certain of the  restrictions
and rights set forth above and in the Agreement  are modified or terminated  and
certain  additional  rights may come into  effect.  If the price per share to be
paid to  shareholders of the Issuer in connection with certain Change in Control
Transactions (the "Change in Control Price Per Share") is less than the purchase
price per share as to the  Shares or $10.00 per share as to the  600,000  shares
previously  acquired (the  "Original  Shares") and the Company is not in default
under the Distribution  Agreement  through the date of the Change in Control (as
defined  in the  Agreement),  then  the  Issuer  shall be  obligated  to pay the
Company  (a) for each of the Shares the Company then holds,  an amount equal to
the purchase  price per share minus the Change in Control  Price Per Share,  and
(b) for each of the Original  Shares the Company then holds,  an amount equal to
$10.00 per  Original  Share  minus the Change in Control  Price Per Share,  such
amounts to be paid to the Company in addition to the Change in Control Price Per
Share to be  received  in  connection  with the Change in  Control  Transaction;
provided  that the covenant  shall  terminate as to any proposal for a Change in
Control  Transaction  initiated after December 31, 2002,  except with respect to
closing  of a  proposal  or Change in  Control  Transaction  initiated  prior to
December 31, 2002.

     The  Agreement  amends the covenants  (except the one year holding  period)
contained  in  that  certain  Stock  Purchase   Agreement   between  Chiron  and
Cardiovascular  dated August 28, 1998 pursuant to which Chiron purchased 600,000
shares of common stock in  Cardiovascular  that were  thereafter  exchanged on a
one-for-one basis for shares of Common Stock of the Issuer.

     The  description of the Agreement is qualified in its entirety by reference
to such  agreement,  a copy of which is filed as an exhibit to this statement on
Schedule 13D.




CUSIP No.  71713J107                                      Page 8 of 9 Pages


Item 7.  Material to be Filed as Exhibits.


               Exhibit A    Information  concerning  the  Company's  executive
                            officers and directors.
               Exhibit B    Information  concerning Bayer's executive officers
                            and directors.
               Exhibit C    Common Stock Purchase Agreement made as of
                            April 23, 2001 between Pharmanetics, Inc.
                            and Bayer Corporation




CUSIP No.  71713J107                                     Page 9 of 9 Pages



                                    Signature

    After  reasonable  inquiry and to the best of my  knowledge  and  belief,  I
certify that the  information  set forth in this  amendment to this statement is
true and correct.

Date:  May 3, 2001                     BAYER CORPORATION


                                    By:  /s/ Rolf A. Classon
                                         ------------------------
                                         Rolf A. Classon
                                         Executive Vice President

                                         BAYER AKTIENGESELLSHAFT


                                    By:  /s/ Dr. Roland Hartwig
                                         ------------------------
                                         Dr. Roland Hartwig
                                         General Counsel




                                                                       Exhibit A


                DIRECTORS AND EXECUTIVE OFFICERS OF BAYER CORPORATION

     The name, business address,  and present principal occupation or employment
of each of the  directors and executive  officers of Bayer  Corporation  are set
forth below.  Unless  otherwise  indicated,  the  business  address of each such
director and executive officer is Bayer Corporation, 100 Bayer Road, Pittsburgh,
PA  15205-9741.  All the  directors  and  executive  officers  listed  below are
citizens of the United States,  except for Dr. Attila Molnar, Dr.  Frank-Joachim
Morich, Werner Wenning, Gunter Hilken, H.H. Wehmeier, Dr. Wolfgang Plischke, Dr.
Frank Wenzel, and Heinz Heumueller,  who are citizens of the Federal Republic of
Germany, Emil Lansu, who is a citizen of The Netherlands,  and Rolf Classon, who
is a citizen of Sweden.



NAME AND BUSINESS ADDRESS                   PRESENT PRINCIPAL OCCUPATION OR EMPLOYMENT
- -------------------------                   -------------------------------------------
                                        
Dr. Attila Molnar.........................  Chairman, Board of Directors;
  Bayer AG;                                 Member, Board of Management, Bayer AG.
  51368 Leverkusen, Germany
Dr. Frank-Joachim Morich                    Member, Board of Directors;
  Bayer AG                                  Member, Board of Management, Bayer AG.
  51368 Leverkusen, Germany
Werner Wenning                              Member, Board of Directors;
  Bayer AG                                  Member, Board of Management, Bayer AG.
  51368 Leverkusen, Germany
H.H. Wehmeier.............................  Member, Board of Directors; President and
                                            Chief Executive Officer, Bayer Corporation.
Joseph A. Akers...........................  Executive Vice President, Chief
                                            Administrative Officer, Bayer Corporation.
                                            Chief Financial Officer, Bayer Corporation.
Gary Balkema..............................  President, Consumer Care Business Group,
  Bayer Corporation                         Bayer Corporation.
  36 Columbia Road
  P.O. Box 1910
  Morristown, NJ 07962
Nicholas T. Cullen, Jr. ..................  Executive Vice President and President,
                                            Plastics Division, Bayer Corporation.
R.D. Fuchs................................  Executive Vice President and Chief Technology
                                            Officer, Bayer Corporation.
Gunter Hilken.............................  Executive Vice President and President,
  Bayer Corporation                         Fibers, Additives & Rubber Division, Bayer
  2603 West Market Street                   Corporation.
  Akron, OH  44313
Emil Lansu................................  Executive Vice President and
  Bayer Corporation                         President, Agriculture Division,
  8400 Hawthorn Road                        Bayer Corporation.
  Kansas City, MO 64120





                                      A-1





NAME AND BUSINESS ADDRESS                   PRESENT PRINCIPAL OCCUPATION OR EMPLOYMENT
- -------------------------                 -------------------------------------------
                                         

Leslie F. Nute............................  Senior Vice President, General Counsel and
                                            Secretary, Bayer Corporation.
Howard W. Reed............................  Senior Vice President, Human Resources, Bayer
                                            Corporation.
Dr. Frank Wenzel..........................  Senior Vice President and Controller, Bayer
                                            Corporation.
Dr. John L. Williams......................  Executive Vice President, Bayer Corporation,
                                            President, Coatings and Colorants Division,
                                            Bayer Corporation.
Margo Barnes..............................  Senior Vice President, Corporate
                                            Communications, Bayer Corporation.
Dr. Wolfgang Plischke.....................  Executive Vice President and President
  400 Morgan Lane                           Pharmaceutical Division, Bayer Corporation.
  West Haven, CT 06516
Lawrence D. Stern.........................  Executive Vice President, Bayer Corporation.
Jon R. Wyne...............................  Senior Vice President and Treasurer, Bayer
                                            Corporation.
Rolf Classon..............................  Executive Vice President and
  Bayer Corporation                         President -- Diagnostics, Bayer Corporation.
  511 Benedict Avenue
  Tarrytown, NY 10591
Paul F. Wright                              Vice President - Tax Department,
                                            Bayer Corporation
Heinz Heumueller                            Executive Vice President, Bayer Corporation.








                                      A-2





                                                                       Exhibit B

                      DIRECTORS AND EXECUTIVE OFFICERS OF
                                   BAYER AG


     The name, business address,  and present principal occupation or employment
of each of the directors and executive officers of Bayer AG are set forth below.
Unless  otherwise  indicated,  the  business  address of each such  director  or
executive  officer  is Bayer  Aktiengesellschaft,  D-51368  Leverkusen,  Federal
Republic of Germany.  All the directors and executive  officers listed below are
citizens of the Federal Republic of Germany,  except for Dr. Pol Bamelis and Dr.
Andre Leysen,  who are citizens of Belgium,  and Loedewijk van Wachem,  who is a
citizen of The Netherlands.


NAME AND BUSINESS ADDRESS                   PRESENT PRINCIPAL OCCUPATION OR EMPLOYMENT
- -------------------------                 -------------------------------------------
                                        
Dr. Manfred Schneider.....................  Chairman, Board of Management.
Dr. Pol Bamelis...........................  Member, Board of Management.
Dr. Attila Molnar.........................  Member, Board of Management; Member, Board of
                                            Directors, Bayer Corporation.
Dr. Frank-Joachim Morich..................  Member, Board of Management; Member, Board of
                                            Directors, Bayer Corporation.
Dr. Udo Oels..............................  Member, Board of Management.
Werner Spinner............................  Member, Board of Management.
Werner Wenning............................  Member, Board of Management; Member, Board of
                                            Directors, Bayer Corporation.
Dr. Gottfried O. Zaby.....................  Member, Board of Management.
Hermann Josef Strenger....................  Chairman, Supervisory Board.
Erhard Gipperich..........................  Vice Chairman, Supervisory Board;
                                            Chairman, Works Council.
Petra Brayer..............................  Member, Supervisory Board; Vice-Chairman,
  Bayer Faser GmbH                          Works Council, Bayer Faser GmbH.
  41538 Dormagen, Germany
Karl Josef Ellrich........................  Member, Supervisory Board; Chairman, Works
                                            Council, Dormagen plant, Bayer AG.
Detlef Fahlbusch..........................  Member, Supervisory Board; Regional President
  IG BCE Nordrhein                          Northrhein of Mining, Chemical and Energy
  40476 Dusseldorf, Germany                 Industrial Trade Union of Germany.
Dr. Martin Kohlhaussen....................  Member, Supervisory Board; Chairman of
  Commerzbank Aktiengesellschaft            the Board of Managing Directors of
  60261 Frankfurt am Main, Germany          Commerzbank AG.
Hilmar Kopper.............................  Member, Supervisory Board; Chairman,
  Deutsche Bank AG                          Supervisory Board, Deutsche Bank AG.
  60325 Frankfurt, Germany
Petra Kronen..............................  Member, Supervisory Board;
  Rheinuferstrasse 7-9                      Chairman, Works Council, Uerdingen
  47829 Krefeld, Germany                    plant, Bayer AG.
Dr. Manfred Lennings......................  Member, Supervisory Board; Industrial
  Schmachtenbergstrasse 142                 Consultant.
  45219 Essen, Germany




                                      B-1




NAME AND BUSINESS ADDRESS                    PRESENT PRINCIPAL OCCUPATION OR EMPLOYMENT
- -------------------------                  -------------------------------------------
                                        

Dr. h.c. Andre Leysen.....................  Member, Supervisory Board; Chairman, Board of
  Agfa-Gevaert N.V.                         Directors, Agfa-Gevaert N.V.
  Septestraat 27
  B-2640 Mortsel, Belgium
Dr. h.c. Helmut Maucher...................  Member, Supervisory Board.
  Nestle-Haus
  60528 Frankfurt, Germany
Rolf Nietzard.............................  Member, Supervisory Board; Member of Works
                                            Council, Leverkusen Plant, Bayer AG.
Dr. Heinrich Pierer von Esch..............  Member, Supervisory Board; Chairman of the
  Siemens AG                                Managing Board, President and Chief Executive
  80333 Munchen, Germany                    Officer, Siemens AG.
Waltraud Schlaefke........................  Member, Supervisory Board; Vice-Chairman,
  Wolff Walsrode AG                         Works Council, Wolff Walsrode AG.
  29655 Walsrode, Germany
Hubertus Schmoldt.........................  Member, Supervisory Board; President,
  IG Bergbau, Chemie, Energie               Executive Board, Mining, Chemical and Energy
  Konigsworther Platz 6                     Industrial Trade Union of Germany.
  30167 Hannover, Germany
Dieter Schulte............................  Member, Supervisory Board; President, German
  German Trade Union Federation DGB         Trade Union Federation-DGB.
  10178 Berlin, Germany
Dr. Eugen Velker                            Head of Technical Coordination TDI,
                                            Polyurethanes
Loedewijk van Wachem......................  Member, Supervisory Board; Chairman,
  Carel van Bylandtlaan 30                  Supervisory Board, Royal Dutch
  NL-2596 HR The Hague, Netherlands         Petroleum Company.
Professor Dr. Ernst-Ludwig Winnacker......  Member, Supervisory Board; President, German
  Deutsche Forschungsgemeinschaft           Science Foundation.
  53170 Bonn, Germany
Dr. Hermann Wunderlich....................  Member, Supervisory Board.
  Arndtstrabe 8
  51519 Odenthal, Germany



                                      B-2

                                                                       Exhibit C

                         COMMON STOCK PURCHASE AGREEMENT

         This Common Stock Purchase  Agreement (the  "Agreement")  is made as of
April 23, 2001,  between  Pharmanetics,  Inc, a North Carolina  corporation (the
"Company"), and Bayer Corporation, an Indiana corporation (the "Purchaser").

     Section 1. Authorization and Sale of Common Stock

     1.1  Authorization.  The Company has  authorized  the sale and  issuance to
Purchaser of up to one million,  four hundred fifty thousand  (1,450,000) shares
of its Common Stock, no par value per share (the "Common Stock").

     1.2 Sale of Common Stock.  Subject to the terms and conditions  hereof, the
Company will issue and sell to the Purchaser and the Purchaser will buy from the
Company one million,  four hundred fifty thousand  (1,450,000)  shares of Common
Stock (the  "Shares")  at a per share  purchase  price of $12.00 (the  "Purchase
Price Per Share"),  for an aggregate purchase price of seventeen  million,  four
hundred thousand dollars ($17,400,000.00).

     Section 2. Closing Date; Delivery

     2.1  Closing  Date.  The  Closing  of the  purchase  and sale of the Shares
hereunder (the "Closing") shall be held at the offices of Wyrick Robbins Yates &
Ponton LLP, 4101 Lake Boone Trail, Suite 300, Raleigh,  North Carolina, at 12:00
p.m.  on May 1,  2001,  or at such  other  time,  date and place  upon which the
Company  and the  Purchaser  shall  mutually  agree (the date of the  Closing is
hereinafter referred to as the "Closing Date").

     2.2 Delivery.  At the Closing,  the Company will deliver to the Purchaser a
certificate  or  certificates  representing  the Shares  against  payment of the
purchase price therefor by wire transfer of  immediately  available  funds or by
certified  or  cashier's  check drawn on a United  States  bank,  payable to the
Company in the amount of the  applicable  purchase  price.  The  certificate  or
certificates  shall  be  subject  to a legend  restricting  transfer  under  the
Securities  Act of 1933,  as amended (the  "Securities  Act"),  and referring to
restrictions on transfer and rights of first refusal  herein,  such legend to be
substantially as follows:

          The shares  represented  by this  certificate  have been  acquired for
          investment  and have not been  registered  under the Securities Act of
          1933, as amended.  Such shares may not be sold or  transferred  in the
          absence of such registration or an opinion of counsel  satisfactory to
          the Company as to the availability of an exemption from registration.

          The shares represented by this certificate are subject to restrictions
          on transfer,  including any sale, pledge or other  hypothecation,  set
          forth in an  agreement  between the Company and Bayer  Corporation,  a
          copy of which  agreement may be obtained at no cost by written request
          made by the holder of record of this

                                      1


          certificate to the Secretary of the Company at the Company's principal
          executive offices.

     Section 3. Representations and Warranties of the Company

     The Company hereby represents and warrants to the Purchaser as follows:

     3.1 Organization. The Company and each of its Subsidiaries is a corporation
duly  organized  and  validly  existing  under  the  laws of the  State of North
Carolina and is in good  standing  under such laws.  The Company and each of its
Subsidiaries  has  requisite  corporate  power and  authority to own,  lease and
operate its  properties  and assets,  and to carry on its  business as presently
conducted  and  as  proposed  to be  conducted.  The  Company  and  each  of its
Subsidiaries  is  qualified  to do  business  as a foreign  corporation  in each
jurisdiction  in which  the  ownership  of its  property  or the  nature  of its
business requires such  qualification,  except where failure to so qualify would
not have a Material  Adverse Effect.  The Company has furnished to the Purchaser
true and correct copies of the Articles of  Incorporation  and Bylaws as amended
of the Company and each of its Subsidiaries and will furnish upon request to the
Purchaser true and correct copies of any amendments  thereto through the term of
this Agreement.  The Company has two subsidiaries,  Cardiovascular  Diagnostics,
Inc. and Coeur Laboratories, Inc., each of which is wholly-owned by the Company.
References  in  Section  3 to the  Company  shall be deemed  to  include,  where
appropriate,  and to be given  separately  with respect to, the Company and each
Subsidiary.

     3.2 Capitalization. The authorized capital stock of the Company consists of
40,000,000  shares of Common Stock,  no par value per share,  of which 7,869,285
shares were issued and outstanding as of April 23, 2001 and 1,000,000  shares of
preferred  stock, no par value,  of which 120,000 shares  designated as Series A
Convertible  Preferred Stock (the "Preferred Stock") have been issued and 97,500
shares of Preferred  Stock were issued and outstanding as of April 23, 2001. All
such issued and outstanding  shares have been duly authorized and validly issued
and are fully paid and non-assessable.  Upon Closing,  the Company shall have at
least  10,294,285  "voting  shares"  within the  meaning  of the North  Carolina
Shareholder Protection Act. The Company has reserved an additional (a) 1,477,399
shares of its Common Stock for issuance to  employees,  officers,  directors and
consultants  to the  Company  as may be  determined  by the  Company's  Board of
Directors  from  time to time  pursuant  to its  stock  option  plans,  of which
1,311,898  shares were subject to  outstanding  options as of April 23, 2001 (b)
975,000  shares of its Common  Stock for  issuance  to holders of the  Preferred
Stock  upon  conversion  thereof,  and (c)  251,000  shares of Common  Stock for
issuance to holders of the Warrants  upon exercise  thereof.  There are no other
options,  warrants,  conversion privileges or other contractual rights presently
outstanding to purchase or otherwise  acquire any authorized but unissued shares
of the Company's or of any Subsidiary's capital stock or other securities.

     3.3 Authorization. The Company has all corporate right, power and authority
to enter into this  Agreement and to consummate  the  transactions  contemplated
hereby and  thereby.  All  corporate  action on the part of the  Company and its
Board of Directors  necessary  for the  authorization,  execution,  delivery and
performance of this Agreement by the Company, the authorization,  sale, issuance
and delivery of shares of Common Stock contemplated  hereby, and

                                       2

the  performance  of the  Company's  obligations  hereunder  has been taken.  No
approval of the holders of capital  stock of the Company is necessary  under any
laws or under requirements of NASDAQ for the authorization,  execution, delivery
and  performance  of this  Agreement by the Company,  the  authorization,  sale,
issuance  and delivery of shares of Common Stock  contemplated  hereby,  and the
performance of the Company's obligations hereunder. This Agreement has been duly
executed and delivered by the Company and constitutes a legal, valid and binding
obligation of the Company,  enforceable  against the Company in accordance  with
its terms.  Upon the issuance and delivery of the Shares as contemplated by this
Agreement, the Shares will be validly issued, fully paid and nonassessable.  The
issuance  and sale of the Shares  contemplated  hereby will not give rise to any
preemptive  rights or rights of first refusal in existence on the date hereof on
behalf of any person. There are no preemptive rights, rights of first refusal or
other  similar  rights on behalf of any Person under any provision of applicable
law or any provision of the Articles of  Incorporation  or Bylaws of the Company
or of any  agreement or  instrument  to which the Company is a party or by which
the Company is bound in respect of any capital stock or other  securities of the
Company  other  than  pursuant  to  this  Agreement  and  the  Preferred   Stock
anti-dilution  provisions.  The issuance, sale and delivery of the Shares to the
Purchaser will convey to the Purchaser good and marketable title to such shares,
free and clear of all liens.

     3.4 No Conflict. The execution and delivery of this Agreement does not, and
the consummation of the transactions  contemplated hereby will not (a) result in
any violation of, or default (with or without notice of lapse of time, or both),
or give rise to a right of  termination,  cancellation  or  acceleration  of any
material obligation or to a loss of a material benefit,  under, any provision of
the Certificate of  Incorporation  or Bylaws of the Company or any Subsidiary or
any  mortgage,  indenture,  lease or other  agreement  or  instrument,  license,
judgment,  order, decree, statute, law, ordinance, rule or regulation applicable
to the  Company or any  Subsidiary,  or any of their  respective  properties  or
assets;  (b) result in the creation or imposition of any lien upon any assets or
properties  of the Company or any  Subsidiary  except  pursuant  hereto;  or (c)
violate  or  conflict  with any law or Order  applicable  to the  Company or any
Subsidiary or any of their  respective  assets or properties of any Governmental
Entity having  jurisdiction  over the Company or any  Subsidiary or any of their
assets or properties.

     3.5 Accuracy of Reports.

     (a)  SEC Reports.  All reports required to be filed by the Company with the
          Securities  and Exchange  Commission  (the "SEC") under the Securities
          Exchange Act of 1934, as amended (the "Exchange Act"),  have been duly
          filed,  were in substantial  compliance with the requirements of their
          respective  forms,  were complete and correct in all material respects
          as of the dates at which the information was furnished,  and contained
          (as of such dates) no untrue  statement of a material  fact or omitted
          to state a material  fact  necessary  in order to make the  statements
          made  therein,  in light of the  circumstances  under  which they were
          made, not misleading.  Other than the SEC Reports, the Company has not
          filed or been required to file any other  reports or  statements  with
          the SEC since January 1, 1998.

                                      3


     (b)  Financial  Statements.  Each of (i) the  consolidated  balance  sheets
          (including   the  related   notes  and   schedules)   included  in  or
          incorporated  by reference  into the SEC Reports  fairly  presents the
          consolidated financial position of the Company and its Subsidiaries as
          of the date thereof,  subject, in the case of unaudited statements, to
          normal year-end adjustments,  and (ii) the consolidated  statements of
          income (or statements of results of operations),  shareholders' equity
          and cash flows (including the related notes and schedules) included in
          or  incorporated by reference into the SEC Reports fairly presents the
          results of operations,  retained  earnings and cash flows, as the case
          may be, of the Company and its Subsidiaries (on a consolidated  basis)
          for the periods set forth therein  (subject,  in the case of unaudited
          statements,  to normal year-end adjustments and except as permitted by
          Form 10-Q of the SEC) in each case in accordance  with GAAP applied on
          a consistent  basis  throughout the periods  covered (except as stated
          therein or in the notes thereto) and in compliance  with the rules and
          regulations of the SEC.

     (c)  Absence of Certain Changes.  Except for  transactions  contemplated by
          this Agreement or as disclosed in the SEC Reports,  since December 31,
          2000,  there  have  not  been any  changes,  conditions,  occurrences,
          circumstances  or other  events that have had or could  reasonably  be
          expected to have a Material Adverse Effect.

     3.6 Governmental Consents, etc. No consent, approval or authorization of or
designation,  declaration or filing with any Governmental  Entity on the part of
the Company or any  Subsidiary is required in connection  with the execution and
delivery of this Agreement,  the offer,  sale or issuance of the Shares,  or the
consummation of any other transaction  contemplated hereby,  except such filings
as may be  required  to be made  with  the  SEC,  the  National  Association  of
Securities Dealers, Inc. (the "NASD") and the North Carolina Secretary of State.

     3.7  Litigation.  Except as disclosed in SEC Reports,  there are no claims,
suits, actions,  proceedings,  arbitrations or investigations pending or, to the
knowledge of the Company,  threatened  in writing  against the Company or any of
its Subsidiaries;  nor are there any Orders outstanding against or applicable to
the Company or any of its  Subsidiaries or against or applicable to any of their
respective assets, properties or businesses.

     3.8 Intellectual Property.

     (a)  All patents and trademark  applications and  registrations  related to
          the  Intellectual  Property  exist  and have been  maintained  in good
          standing,  including  without  limitation,  the timely  payment of any
          maintenance   fees  and  annuities   thereon.   The  Company  and  its
          Subsidiaries have taken all commercially  reasonable  actions and made
          all  commercially  reasonable  applications  and  filings  pursuant to
          applicable  law to secure,  perfect  and protect  their  rights in the
          Intellectual Property and neither the Company and its Subsidiaries nor
          any of their respective agents, employees,  investors and counsel have
          practiced   inequitable   conduct  under  the  patent

                                      4


          laws or other  applicable  laws with respect to any of the  foregoing.
          The  Company  and  its   Subsidiaries   have  taken  all  commercially
          reasonable steps (including without limitation  entering into employee
          invention,   confidentiality,   non-disclosure   and   non-competition
          agreements with all officers, directors, shareholders and employees of
          the Company and its  Subsidiaries  with access to or  knowledge of the
          Intellectual  Property  used or held  for use in the  business  of the
          Company and its  Subsidiaries  (and the products and technology of the
          Company and its  Subsidiaries))  to safeguard and maintain the secrecy
          and  confidentiality  of,  and  to  assign  to  the  Company  and  its
          Subsidiaries,  all of such  officers,  directors',  shareholders'  and
          employees' as  applicable,  rights in all such  Intellectual  Property
          invented  or  developed  to the  greatest  extent,  and not beyond the
          greatest  extent  permitted by  applicable  law. All  consultants  and
          contractors  to  the  Company  and  its  Subsidiaries  have  signed  a
          confidentiality and invention  assignment agreement for the benefit of
          the  Company  and its  Subsidiaries  to assign  such  consultants'  or
          contractors'  as applicable,  rights in  Intellectual  Property to the
          Company and its  Subsidiaries  and to prohibit  use or  disclosure  of
          trade secrets and confidential information.

     (b)  The Company and its Subsidiaries own or are duly licensed or otherwise
          have  the  right  to use all the  Intellectual  Property  and all such
          Intellectual  Property is valid and enforceable by the Company and its
          Subsidiaries  against third parties.  The Company and its Subsidiaries
          own on an exclusive basis,  free and clear of any  encumbrances,  have
          record title, and have the unrestricted right to use, license, sell or
          dispose of, and the right to bring  infringement  actions with respect
          to all the Intellectual  Property. The Company and its Subsidiaries do
          not pay, and have no obligation  (whether  absolute or  contingent) to
          pay,  royalties,  honoraria,  fees or other  payments to any Person by
          reason of the  ownership,  use,  license,  sale or  disposition of any
          Intellectual  Property  right.  Neither the Company nor any Subsidiary
          has  received  notice  (written  or oral) of any  claim of any  Person
          asserting  rights in, or a conflict with, the  Intellectual  Property.
          Without limiting the foregoing,  no other Person has claimed the right
          to use any Trademark which is identical or confusingly  similar to any
          Trademark  used by the  Company  and  its  Subsidiaries.  Neither  the
          Company nor any  Subsidiary has provided  notice  (written or oral) to
          any Person of  infringement  of any  Intellectual  Property right and,
          there is no reasonable basis for such a claim.

     (C)  Except  for  the BMC  litigation  disclosed  to  Purchaser  and  which
          litigation has been finally settled, (i) no written or unwritten claim
          has been anticipated, evaluated or asserted against the Company or any
          Subsidiary to the effect that the  operation or proposed  operation of
          the business or making, using or selling any product or performance of
          any service  infringes upon or conflicts with the rights of any Person
          with respect to any patents,  patent  application,  Trademarks,  trade
          names,  trade  secrets,

                                       5

          designs,  inventions,  works of authorship or copyrights,  and (ii) no
          claim has been asserted,  suspected or evaluated by the Company or any
          Subsidiary  against any Person that such Person has  infringed  any of
          the Intellectual Property.

     (d)  Each of the parties thereto have performed,  in all material respects,
          all obligations under each Intellectual  Property  Agreement which are
          required to be  performed  by such party,  and there is no default (or
          event which with notice or lapse of time would  constitute  a default)
          thereunder.   Each  Intellectual  Property  Agreement  is  enforceable
          against each of the parties thereto pursuant to its terms.

     (e)  To the  knowledge  of  the  Company,  the  operation  of the  business
          (including without limitation the research and development  operations
          of the Company and its  Subsidiaries  or the  manufacture,  sale, use,
          trade dress, packaging, license, or other exploitation of products and
          technology  currently or proposed to be marketed or in development and
          delivery or  performance  of services) does not and will not infringe,
          trespass or otherwise violate the Intellectual  Property rights of any
          Person.  Without  limiting the foregoing,  neither the Company nor any
          Subsidiary has received a notice  (written or oral) of infringement of
          any Intellectual Property right held by another Person and there is no
          reasonable  basis  for  such a  claim.  Neither  the  Company  nor any
          Subsidiary  is obligated to  indemnify  any Person for any  liability,
          cost or expense  arising from such  Person's use,  sale,  licensing or
          disposition of any Intellectual Property or such Person's manufacture,
          use, sale,  license or other  exploitation of any product,  service or
          technology.

     (f)  No claim or  potential  claim has been  evaluated  or  anticipated  or
          suspected (i) to the effect that any of the  Intellectual  Property is
          invalid or unenforceable or (ii) otherwise related to the Intellectual
          Property, except for the BMC litigation.

     (g)  The Company  and its  Subsidiaries  have  developed  all  Intellectual
          Property used or held for use in the business  through its own efforts
          for its own account and has good and clear title thereto, and there is
          no  contract   obligation,   license,   lien,   encumbrance,   alleged
          infringement,  dispute,  potential  dispute,  claim or other  cloud of
          title   concerning  such   Intellectual   Property   whatsoever.   The
          Intellectual  Property  used or held  for use in the  business  of the
          Company and its Subsidiaries is not being infringed by any third party
          proprietary  interest,  including (without limitation) any third party
          patent,   copyright,   Trademark,   or  trade  secret  interest.   The
          Intellectual  Property used or held for use in the business is, to the
          knowledge  of  the  Company,   fully  eligible  for  protection  under
          applicable  law and has  not  been  forfeited,  abandoned,  lapsed  or
          donated in any way into the public domain. All of the trade secrets of
          the Company and its  Subsidiaries  have been  maintained in confidence
          and are  not  known  to any

                                       6

          third party. All personnel,  including employees,  agents, consultants
          and  contractors,  who  have  contributed  to or  participated  in the
          conception and  development of the  Intellectual  Property  either (i)
          have been a party to a work-for-hire relationship with the Company and
          its  Subsidiaries  that has accorded the Company and its  Subsidiaries
          full,  effective and exclusive  original ownership of all tangible and
          intangible property arising with respect to the Intellectual  Property
          or (ii)  have  executed  instruments  of  assignment  in  favor of the
          Company and its  Subsidiaries  as assignee  that have  conveyed to the
          Company and its Subsidiaries full,  effective and exclusive  ownership
          of all tangible and intangible  property  thereby arising with respect
          to the  Intellectual  Property.  No agreements or arrangements  are in
          effect with  respect to the  development,  non-disclosure,  marketing,
          distribution,  licensing or promotion of the Intellectual  Property by
          any independent contractor, salesperson,  distributor,  sublicensor or
          other remarketer or sales organization.

     3.9  Environmental Liability.

     (a)  Environmental  Substance Liability. No event has occurred or condition
          exists or has existed and no  operating  practice has been or is being
          employed  that could  reasonably  be expected to give rise to material
          liability on the part of the Company or any  Subsidiary  or any Person
          or entity for whose conduct the Company or any Subsidiary is or may be
          held responsible (together referred to in this subparagraph 3.9 as the
          "Company"),  under any  Environmental  Law  enacted on or prior to the
          date hereof as a result of or in connection with, the following:

          (i)  the using,  generating,  manufacturing,  refining,  transporting,
               treating, storing, handling, disposing, transferring,  producing,
               or processing of any Substances by the Company in or near or from
               the Facilities or any other  facilities owned or operated or used
               by the Company; or

          (ii) any intentional or unintentional  Release or Threat of Release of
               any  Substances  in, from or near  facilities of the Company into
               the Environment.

          (b)  Environmental  Compliance.  The  Company has  obtained  and is in
               material  compliance  with all applicable  Environmental  Law and
               with all registrations,  permits, licenses, approvals,  consents,
               orders, or authorizations  issued by or on behalf of any federal,
               state, or local  Governmental  Entity  ("Environmental  Permits")
               that are required  pursuant to  Environmental  Law in  connection
               with  construction  or operation of the  Facilities

                                       7

               or any  other  facilities  used or  owned by the  Company  or the
               generation,  treatment, storage,  transportation,  or disposal of
               any  Substances by the Company.  Such  Environmental  Permits are
               currently   effective  and   sufficient  for  the  ownership  and
               operation of the  Facilities and the operations of the Company as
               currently  conducted,  and the  Company  has no reason to believe
               that  there  is  any  basis  for   revocation,   suspension,   or
               modification of any such Environmental Permits.

          (c)  Offsite Disposal.  All Substances generated by the Company or the
               Facilities have been transported, stored, treated and disposed of
               by  carriers  or  treatment,   storage  and  disposal  facilities
               authorized or  maintaining  valid  permits  under all  applicable
               Environmental Law and the Company has no knowledge of any Release
               or Threat of Release at any offsite disposal facility used by the
               Company.

          (d)  Environmental  Liens.  No lien has been imposed on the Facilities
               by any Governmental Entity at the federal,  state, or local level
               in connection  with the presence on or off the  Facilities of any
               Substances;

          (e)  Environmental  Litigation.  The Company has not: (i) entered into
               or been  subject to any  consent  decree,  compliance  order,  or
               administrative  order  relating to the  Facilities  or operations
               thereon;  (ii) received  notice under the citizen suit provisions
               of any  Environmental  Law in connection  with the  Facilities or
               operations  thereon;  (iii) received any request for information,
               notice,  demand  letter,  administrative  inquiry,  or  formal or
               informal  complaint  or claim with  respect to any  Environmental
               Condition  on or off the  Facilities;  (iv)  been  subject  to or
               threatened with any  governmental or citizen  enforcement  action
               relating to the Facilities or any operations thereon; or (v) been
               subject to or  threatened  with any  personal  injury or property
               damage claims relating to any  Environmental  Condition on or off
               the Facilities, and the Company has no reason to believe that any
               of the above will be forthcoming.

          (f)  Underground Storage Tanks. There are no underground storage tanks
               at the Facilities.

          (g)  Asbestos-Containing  Materials.  To the knowledge of the Company,
               there are no  asbestos-containing  materials  at the New Facility
               and   to   the   knowledge   of   the   Company,   there   is  no
               asbestos-containing  material at the Current  Facility  for which
               the Company is or will be responsible under  Environmental Law or
               under any agreement with any third party or Governmental Entity.

          (h)  Environmental  Reports. The Company has provided to the Purchaser
               all reports,  audits, and assessments of Environmental Conditions
               relating to the  Facilities or operations  thereon,  and all such
               reports, audits, and assessments are listed on Schedule 3.9.

     3.10 Compliance with Laws; Regulatory Approvals. Except as disclosed in the
SEC  Reports  and except for  matters  which in the  aggregate  would not have a
Material Adverse Effect, the Company and its Subsidiaries are in compliance with
all applicable  laws.  Except for matters

                                       8

which in the aggregate,  as would not have a Material  Adverse  Effect,  (a) all
Regulatory  Approvals  required by the Company and its  Subsidiaries  to conduct
their respective business as now conducted by them have been obtained and are in
full force and effect and (b) the Company and its Subsidiaries are in compliance
with the terms and requirements of such Regulatory Approvals.

     3.11 Disclosure. All disclosures made in this Agreement are modified by any
information  set forth in the SEC  Reports.  Subject  to such  modification,  no
representation or warranty of the Company  contained in this Agreement  contains
any  untrue  statement  of a  material  fact or omits to state a  material  fact
necessary in order to make the statements  contained herein or therein, in light
of the circumstances under which they were made, not misleading.

     Section 4.Representations and Warranties of the Purchaser

     The Purchaser hereby represents and warrants to the Company as follows:

     4.1 Investment.  It will acquire the Shares and any other shares  purchased
from the Company  pursuant to this Agreement for investment for its own account,
not as a nominee or agent,  and not with a view to, or for resale in  connection
with, any  distribution  thereof.  It understands  that the Shares and any other
shares  purchased by the Purchaser  from the Company  pursuant to this Agreement
have not been,  and will not have been,  registered  under the Securities Act by
reason  of  a  specific  exemption  from  the  registration  provisions  of  the
Securities Act which depends upon,  among other things,  the bona fide nature of
Purchaser's   investment   intent   and   the   accuracy   of  the   Purchaser's
representations  as  expressed  herein.  By reason of its  business or financial
experience or the business or financial experience of its professional  advisors
who are  unaffiliated  with and who are not  compensated  by the  Company or any
affiliate or selling agent of the Company,  it directly or indirectly,  could be
reasonably  assumed  to  have  the  capacity  to  protect  its own  interest  in
connection with the purchase of the Shares from the Company at the Closing.

     4.2 Organization. The Purchaser is a corporation duly organized and validly
existing  in good  standing  under  the laws of the State of  Indiana,  with all
requisite corporate power and authority to own, lease and operate its properties
and assets and to carry on its business as presently  conducted  and as proposed
to be conducted.

     4.3 Authority.  The Purchaser has all corporate right,  power and authority
to enter into this  Agreement and to consummate  the  transactions  contemplated
hereby.  The execution  and delivery of this  Agreement by the Purchaser and the
consummation by the Purchaser of the transactions  contemplated hereby have been
duly  authorized by all necessary  corporate  action on behalf of the Purchaser.
This  Agreement  has been duly  executed  and  delivered  by the  Purchaser  and
constitutes a legal, valid and binding obligation of the Purchaser,  enforceable
against the Purchaser in accordance  with its terms,  subject to laws of general
application  relating to  bankruptcy,  insolvency  and the relief of debtors and
rules  of  law  governing  specific  performance,  injunctive  relief  or  other
equitable remedies,  and to limitations of public policy.  Subject to compliance
with such  filings as may be required to be made with the SEC and the NASD,  the
execution  and delivery of this  Agreement do not, and the  consummation  of the
transactions  contemplated  hereby  will  not,  conflict  with or  result in any
violation of any

                                       9


obligation under any provision of the Articles of Incorporation or Bylaws of the
Purchaser or any mortgage,  indenture,  lease or other  agreement or instrument,
license,  judgment,  order, decree, statute, law, ordinance,  rule or regulation
applicable to the Purchaser.

     4.4 Government Consents,  etc. No consent,  approval or authorization of or
designation,  declaration or filing with any Governmental  Entity on the part of
the Purchaser is required in connection with the valid execution and delivery of
this  Agreement,  the purchase of the Shares,  or the  consummation of any other
transaction  contemplated  hereby,  except such filings as may be required to be
made with the SEC and the NASD.

     4.5  Investigation.  The  Purchaser  has had a  reasonable  opportunity  to
discuss the  Company's  business,  management  and  financial  affairs  with the
Company's management and the Purchaser has received satisfactory  responses from
management of the Company to the Purchaser's inquiries.

     Section 5. Conditions to Obligations of Purchaser

     5.1 Conditions to Obligations of Purchaser.  The Purchaser's  obligation to
purchase the Shares at the Closing is, at the option of the Purchaser, which may
waive  any such  conditions  to the  extent  permitted  by law,  subject  to the
fulfillment on or prior to the Closing Date of the following conditions:

          (a)  Representations and Warranties  Correct.  The representations and
               warranties  made by the Company in Section 3 hereof shall be true
               and  correct  when  made,  and shall be true and  correct  on the
               Closing  Date with the same  force and effect as if they had been
               made on and as of said date.

          (b)  Covenants. All covenants,  agreements and conditions contained in
               this Agreement to be performed by the Company on or prior to such
               purchase  shall  have  been  performed  or  complied  with in all
               material respects.

          (c)  No Order  Pending.  There  shall not then be in effect  any order
               enjoining or restraining  the  transactions  contemplated by this
               Agreement.

          (d)  No Law Prohibiting or Restricting  Such Sale.  There shall not be
               in effect any law, rule or regulation  prohibiting or restricting
               such sale or  requiring  any  consent or  approval  of any person
               which shall not have been obtained to issue the Shares (except as
               otherwise provided in this Agreement).

          (e)  Opinion of Counsel.  Counsel to the Company shall have  delivered
               an  opinion of counsel  in form  reasonably  satisfactory  to the
               Purchaser,  in the form  normally  delivered  by such  counsel in
               connection with similar transactions.

     Section 6. Conditions to Obligations of Company

     6.1 Conditions to Obligations of Company.  The Company's obligation to sell
and issue the Shares at the Closing is, at the option of the Company,  which may
waive  any such

                                       10


conditions  to the extent  permitted by law,  subject to the  fulfillment  on or
prior to the Closing Date of the following conditions:

          (a)  Representations and Warranties  Correct.  The representations and
               warranties  made by the  Purchaser  in Section 4 hereof  shall be
               true and correct when made,  and shall be true and correct on the
               Closing  Date with the same  force and effect as if they had been
               made on and as of said date.

          (b)  Covenants. All covenants,  agreements and conditions contained in
               this  Agreement to be  performed by the  Purchaser on or prior to
               the Closing Date shall have been  performed  or complied  with in
               all material respects.

          (c)  No Order  Pending.  There  shall not then be in effect  any order
               enjoining or restraining  the  transactions  contemplated by this
               Agreement.

          (d)  No Law Prohibiting or Restricting  Such Sale.  There shall not be
               in effect any law, rule or regulation  prohibiting or restricting
               such sale or  requiring  any  consent or  approval  of any person
               which shall not have been obtained to issue the Shares (except as
               otherwise provided in this Agreement).

     Section 7. Covenants of the Company

     Until the  termination  of this  Agreement in accordance  with Section 11.1
hereof or of the particular covenant, as the case may be:

     7.1 No  Objection.  Provided the  Purchaser is in  compliance  with and has
performed all covenants,  agreements and conditions  contained in this Agreement
to be performed by the Purchaser,  the Company shall not interpose any objection
or take any legal action as a plaintiff in connection  with the  acquisition  by
the  Purchaser  of such number of shares of Common  Stock as is  permitted to be
owned  by the  Purchaser  pursuant  to this  Agreement  and the  Company  hereby
approves any such  acquisition in accordance  with the applicable  provisions of
the North Carolina Business Corporation Act.

     7.2 Sale of Shares.  The Company  shall take such  action as is  reasonably
necessary,  subject to  compliance  with  applicable  law, to issue and sell the
Shares to the Purchaser.

     7.3 Board of Directors.

          (a)  Board  Representation.  The Company shall be obligated to include
               in the slate of nominees  recommended  by the Company's  Board of
               Directors  or  management  to   shareholders,   for  election  as
               directors  at the  Company's  next meeting of  shareholders,  one
               person  designated by the Purchaser and reasonably  acceptable to
               Company (any such person, a "Purchaser Nominee") In addition,  if
               at any time the number of members  constituting  the entire Board
               of Directors shall equal or exceed nine,  including the Purchaser
               Nominee  appointed  pursuant  to  the  previous   sentence,   the
               Purchaser  shall be  entitled  to  designate  and the Board shall
               appoint  to  the  Board,  an  additional   Purchaser  Nominee  in
               accordance with the provisions

                                       11

               of  this  Section.  In  the  event  of a  vacancy  caused  by the
               disqualification,  removal,  resignation  or other  cessation  of
               service of any Purchaser  Nominee from the Board, the Board shall
               elect as a Director  (to serve  until the  Company's  immediately
               succeeding  annual  meeting  of  shareholders)  a  new  Purchaser
               Nominee who has been  designated by the Purchaser.  The Purchaser
               shall nominate each Purchaser  Nominee in advance of each meeting
               of shareholders at which such Purchaser Nominee is to be elected.
               Under no circumstances  shall any holder of the Company's capital
               stock (other than an  individual)  that  Beneficially  Owns fewer
               shares of the Voting Securities than the Purchaser be entitled to
               nominate, nor shall the Company nominate, more representatives of
               such  holder  to the Board of  Directors  than the  Purchaser  is
               entitled to nominate.

          (b)  Nominees.  Any  proposed  Purchaser  Nominee  shall  be a  person
               acceptable to the Board in its reasonable discretion prior to the
               initial  appointment,  or  election,  as the case may be, of each
               Purchaser  Nominee to the Board;  provided,  that at any time the
               President  or  Chief   Financial   Officer  of  the   Purchaser's
               Diagnostics  Division  or the Senior Vice  President  or the Vice
               President - Marketing of the Near Patient  Testing Segment of the
               Purchaser's  Diagnostics  Division,  each  shall be  conclusively
               deemed  to be  acceptable  to the  Board  for  purposes  of  this
               Section; and provided,  further, that once a Purchaser Nominee is
               accepted  by, or deemed  acceptable  to, the Board,  such  person
               shall thereafter be conclusively deemed to be acceptable pursuant
               to this Agreement  (together  with such persons  specified in the
               foregoing clauses (i) and (ii), the "Pre-Approved  Persons"). Any
               objection by the Company to a proposed  Purchaser Nominee must be
               made no  later  than  five  business  days  after  the  Purchaser
               delivers  written  notice  of  its  proposed  Purchaser  Nominee;
               provided, however, that the Company shall in all cases notify the
               Purchaser of any such  objection  sufficiently  in advance of the
               date on which  proxy  materials  are  mailed  by the  Company  in
               connection   with  such  election  of  directors  to  enable  the
               Purchaser to propose an alternate  Purchaser  Nominee pursuant to
               and in accordance with the terms of this Agreement.

          (c)  Election of  Directors.  The Company  agrees,  subject to Section
               7.3(b) above, to include such Purchaser Nominee to be added to or
               retained on the Board  pursuant to this Agreement in the slate of
               nominees  recommended by the Board to the Company's  shareholders
               for election as directors and shall use its reasonable efforts to
               cause the election or reelection of each such  Purchaser  Nominee
               to the  Board at each  meeting  of  shareholders  at  which  such
               Purchaser  Nominee  is  up  for  election,  including  soliciting
               proxies  in favor of the  election  of such  person(s),  it being
               understood  that  efforts  consistent  with  those used for other
               members  of the slate  recommended  by the Board  shall be deemed
               reasonable.

          (d)  Committees.  The Board will not establish an executive  committee
               authorized  to exercise the power of the Board  generally  unless
               the

                                       11


               Purchaser   is   granted   representation   on   such   committee
               proportional  to its  representation  on the Board,  nor will the
               Board  establish or employ  committees  (unless the  Purchaser is
               granted proportional  representation thereon) as a means designed
               to circumvent or having the effect of circumventing the rights of
               the  Purchaser  under this  Agreement  to  representation  on the
               Board.

          (e)  Termination.  The provisions of this Section 7.3 shall  terminate
               as at any time the  Purchaser  Beneficially  Owns less than 5% of
               the Voting Securities.

     7.4  Change in  Control.  In the event of a Change in Control as defined in
subsections (b), (d) and (e) of the definition  thereof,  if the price per share
to be paid to  shareholders  of the  Company  in  connection  with the Change in
Control  (the  "Change in Control  Price Per  Share") is less than the  Purchase
Price Per Share as to the Shares or $10.00 per share as to the  Original  Shares
and the  Purchaser is not in default under that certain  Distribution  Agreement
dated  as of  April  23,  2001  between  the  Company  and  the  Purchaser  (the
"Distribution  Agreement")  through the date of the Change in Control,  then the
Company shall be obligated to pay the Purchaser,  (a) for each of the Shares the
Purchaser then holds,  an amount equal to the Purchase Price Per Share minus the
Change in Control Price Per Share,  and (b) for each of the Original  Shares the
Purchaser  then holds,  an amount equal to $10.00 per  Original  Share minus the
Charge in Control  Price Per Share,  such amounts to be paid to the Purchaser in
addition to the Change in Control  Price Per Share to be received in  connection
with the Change in Control;  provided that this covenant  shall  terminate as to
any Proposal for a Change in Control  Transaction  initiated  after December 31,
2002,  except  with  respect  to  closing  of a  Proposal  or Change in  Control
Transaction initiated prior to December 31, 2002.

     7.5 Change in Control Transactions. In the event that the Company receives,
commences  negotiations  with respect to, or otherwise  obtains  knowledge of, a
Proposal,  it will promptly notify Purchaser and will provide  Purchaser with an
opportunity to propose a Change in Control Transaction in which the Purchaser or
an Affiliate thereof would be the acquiring company and, in connection therewith
will  provide  Purchaser  with all  information  and  equivalent  access  to the
management  and Board of  Directors  (including  any  committee  of the Board of
Directors  which  may be  formed  to  consider  such a  transaction)  as is made
available to any other Person making a Proposal. Notwithstanding anything to the
contrary  contained in this Section 7.5, the Company  shall have no  obligations
under this Section 7.5 to the extent that the Board of Directors determines that
complying with the obligations set forth in this Section 7.5 would  constitute a
breach of duty to the Company or the shareholders of the Company.

          7.6  Registration Rights.

               (a)  Demand Registration.

                    (i)  At any time on or after the date hereof, the Purchaser,
                         provided the  registration  rights  hereunder  have not
                         lapsed  as set  forth in  Section  7.6(i)  hereof,  may
                         demand   in   writing   that  the   Company   effect  a
                         registration  under  the  Securities  Act of all or any
                         portion  (but not less

                                       13


                         than Shares  with an  aggregate  fair  market  value of
                         $1,000,000);  provided, however, that the Purchaser may
                         request  registration  of  any  amount  of  Registrable
                         Securities  where the request  relates to all remaining
                         Registrable  Securities  for the purpose of sale in the
                         manner specified in such demand. Such demand shall also
                         specify the number of Registrable  Securities  that the
                         Purchaser  wishes to have so  registered.  The  Company
                         shall,  within 10 days of receipt of such demand,  give
                         written  notice of such demand to all other  holders of
                         the Company's  securities with contractual  rights on a
                         pari  passu  basis to have such  securities  registered
                         under the Securities  Act. Any such holder may,  within
                         30 days of its receipt of such notice from the Company,
                         give a written notice (the  "Inclusion  Notice") to the
                         Company   specifying   the  number  of  the   Company's
                         securities  which such holder wishes to include in such
                         registration.  The  Company  shall  prepare  and file a
                         registration   statement  on  any  available   form  of
                         registration  statement,  for  the  public  sale of the
                         Registrable   Securities   as  soon   as   practicable;
                         provided, however, that if the Company shall furnish to
                         the holders of  Registrable  Securities  (including the
                         Purchaser,  the "Participating  Holders") a certificate
                         signed by the  Chairman  or  President  of the  Company
                         stating that in the good faith judgment of the Board of
                         Directors of the Company, that such Demand Registration
                         would materially  interfere with, or require  premature
                         disclosure  of, any  material  financing,  acquisition,
                         reorganization or other material transaction  involving
                         the  Company  or  any  of its  Subsidiaries,  then  the
                         Company's  obligation to file a registration  statement
                         shall be deferred for a reasonable period not to exceed
                         180 days from the date of such request, but in no event
                         more than 180 days  during  any 24 month  period.  Upon
                         written  notice from the  Company to the  Participating
                         Holders  delivered  within  30  days  of  a  demand  to
                         register  Registrable  Securities  under  this  Section
                         7.6(a),  the Purchaser's  right to demand  registration
                         pursuant  to this  Section  7.6(a)  shall be  suspended
                         during the period  commencing  90 days  before the date
                         estimated  in writing by the  Company to be the date of
                         filing of a  registration  statement,  and  ending  six
                         months  following  the  effective  date (or  withdrawal
                         date) of a registration statement,  for an underwritten
                         public offering of the Common Stock.

                    (ii) All  Participating  Holders  (including  the Purchaser)
                         proposing  to   distribute   securities   through  such
                         registration shall enter into an underwriting agreement
                         with the managing or lead managing  underwriter in the

                                       14


                         form  customarily  used by such  underwriter  with such
                         changes  thereto as the parties thereto shall agree. If
                         any  Participating  Holder  disapproves of the terms of
                         any  such  underwriting,   it  may  elect  to  withdraw
                         therefrom  by  written  notice to the  Company  and the
                         managing or lead managing underwriter.  Any Registrable
                         Securities so withdrawn from such underwriting shall be
                         withdrawn from such registration.

                    (iii)Whenever a  registration  is demanded  pursuant to this
                         Section  7.6(a),  unless a  managing  or lead  managing
                         underwriter objects thereto, the Company may include in
                         such  registration   securities  for  offering  by  the
                         Company and any other  holder of  securities,  it being
                         understood,  however, that the Company's and such other
                         holder right of inclusion in such registration shall be
                         subordinate  to, and not pari passu with, the rights of
                         the Participating Holders.

                    (iv) If the managing underwriter thereof determines that the
                         total number of shares of Registrable  Securities to be
                         sold in such  offering  shall be limited  due to market
                         conditions  or  otherwise,  the  reduction in the total
                         number  of  shares  offered  shall  be  made  by  first
                         excluding  any shares of selling  stockholders  who are
                         not holders of  contractual  rights to have such shares
                         registered  under  the  Securities  Act and  shares  of
                         selling  stockholders  who are  holders of  contractual
                         rights  to  have  such  shares   registered  under  the
                         Securities  Act  that are  subordinate  to those of the
                         Participating    Holders    and   shares   of   selling
                         stockholders  who are holders of contractual  rights to
                         have such shares  registered  under the  Securities Act
                         that are  subordinate to those of the Purchaser,  then,
                         if necessary, by reducing the total number of shares to
                         be sold by the  Company,  and then,  if  necessary,  by
                         excluding pro rata (based on the number of  Registrable
                         Securities held) the Registrable  Securities to be sold
                         by the Participating Holders.

                    (v)  The  Participating  Holders  shall  have  the  right to
                         select the underwriter or  underwriters  and manager or
                         managers  to  administer   such   offering;   provided,
                         however,   that  each  Person  so  selected   shall  be
                         acceptable to the Company in its reasonable judgment.

                    (vi) The Company  shall be obligated to effect not more than
                         two Demand Registrations. For purposes of the preceding
                         sentence,  a Demand Registration shall not be deemed to
                         have been  effected  (i)  unless a Demand  Registration
                         Statement  with respect  thereto has become  effective,
                         (ii) if after such Demand  Registration  Statement  has
                         become effective, such Demand Registration Statement or
                         the related offer,  sale or distribution of Registrable
                         Securities  thereunder is  interfered  with by any stop
                         order,  injunction or other order or requirement of the
                         SEC or  other  governmental  agency  or  court  for any
                         reason not  attributable to the  Participating  Holders
                         and such  interference  is not  thereafter  eliminated,
                         (iii) if the  conditions  to closing  specified  in the
                         underwriting  agreement entered into in connection with

                                       15


                         such  registration  are not satisfied or waived,  other
                         than  by  reason  of a  failure  on  the  part  of  the
                         Participating  Holders  or (iv) the number of shares of
                         Registrable Securities to be sold by the Purchaser were
                         reduced  pursuant  to  Subsection  (iv)  above.  If the
                         Company shall have complied with its obligations  under
                         this  Agreement,  a  right  to  demand  a  registration
                         pursuant  hereto shall be deemed to have been satisfied
                         upon the earlier of (x) the date as of which all of the
                         Registrable Securities included therein shall have been
                         distributed   pursuant   to  the  Demand   Registration
                         Statement,  and (y) the  date as of which  such  Demand
                         Registration shall have been Continuously Effective for
                         a  60-day  period  or  other  period  specified  herein
                         following the effectiveness of such Demand Registration
                         Statement,  provided no stop order or similar order, or
                         proceedings for such an order, is thereafter entered or
                         initiated.

                    (vii)The  Company  shall  use  the  Company's   commercially
                         reasonable  efforts to keep the  relevant  registration
                         statement   Continuously   Effective,   if   a   Demand
                         Registration Statement, for up to 60 days or until such
                         earlier date as of which all the Registrable Securities
                         under the Demand Registration Statement shall have been
                         disposed of in the manner described in the Registration
                         Statement,  or such  longer  period  (but  in no  event
                         longer than 120 days) as in the judgment of counsel for
                         the  underwriters a prospectus is required by law to be
                         delivered  in  connection  with  sales  of  Registrable
                         Securities  by an  underwriter  or dealer in accordance
                         with  plan of  distribution  included  in  such  Demand
                         Registration Statement.  Notwithstanding the foregoing,
                         if  for  any  reason  the  effectiveness  of  a  Demand
                         Registration  Statement  pursuant to this Subsection is
                         delayed   or   suspended   or  filing  of  the   Demand
                         Registration Statement or seeking effectiveness thereof
                         is postponed as permitted  herein,  the commencement of
                         the foregoing period shall be extended by the aggregate
                         number of days of such suspension or postponement.

                    (viii) Except for registration  statements on Forms S-4, S-8
                         or any  successor  thereto,  the Company  will not file
                         with  the SEC any  other  registration  statement  with
                         respect  to its  capital  stock,  whether  for  its own
                         account or that of other stockholders, from the date of
                         receipt of a notice from requesting holders pursuant to
                         this Section 7.6 until the  completion of the period of
                         distribution of the registration contemplated thereby.

          (b)  Registration Statement Information Relating to the Purchaser. The
               Purchaser  shall promptly upon receipt of written request provide
               the  Company  or any  underwriter  or  counsel  participating  or
               otherwise  involved in any such registration with any information

                                       16

               relating to the Purchaser or the  Registrable  Securities that is
               reasonably required to be included in the registration  statement
               or the  prospectus,  or any amendment  thereof,  relating to such
               offering or required to cause the registration to be declared and
               remain effective. Such information shall be submitted in writing,
               signed by the Purchaser,  or a duly authorized  representative or
               agent thereof,  and shall state that the information is submitted
               specifically  for the purpose of  inclusion  in the  registration
               statement,   prospectus,  offering  circular  or  other  document
               related to the  registration or  qualification of the Registrable
               Securities  pursuant  hereto.  If the  Purchaser  fails  within a
               reasonable  time to provide  such  information,  the  Company may
               exclude  from  such   registration  the  Registrable   Securities
               requested by the Purchaser to be included therein.

          (c)  Registration Procedures.  If and whenever the Company is required
               to effect the  registration of any Registrable  Securities of the
               Purchaser pursuant hereto, the Company will:

               (i)  prepare and file with the SEC a registration  statement with
                    respect to such  Registrable  Securities  and use reasonable
                    efforts to cause such  registration  statement to become and
                    remain effective as provided herein; provided, however, that
                    before filing a Demand Registration  Statement or prospectus
                    or  any   amendments  or  supplements   thereto,   including
                    documents incorporated by reference after the initial filing
                    of  the   Demand   Registration   Statement   and  prior  to
                    effectiveness  thereof, the Company shall furnish to counsel
                    for the  Purchaser  and  underwriters,  copies  of all  such
                    documents in the form  substantially as proposed to be filed
                    with the SEC at a reasonable time prior to filing for review
                    and comment by such counsel;

               (ii) prepare   and  file  with  the  SEC  such   amendments   and
                    supplements  to such Demand  Registration  Statement and the
                    prospectus used in connection with such Demand  Registration
                    Statement as may be necessary to comply with the  provisions
                    of the Securities Act and rules  thereunder  with respect to
                    the  distribution  of all securities  covered by such Demand
                    Registration Statement and as may be reasonably requested by
                    the Purchaser or necessary to keep such Demand  Registration
                    Statement   effective.   If  the   registration  is  for  an
                    underwritten  offering,  the Company  shall amend the Demand
                    Registration Statement or supplement the prospectus whenever
                    required by the terms of the underwriting agreement. Pending
                    such  amendment or  supplement  the  Purchaser and all other
                    members of the Purchaser  Group,  upon written notice by the
                    Company,   shall  cease   making   offers  or  Transfers  of
                    Registrable Securities pursuant to the prior prospectus.  In
                    the event  that any  Registrable  Securities  included  in a
                    Demand  Registration  Statement  subject to, or required by,
                    this Agreement remain unsold at the end of the period during

                                     17


                    which  the  Company  is  obligated  to use its  commercially
                    reasonable  efforts to maintain  the  effectiveness  of such
                    Demand  Registration  Statement,  the  Company  may  file  a
                    post-effective   amendment   to  the   Demand   Registration
                    Statement for the purpose of removing such  securities  from
                    registered status;

               (iii)notify the  Purchaser and the  Underwriters'  Representative
                    and (if requested)  confirm such advise in writing,  as soon
                    as  practicable  after  notice  thereof is  received  by the
                    Company (i) when the Demand  Registration  Statement  or any
                    amendment thereto has been filed or becomes  effective,  the
                    prospectus or any amendment or supplement to the  prospectus
                    included  therein  has  been  filed,  and,  to  furnish  the
                    Purchaser and the underwriters with copies thereof,  (ii) of
                    any request by the SEC for  amendments or supplements to the
                    Demand  Registration  Statement or the  prospectus  included
                    therein or for additional information,  (iii) if at any time
                    the  representations  and warranties of the Company cease to
                    be true and correct,  and (iv) of the receipt by the Company
                    of  any  notification  with  respect  to the  suspension  or
                    qualification of the Registrable  Securities for offering or
                    sale in any jurisdiction or the initiation or threatening of
                    any proceeding for such purpose;

               (iv) immediately  notify  the  Purchaser,  at  any  time  when  a
                    prospectus  relating  thereto is  required  to be  delivered
                    under the Securities Act, of the happening of any event as a
                    result of which the prospectus  included in the registration
                    statement,  as then in effect,  includes an untrue statement
                    of a  material  fact or  omits to state  any  material  fact
                    required  to be  stated  therein  or  necessary  to make the
                    statements  therein  not  misleading  in  the  light  of the
                    circumstances then existing, and if it is necessary,  in the
                    opinion of counsel to the Company,  to prepare and file with
                    the SEC such amendments and supplements to such registration
                    statement and the prospectus used in connection therewith as
                    may  be  necessary  to  keep  such  registration   statement
                    effective  and current and to comply with the  provisions of
                    the  Securities  Act  with  respect  to the  sale  or  other
                    disposition  of all  shares  covered  by  such  registration
                    statement,  including such amendments and supplements as may
                    be necessary to reflect the intended  method of  disposition
                    from time to time of the  Purchaser if the  registration  is
                    effected  in  connection  with  an  offering  which  is  not
                    underwritten;

               (v)  cooperate   with  the   Purchaser   and  the   Underwriters'
                    Representatives  to facilitate  the timely  preparation  and
                    delivery of certificates representing Registrable Securities
                    to be sold and not  bearing  any  restrictive  legends;  and
                    enable   such   Registrable   Securities   to  be  in   such
                    denomination   and   registered   in  such   names   as  the

                                     18


                    Underwriters'   Representative  may  request  at  least  two
                    business days prior to the sale of Registrable Securities to
                    the underwriters;

               (vi) cooperate with the Purchaser in connection  with any filings
                    required  to be made with the NASD,  and  otherwise  use its
                    best   efforts  to  comply  with  the  rules,   by-laws  and
                    regulations of the NASD as they apply to the registration;

               (vii)furnish  to  the  Purchaser  such  number  of  copies  of  a
                    prospectus,  including  a  preliminary  prospectus  and  any
                    amendments and any supplements  thereto,  in conformity with
                    the requirements of the Securities Act, as the Purchaser may
                    reasonably request in order to facilitate the public sale or
                    other disposition of the Registrable Securities owned by the
                    Purchaser;

               (viii)  use  reasonable   efforts  to  register  or  qualify  the
                    Registrable   Securities   covered   by  such   registration
                    statement  under such other  securities or blue sky or other
                    applicable  laws of such  jurisdictions  within  the  United
                    States as the Purchaser shall  reasonably  request to enable
                    the  Purchaser  to  consummate  the  public  sale  or  other
                    disposition  of  the  Registrable  Securities  owned  by the
                    Purchaser,  and  to  obtain  the  withdrawal  of  any  order
                    suspending  the  effectiveness  of  a  Demand   Registration
                    Statement,   or  the  lifting  of  any   suspension  of  the
                    qualification (or exemption from qualification) of the offer
                    and  Transfer of any of the  Registrable  Securities  in any
                    jurisdiction,  at the earliest possible moment;  except that
                    the Company  shall not for any such  purpose be required (i)
                    to qualify generally to do business as a foreign corporation
                    in any  jurisdiction in which it would not be required to so
                    qualify but for such registration or qualification,  (ii) to
                    subject  itself to  taxation  in any such  jurisdiction,  or
                    (iii) to consent  to general  service of process in any such
                    jurisdiction;

               (ix) use its best  efforts to furnish  to the  Purchaser  who has
                    included   Registrable   Securities   in  the   registration
                    statement a signed counterpart,  addressed to the Purchaser,
                    of (A) an opinion of counsel for the Company, dated the date
                    of the closing under the underwriting  agreement,  and (B) a
                    "cold  comfort"  letter  signed  by the  independent  public
                    accountants  who  have  issued  a  report  on the  Company's
                    financial statements included in such registration statement
                    dated  the  date  of   effectiveness   of  the  registration
                    statement and the date of the closing under the underwriting
                    agreement,  covering  substantially  the same  matters  with
                    respect to such  registration  statement (and the prospectus
                    included  therein)  and,  in the  case of such  accountants'
                    letters,  with respect to events  subsequent  to the date of
                    such financial  statements,  as are  customarily  covered in

                                       19


                    opinions of issuer's  counsel  and in  accountants'  letters
                    delivered to underwriters in underwritten  public  offerings
                    of securities and, in the case of the accountants'  letters,
                    such other financial matters as the Purchaser may reasonably
                    request;

               (x)  otherwise use its best efforts to comply with all applicable
                    rules and  regulations of the SEC, and make available to its
                    security  holders,  as soon as  reasonably  practicable,  an
                    earnings  statement  covering  the  period  of at  least  12
                    months,  beginning  with the first month of the first fiscal
                    quarter  after  the  effective  date  of  such  registration
                    statement,   which  earnings  statement  shall  satisfy  the
                    provisions of Section 11(a) of the Securities Act;

               (xi) use its best efforts to list such Registrable  Securities on
                    each securities exchange or over-the-counter market on which
                    shares of Common Stock are then listed,  if such Registrable
                    Securities  are not already so listed and if such listing is
                    then  permitted  under the rules of such  exchange  and,  if
                    shares of Common  Stock are not then listed on a  securities
                    exchange or over-the-counter market, to use its best efforts
                    to cause such  Registrable  Securities  to be listed on such
                    securities  exchange  or  over-the-counter   market  as  the
                    managing  or  lead  managing  underwriter  shall  reasonably
                    request;

               (xii)use its  best  efforts  to  provide  a  transfer  agent  and
                    registrar for such Registrable Securities not later than the
                    effective date of such registration statement;

               (xiii)if requested by the managing or lead  managing  underwriter
                    for any underwritten  offering that includes any Registrable
                    Securities,  enter into an  underwriting  agreement with the
                    underwriters  of such  offering,  such  agreement to contain
                    such  representations and warranties by the Company and such
                    other terms and conditions as are contained in  underwriting
                    agreements   customarily  used  by  such  managing  or  lead
                    managing  underwriter  with  such  changes  as  the  parties
                    thereto   shall  agree,   including,   without   limitation,
                    provisions  relating to indemnification  and contribution in
                    lieu thereof;

               (xiv)cooperate   with  the  Purchaser,   and  the   Underwriters'
                    Representative  for  such  offering  in the  marketing,  and
                    customary   selling  efforts  relating  to  the  Registrable
                    Securities,  including  participating  for a  period  not in
                    excess of five (5) business days per Demand  Registration in
                    customary  "road show"  presentations  as may be  reasonably
                    requested by the Underwriters' Representative;

               (xv)promptly  notify the  Purchaser  of any stop order  issued or
                    threatened to be issued by the SEC in  connection  therewith

                                       20
                    and take all  reasonable  actions  required  to prevent  the
                    entry of such stop order or to remove it if entered; and

               (xvi)make  available  for   inspection  by  the  Purchaser,   any
                    underwriter   participating   in  such   offering   and  the
                    representatives  of the Purchaser and such  underwriter  all
                    financial  and  other  information  as shall  be  reasonably
                    requested   by  them,   and  provide  the   Purchaser,   any
                    underwriter   participating   in  such   offering   and  the
                    representatives  of the Purchaser and such  underwriter  the
                    reasonable  opportunity  to discuss the business  affairs of
                    the Company with its principal  executives  and  independent
                    public  accountants who have certified the audited financial
                    statements included in such registration  statement, in each
                    case all as necessary  to enable them to exercise  their due
                    diligence   responsibilities   under  the  Securities   Act;
                    provided,   however,   that  information  that  the  Company
                    determines, in its reasonable and good faith judgment, to be
                    confidential  and which the Company  advises  such Person in
                    writing,  is confidential shall not be disclosed unless such
                    Person   signs  a   confidentiality   agreement   reasonably
                    satisfactory to the Company.

     (d)  Termination of Sales.  During the effective period of any registration
          statement  covering  Registrable  Securities,  the Purchaser  will not
          effect sales thereof after receipt of  telegraphic  or written  notice
          from the Company to suspend  sales to permit the Company to correct or
          update a  registration  statement or  prospectus  until the  Purchaser
          receives  written  notice  from  the  Company  that  the  registration
          statement or prospectus has been  corrected or updated.  At the end of
          the  effective  period  of any  registration  statement  covering  any
          Registrable  Securities,  the  Purchaser  shall  discontinue  sales of
          shares pursuant to such registration  statement upon receipt of notice
          from the  Company of its  intention  to remove from  registration  the
          shares covered by such registration statement which remain unsold, and
          the  Purchaser  shall  notify  the  Company  of the  number  of shares
          registered which remain unsold immediately upon receipt of such notice
          from the Company.

     (e)  Expenses of  Registration.  With  respect to the Demand  Registrations
          effected pursuant to Subsection (a) hereof, the Company shall bear and
          pay all expenses incurred in connection with any registration, filing,
          or qualification of Registrable Securities with respect to such Demand
          Registration,  including all  registration,  filing and NASD fees, all
          fees and expenses of complying  with  securities or blue sky laws, all
          word  processing,  duplicating  and printing  expenses,  messenger and
          delivery  expenses,  and the  reasonable  fees  and  disbursements  of
          counsel  for the  Company,  and of the  Company's  independent  public
          accountants, including the expenses of "cold comfort" letters required
          by or incident to such  performance and compliance (the  "Registration
          Expenses"),  but in no  event  shall  the  Company  bear  underwriting

                                       21

          discounts and commissions  relating to Registrable  Securities or fees
          and expenses of the  Purchaser's  counsel  (which shall be paid by the
          Purchaser)  and provided that the Company shall not be required to pay
          for any expenses of any registration  begun pursuant to Subsection (a)
          if the  registration is  subsequently  withdrawn at the request of the
          Purchaser (in which case the Purchaser shall bear such expense), other
          than by reason of failure of the Company to comply with its  covenants
          contained  herein  unless the  Purchaser  agrees  that such  withdrawn
          registration  shall constitute one of the Demand  Registrations  under
          Subsection (a) hereof.

     (f)  Indemnification.

          (i)  In any  registration  in which the  Purchaser  participates,  the
               Company will  indemnify the Purchaser  and each  underwriter  and
               selling broker for the Purchaser and each officer and director of
               the Purchaser and each person, if any, who controls the Purchaser
               or any such  underwriter  or broker within the meaning of Section
               15 of the Securities Act,  against all claims,  losses,  damages,
               expenses  and  liabilities  (or  actions  in  respect   thereof),
               including  any of the  foregoing  incurred in  settlement  of any
               litigation,  commenced or threatened,  arising out of or based on
               any untrue statement (or alleged untrue  statement) of a material
               fact   contained  in  any   preliminary   prospectus  or  amended
               preliminary prospectus or in the prospectus, offering circular or
               other document  incident to any  registration,  qualification  or
               compliance   (or   in   any   related   registration   statement,
               notification  or the like) as such may be amended or supplemented
               from time to time or any omission (or alleged  omission) to state
               therein  a  material  fact  required  to  be  stated  therein  or
               necessary  to  make  the  statements  therein,  in  light  of the
               circumstances under which they were made, not misleading,  or any
               violation  by the  Company of the  Securities  Act or any rule or
               regulation promulgated thereunder or any state securities laws or
               regulations applicable to the Company in connection with any such
               registration, qualification or compliance, and will reimburse the
               Purchaser  and each  such  underwriter,  broker  and  controlling
               person for any legal and any other expenses reasonably  incurred,
               as such expenses are incurred,  in connection with  investigating
               or defending any such claim, loss,  damage,  liability or action;
               provided,  however,  that the  Company  will not be liable in any
               such case to the  extent  that any such  claim,  loss,  damage or
               liability  arises out of or is based on any untrue  statement  or
               omission  made in reliance  upon and in  conformity  with written
               information furnished to the Company in an instrument executed by
               the  Purchaser  or  the  underwriter  for  the  Purchaser  or any
               representative  of the  Purchaser  or  the  underwriter  for  the
               Purchaser and stated to be specifically for use therein.

                                       22


          (ii) In any  registration  in which the  Purchaser  participates,  the
               Purchaser  will  indemnify  the  Company  and  its  officers  and
               directors,  each person,  if any, who controls any thereof within
               the  meaning  of  Section  15 of the  Securities  Act  and  their
               respective  successors  and any  underwriter  for the Company for
               such registration and each other security holder participating in
               the registration against all claims,  losses,  damages,  expenses
               and liabilities (or actions in respect thereof) arising out of or
               based on any untrue statement (or alleged untrue  statement) of a
               material fact contained in any preliminary  prospectus or amended
               prospectus  or in the  prospectus,  offering  circular  or  other
               document incident to any registration statement, qualification or
               compliance   (or   in   any   related   registration   statement,
               notification  or the like) as such may be amended or supplemented
               from time to time or any omission (or alleged  omission) to state
               therein  a  material  fact  required  to  be  stated  therein  or
               necessary  to  make  the  statements  therein,  in  light  of the
               circumstances  under which they were made,  not  misleading,  and
               will  reimburse  the  Company and each other  person  indemnified
               pursuant  to this  paragraph  (ii) for any  legal  and any  other
               expenses reasonably incurred,  as such expenses are incurred,  in
               connection with  investigating or defending any such claim, loss,
               damage,  liability  or  action;  provided,   however,  that  this
               paragraph  (ii) shall apply only if (and only to the extent that)
               such  statement  or  omission  was made in  reliance  upon and in
               conformity   with   written   information   (including,   without
               limitation, written negative responses to inquiries) furnished to
               the  Company   specifically  for  inclusion  in  the  prospectus,
               offering circular, or other document incident to the registration
               statement by an instrument  duly executed by the Purchaser or its
               representatives,  and as to  which  the  Company  had  no  actual
               knowledge.  Notwithstanding  the foregoing,  the liability of the
               Purchaser under this paragraph (ii) shall be limited to an amount
               equal to the aggregate  proceeds  received by the Purchaser  from
               the  sale  of  its  shares  in  such  registration,  unless  such
               liability arises out of or is based on willful  misconduct by the
               Purchaser.

          (iii)Each   party   entitled   to   indemnification   hereunder   (the
               "Indemnified  Party") shall give notice to the party  required to
               provide indemnification (the "Indemnifying Party") promptly after
               such  Indemnified  Party has actual  knowledge of any claim as to
               which indemnity may be sought,  and shall permit the Indemnifying
               Party (at its  expense) to assume the defense of any claim or any
               litigation  resulting  therefrom,  provided  that counsel for the
               Indemnifying  Party,  who shall conduct the defense of such claim
               or litigation,  shall be satisfactory  to the Indemnified  Party,
               and the Indemnified Party may participate in such defense at such
               party's expense, and provided,  further, that the omission by any
               Indemnified  Party to give  notice as provided  herein  shall not
               relieve  the  Indemnifying  Party of its  obligations  under this

                                       23


               Section  7.6(f)  except to the extent that the  omission  results
               from a failure of actual notice to the Indemnifying  Party by the
               Indemnified Party and such  Indemnifying  Party is damaged solely
               as a result of the failure to give notice;  and provided further,
               however,  that the  Indemnifying  Party  shall not be entitled to
               assume  the  defense  for  matters  as to which  there is, in the
               opinion of  counsel  to the  Indemnified  Party,  a  conflict  of
               interest or separate  and  different  defenses.  No  Indemnifying
               Party,  in the  defense of any such claim or  litigation,  shall,
               except with the  consent of each  Indemnified  Party,  consent to
               entry of any judgment or enter into any settlement which does not
               include  as an  unconditional  term  thereof  the  giving  by the
               claimant or plaintiff to such Indemnified Party of a release from
               all liability in respect of such claim or litigation.

          (iv) The  payments  with  respect to any  indemnity  required  by this
               Section  7.6(f)  shall be made by  periodic  payments  during the
               course of the  investigation  or  defense,  as and when bills are
               received or expenses  incurred,  upon  submission  of  supporting
               invoices or other claims for payment,  including any calculations
               necessary  to  pro-rate  any  amounts  payable  pursuant  to  the
               indemnity.

     (g)  Contribution.

          (i)  If the  indemnification  provided for in Section 7.6(f) hereof is
               unavailable to the Indemnified  Parties in respect of any losses,
               claims,  damages,  liabilities or expenses (or actions in respect
               thereof) referred to therein,  then each such Indemnifying Party,
               in lieu of indemnifying such Indemnified  Party, shall contribute
               to the  amount  paid or payable  by such  Indemnified  Party as a
               result of such losses, claims,  damages,  liabilities or expenses
               (or  actions  in  respect  thereof)  in  such  proportion  as  is
               appropriate  to reflect the  relative  fault of the  Indemnifying
               Party on the one hand and the  Indemnified  Party on the other in
               connection  with the statement or omission which resulted in such
               losses, claims,  damages,  liabilities or expenses (or actions in
               respect  thereof),  as  well  as  any  other  relevant  equitable
               considerations.   The  relative  fault  shall  be  determined  by
               reference  to, among other things,  whether the untrue  statement
               (or alleged untrue  statement) of a material fact or the omission
               (or  alleged  omission)  to  state a  material  fact  relates  to
               information supplied by the Indemnifying Party or the Indemnified
               Party and the  parties'  relative  intent,  knowledge,  access to
               information  and opportunity to correct or prevent such statement
               or omission.  The Company and each Purchaser  agree that it would
               not be  just  and  equitable  if  contribution  pursuant  to this

                                       24

               Section 7.6(g) were  determined by pro rata  allocation or by any
               other  method of  allocation  which does not take  account of the
               equitable  considerations  referred to above.  The amount paid or
               payable  by an  Indemnified  Party  as a  result  of the  losses,
               claims,  damages,  liabilities or expenses (or actions in respect
               thereof)  referred to above in this Section  7.6(g) or in Section
               7.6(f)  shall be deemed to  include  any legal or other  expenses
               reasonably  incurred by such Indemnified Party in connection with
               investigating or defending any such action or claim.

          (ii) Notwithstanding  anything to the contrary  contained herein,  the
               obligation  of the  Purchaser  to  contribute  pursuant  to  this
               Section 7.6(g ) is several and not joint and the Purchaser  shall
               not be required to contribute  any amount in excess of the amount
               by which the total  price at which  the  shares of the  Purchaser
               were  offered to the  public  exceeds  the amount of any  damages
               which the Purchaser has otherwise  been required to pay by reason
               of  such  untrue  statement  (or  alleged  untrue  statement)  or
               omission (or alleged omission).

          (iii)No person  guilty of  fraudulent  misrepresentation  (within  the
               meaning  of  Section  11 (f)  of the  Securities  Act)  shall  be
               entitled  to  contribution  from any person who was not guilty of
               such fraudulent misrepresentation.

          (h)  Rule 144  Requirements.  The Company shall make whatever  filings
               with  the  SEC  or  otherwise  and  undertake  to  make  publicly
               available and available to the Purchaser, pursuant to Rule 144 of
               the SEC  under  the  Securities  Act (or  any  successor  rule or
               regulation),  such  information  as is  necessary  to enable  the
               Purchaser  to make sales of  Registrable  Securities  pursuant to
               that Rule.  The  Company  shall  furnish to the  Purchaser,  upon
               request,  a written  statement  executed by the Company as to the
               steps it has taken to comply with the current public  information
               requirements of Rule 144.

          (i)  Survival and Termination of Rights.  The agreements and covenants
               contained  in this  Section  7.6  shall be  continuing  and shall
               survive any Transfer of the Shares to any member of the Purchaser
               Group.  However, the rights of the Purchaser to cause the Company
               to register its Registrable  Securities hereunder shall terminate
               with  respect to such  securities  and such  securities  shall no
               longer be deemed to be  Registrable  Securities  following a bona
               fide,  firmly  underwritten  public offering of such  Registrable
               Securities  under  the  Securities  Act or at  such  time  as the
               Purchaser is able to dispose of all of its Registrable Securities
               in one three-month period pursuant to the provisions of Rule 144.

                                       25


          (j)  Sales During  Registration.  If so requested by the Underwriters'
               Representative  in connection with an offering of any Registrable
               Securities,  the  Company  shall  agree not to effect any sale or
               distribution  of shares of Common  Stock  during the 7-day period
               prior to, and during the  90-day  period  beginning  on, the date
               such Demand  Registration  Statement is declared  effective under
               the  Securities  Act by the SEC.  The  Company  agrees to use its
               commercially  reasonable  efforts to obtain  from each  holder of
               restricted  securities  of the  Company the same as or similar to
               those being registered by the Company on behalf of the Purchaser,
               or any restricted securities  convertible into or exchangeable or
               exercisable for any of its securities, an agreement not to effect
               any  sale  or  distribution   of  such  securities   (other  than
               securities  purchased  in a public  offering)  during  any period
               referred to in this paragraph,  except as part of any such Demand
               Registration   Statement  if  permitted.   Without  limiting  the
               foregoing,  if the Company grants any Person (other than a holder
               of Registrable Securities) any rights to demand or participate in
               a  Registration,  the  Company  agrees  that the  agreement  with
               respect   thereto  shall  include  such  Person's   agreement  as
               contemplated by the previous sentence.

          (k)  Granting of Registration Rights.  Notwithstanding anything to the
               contrary  contained  herein,  the Company shall not,  without the
               prior written consent of the Purchaser Group, grant any rights to
               any  Persons to  register  any  shares of capital  stock or other
               securities  of the Company if such  rights  could  reasonably  be
               expected to be superior  to or be on parity  with,  the rights of
               the holders of Registrable  Securities  granted  pursuant to this
               Agreement  upon  the  exercise  of  Demand   Registration  rights
               contained herein.

     7.7 No  Restrictions.  The Company will not, prior to January 1, 2003, make
or recommend to its  shareholders  any  amendment to the  Company's  Articles of
Incorporation  or Bylaws which would impose  limitations  on the legal rights of
the Purchaser Group as Company  shareholders  (other than those imposed pursuant
to this Agreement) based upon the size of security holding  permitted under this
Agreement,  the  business  in  which a  security  holder  is  engaged  or  other
considerations  applicable  to the Purchaser  Group and not to security  holders
generally.

     7.8  Share  Listing.  As  soon  as  practicable,  the  Company  shall  take
reasonable action as is required to cause the Shares to be listed for trading on
The NASDAQ Stock Market ("NASDAQ").

     7.9  Preemptive  Rights.  The Company  shall,  prior to any issuance by the
Company of any of its  securities  (other  than debt  securities  with no equity
feature),  offer to the Purchaser by written  notice the right,  for a period of
thirty (30) days,  to purchase the  Purchaser's  Pro Rata Share (as such term is
defined  below)  of such  securities  for cash at a price  equal to the price or
other  consideration  for which  such  securities  are to be  issued;  provided,
however,  that the preemptive  rights of the Purchaser  pursuant to this Section
7.9 shall not apply to  securities  issued (A) upon  conversion of any shares of

                                       26


the Preferred  Stock  outstanding on the Closing Date (B) as a stock dividend or
upon any  subdivision  of shares of Common Stock,  provided that the  securities
issued  pursuant to such stock dividend or subdivision are limited to additional
shares of Common Stock, (C) pursuant to options or other rights which are issued
pursuant to the 1994 or 1995 Stock Option Plans or any similar plan  approved by
the Board of  Directors  of the  Company  and the  holders of Voting  Securities
within one year of such Board approval or (D) in payment of dividend obligations
on the Preferred  Stock.  The Company's  written  notice to the Purchaser  shall
describe  the  securities  proposed  to be issued by the Company and specify the
number, price and payment terms. The Purchaser may accept the Company's offer as
to the full number of  securities  offered to it or any lesser number by written
notice  thereof  given  by it to the  Company  prior  to the  expiration  of the
aforesaid thirty (30) day period, in which event the Company shall promptly sell
and the Purchaser shall buy, upon the terms specified,  the number of securities
agreed to be purchased by the  Purchaser.  For purposes of this Section 7.9, the
Purchaser's  "Pro Rata  Share" of  offered  securities  shall be  determined  by
multiplying the full number of securities  offered by the Company by a fraction,
the numerator of which shall be the number of shares of Common Stock held by the
Purchaser as of the date of the Company's notice of offer and the denominator of
which shall be the  aggregate  number of shares of Common Stock  (calculated  as
aforesaid) held on such date by all holders of capital stock of the Company. The
Company shall be free at any time following  expiration of the thirty-day  offer
period  and prior to ninety  (90) days  after the  expiration  of the thirty day
offer period,  to offer and sell to any third party or parties the number of the
securities not agreed by the Purchaser to be purchased by it, all at a price and
on payment terms no less  favorable to the Company than those  specified in such
notice of offer to the Purchaser. However, if such third party sale or sales are
not consummated  within such ninety (90) day period,  the Company shall not sell
such  securities  as shall not have been  purchased  within such period  without
again complying with this Section 7.9.

     7.10 Share Buyback. In the event the Company or any of its Affiliates shall
repurchase  shares  of  Voting  Securities,  including  any  redemption  of  the
Preferred  Stock,  the Company  shall offer to purchase such number of shares of
Voting  Securities  as would be  necessary  on a pro rata  basis to ensure  that
Purchaser as an "other entity" does not exceed 20%  Beneficial  Ownership of the
Company's  "Voting Shares" within the meaning of the North Carolina  Shareholder
Protection Act. The purchase price per share of such Voting  Securities shall be
the Average  Market Price as of the date of the  Purchaser's  acceptance  of the
offer to purchase.

     Section 8. Covenants of the Purchaser

     Until the  termination  of this  Agreement in accordance  with Section 11.1
hereof or of the particular covenant, as the case may be:

          8.1  Limitation on Ownership of Voting Securities.

          (a)  The Purchaser  shall not (and shall not permit any  Subsidiary to
               directly  or  indirectly)  acquire  Beneficial  Ownership  of any
               Voting  Securities,   or  any  other  rights  to  acquire  Voting
               Securities  (except,  in any case,  by way of stock  dividends or
               other distributions or offerings made available to holders of any
               Voting  Securities  generally)  or  authorize  or make a  tender,

                                       27


               exchange  or other  offer,  without  the  written  consent of the
               Company,  if the effect of such acquisition  would be to increase
               the  Voting  Power of all  Voting  Securities  then  owned by the
               Purchaser or which it has a right to acquire to more than 20 % of
               the Total Voting Power of the Company.

          (b)  Nothing in Section 8.1 (a) above shall prevent the Purchaser from
               acquiring Voting Securities  without regard to the limitation set
               forth therein (i) if an offer is made (as evidenced by the filing
               with the SEC of a  Schedule  14D-1)  by  another  person or group
               (which is not  controlled  by or under  common  control  with the
               Purchaser)   to   purchase   or   exchange   for  cash  or  other
               consideration any Voting  Securities which, if successful,  would
               result  in such  Person or group  owning  or having  the right to
               acquire  more than 20 % of the Total  Voting Power of the Company
               then in effect and such  offer is not  withdrawn,  terminated  or
               enjoined prior to the Purchaser  acquiring  Voting  Securities in
               response  thereto,  or (ii) if it is  publicly  disclosed  or the
               Purchaser  otherwise  learns  that  another  Person  or group has
               acquired  any Voting  Securities  (or  rights to  acquire  Voting
               Securities)  which  results  in such  Person  or group  owning or
               having the right to acquire Voting  Securities  that would result
               in a Total Ownership  Percentage of not less than 20 % or (iii) a
               Proposal  for a  Change  in  Control  Transaction  is made to the
               Company other than by the Purchaser.

     8.2 Voting.  The Purchaser shall vote all shares of Voting Securities which
it  Beneficially  Owns, at any  shareholder  meeting or in  connection  with any
action by written  consent at or in which such shares of Voting  Securities  are
entitled to vote, (a) in favor of the slate of nominees (including any Purchaser
Nominee to be included in such slate in accordance with Section 7.3) proposed by
the Board,  provided  that the Company has complied with Section 7.3, and (b) on
any non-Company  sponsored shareholder proposal which is opposed by the Company,
in  accordance  with the  direction of the Board as to how such shares of Voting
Securities  shall be voted. On all other matters the Purchaser shall be entitled
to vote the Voting  Securities held by it in its discretion.  The Purchaser,  as
the holder of shares of Voting  Securities,  shall be  present,  in person or by
proxy,  at all  meetings  of  shareholders  of the Company so that all shares of
Voting  Securities  beneficially  owned by the  Purchaser may be counted for the
purposes of determining the presence of a quorum at such meetings.

     8.3 Voting Trust, etc. The Purchaser shall not deposit any shares of Voting
Securities in a voting trust or, except as otherwise  provided  herein,  subject
any Voting Securities to any arrangement or agreement with respect to the voting
of such Voting Securities.

     8.4  Solicitation of Proxies.  The Purchaser shall not solicit proxies with
respect to any Voting  Securities,  and shall not become a "participant"  in any
"election  contest"  (as such terms are used in Rule  14a-11 of  Regulation  14A
under the Exchange Act relating to the election of directors of the Company).

     8.5 Acts in Concert  with  Others.  The  Purchaser  Group  shall not join a
partnership, limited partnership,  syndicate or other group, or otherwise act in
concert  with any third  person,  for the  purpose  of  acquiring,  holding,  or
disposing of Voting Securities.

                                       28


     8.6 Restrictions on Transfer of Voting Securities.

          (a)  The Purchaser shall not, directly or indirectly, sell or Transfer
               any Voting  Securities for a period of one year  commencing  with
               the Closing Date.

          (b)  Subject to Section 8.6(a),  the Purchaser shall not,  directly or
               indirectly, sell or Transfer any Voting Securities, except

               (i)  to the  Company  or any  person  or  group  approved  by the
                    Company;

               (ii) to an Affiliate of the Purchaser,  as long as such Affiliate
                    agrees to hold such  Voting  Securities  subject  to all the
                    provisions of this  Agreement,  including  this Section 8.6,
                    and  agrees  to  Transfer  such  Voting  Securities  to  the
                    Purchaser or another Affiliate of the Purchaser if it ceases
                    to be an Affiliate of the Purchaser;

               (iii)pursuant to Rule 144 under the  Securities  Act (but only to
                    the extent the sale or Transfer of Voting  Securities at any
                    time  is  in  compliance  with  the  volume  limitations  of
                    paragraph (e) thereunder);

               (iv) pursuant to an effective  registration  statement  under the
                    Securities Act;

               (v)  subject to the Company's right of first refusal as set forth
                    in  Section  9.1  hereof,   in  transactions  not  otherwise
                    described   in  this   Section   9.1(b)   as  long  as  such
                    transactions do not, directly or indirectly, individually or
                    in the  aggregate,  result,  to the  best  knowledge  of the
                    Purchaser, after reasonable inquiry, in any single person or
                    group   owning  or  having  the  right  to  acquire   Voting
                    Securities representing 5% or more of the Total Voting Power
                    of the Company then in effect;

               (vi) pursuant to a bona fide pledge of such Voting  Securities to
                    an institutional lender to secure a loan, guarantee or other
                    financial support,  provided that such lender agrees to hold
                    such Voting  Securities  subject to all  provisions  of this
                    Agreement and any sale or disposition by such lender of such
                    pledged   Voting   Securities   shall  be   subject  to  the
                    limitations of this Section 8.6; or

               (vii)pursuant to a pro rata dividend to the  stockholders  of the
                    Purchaser.

     (c)  Notwithstanding Section 8.6(a), Purchaser may, directly or indirectly,
          sell or Transfer any Voting Securities:

          (i)  in response  to (A) an offer to purchase or exchange  for cash or
               other consideration any Voting Securities (I) which is made by or

                                       29

               on behalf of the Company, or (II) which is made by another person
               or group and is either  recommended  to the  shareholders  of the
               Company by the Board of  Directors or not opposed by the Board of
               Directors of the Company  within the time such Board is required,
               pursuant to  regulations  under the  Exchange  Act, to advise the
               Company's shareholders of such Board's position on such offer, or
               (III)  in the  case of a merger  or  other  business  combination
               transaction,  which has been approved by the  shareholders of the
               Company  (including  approval  without a meeting  pursuant to the
               short-form  merger  provisions  of the  North  Carolina  Business
               Corporation  Act) in a manner so as to be legally  binding on all
               shareholders  of the Company and so as to require the disposition
               by such  shareholders  of their shares pursuant to such merger or
               other business  combination  transaction  (without regard to this
               Agreement)  or (B)  subject  to the  Company's  rights  of  first
               refusal  as set forth in  Section  9.1,  any other  offer made by
               another person or group to purchase or exchange for cash or other
               consideration any Voting  Securities which, if successful,  would
               result  in such  person or group  owning  or having  the right to
               acquire  Voting  Securities  representing  more  than 50 % of the
               Total Voting Power of the Company then in effect;

          (ii) in the event of a merger or consolidation in which the holders of
               Voting   Securities  of  the  Company  prior  to  the  merger  or
               consolidation cease to hold at least 51% of the voting securities
               of the surviving entity; or

          (iii) pursuant to a plan of liquidation of the Company.

     Any shares  permitted to be sold  hereunder  shall be free and clear of the
restrictions contained in this Agreement.

     8.7 Non-Disclosure.

          (a)  During the  duration of this  Agreement  and for a period of five
               (5) years  thereafter,  neither  party  shall  disclose  to third
               parties,  or use  for its  benefit,  in  whole  or in  part,  any
               Proprietary  Information received from other party, except to the
               extent  required to comply with the Food,  Drug and  Cosmetic Act
               (21 U.S.C.  ss.ss.  301 et seq.) and the regulations  promulgated
               thereunder  and all  foreign  equivalents  thereof or other laws.
               Each party shall take all  reasonable  steps to minimize the risk
               of  disclosure of  Proprietary  Information,  including,  without
               limitation:

               (i)  ensuring that only its employees  whose duties  require them
                    to possess such information have access thereto; and

                                       30


               (ii) exercising at least the same degree of care that it uses for
                    its own Proprietary Information.

          (b)  Duties Upon Termination. Except as otherwise permitted under this
               Agreement,  upon request by the disclosing party after expiration
               or  termination of this  Agreement,  the other party shall either
               return all of such  disclosing  party's  Proprietary  Information
               (including data, memoranda, drawings and other writings and tapes
               and all copies thereof) received or prepared by it or destroy the
               same,  and in  any  event  shall  make  no  further  use of  such
               Proprietary  Information  at any  time  provided,  however,  that
               counsel  for  the  receiving  party  may  keep  one  copy  of the
               Proprietary   Information  for  purposes  of   ascertaining   the
               receiving party's obligations pursuant to this Section 8.7.

          (c)  Use of  Proprietary  Information.  During  the  duration  of this
               Agreement and for a period of five (5) years thereafter,  neither
               party shall use the other party's Proprietary Information for any
               purposes,  except to perform  its  obligations  hereunder.  In no
               event shall the Purchaser  use any  Proprietary  Information  for
               commercial   purposes  subsequent  to  the  termination  of  this
               Agreement.

          (d)  Injunctive  Relief.  Each party acknowledges that the other party
               would not have an adequate remedy at law for breach of any of the
               covenants  contained in this  Section 8.7 and hereby  consents to
               the  enforcement of same by the other party by means of temporary
               or permanent  injunction issued by any court having  jurisdiction
               thereof and further agrees that the other party shall be entitled
               to assert any claim it may have for  damages  resulting  from the
               breach of such  covenants  in addition to seeking  injunctive  or
               other  relief.  The  provisions  of this  Agreement  relating  to
               Proprietary  Information  shall  supercede  any prior  agreements
               relating to Proprietary Information between the Purchaser and the
               Company.

     8.8  Company  Right  of  Repurchase.  If at any time  there is a Change  in
Control of the Purchaser  involving another entity having any operations related
to rapid coagulation  monitoring systems,  then the Company shall have the right
to purchase  all,  but not a part of, the Voting  Securities  then  Beneficially
Owned by the Purchaser and its Subsidiaries  upon or prior to the effective date
of the Change in Control of the Purchaser.  The purchase price per share of such
Voting  Securities  shall  be the  Average  Market  Price  as of the date of the
Company's exercise of its right to repurchase.

     8.9  Acquisition  of Stock.  The Purchaser  shall advise  management of the
Company as to the  Purchaser's  acquisition of any  additional  shares of Voting
Securities,  or rights thereto, in writing within 10 calendar days following any
such acquisition. All of the Purchaser's purchases of Voting Securities shall be
in compliance  with  applicable  laws and regulations and the provisions of this
Agreement.

                                       31


     Section 9. Company Right of First Refusal

     Until the  termination  of this  Agreement in accordance  with Section 11.1
hereof or of the particular covenant:

     9.1 Right of First Refusal.  Prior to making any sale or Transfer of Voting
Securities of the Company  pursuant to Section  8.6(a)(v),  the Purchaser  shall
give the  Company the  opportunity  to purchase  such Voting  Securities  in the
following manner:

          (a)  The Purchaser  shall give notice (the  "Transfer  Notice") to the
               Company in writing of such intention  specifying the  approximate
               number of the proposed  purchasers or transferees,  the amount of
               Voting  Securities  proposed  to  be  sold  or  transferred,  the
               proposed price per share therefor (the "Transfer  Price") and the
               other material  terms upon which such  disposition is proposed to
               be made.

          (b)  The Company shall have the right,  exercisable  by written notice
               given  by the  Company  to the  Purchaser  within  30 days  after
               receipt of such Transfer Notice,  to purchase all but not part of
               the Voting Securities  specified in such Transfer Notice for cash
               per share equal to the Transfer Price.

          (c)  If the Company  exercises its right of first  refusal  hereunder,
               the closing of the purchase of the Voting Securities with respect
               to which such right has been exercised shall take place within 60
               calendar days after the Company receives notice,  which period of
               time shall be extended if  necessary  in order to comply with any
               applicable  laws and  regulations.  Upon exercise of its right of
               first  refusal,  the Company and the  Purchaser  shall be legally
               obligated to  consummate  the purchase  contemplated  thereby and
               shall use their best efforts to secure any approvals  required in
               connection therewith.

          (d)  If the  Company  does not  exercise  its  right of first  refusal
               hereunder  within  the  time  specified  for such  exercise,  the
               Purchaser  shall be free,  during the period of 90 calendar  days
               following the  expiration of such time for exercise,  to sell the
               Voting  Securities  specified in such  Transfer  Notice and if no
               sale occurs within such time period,  the Voting Securities shall
               again be subject  to the  provisions  of this  Section  9.1.  The
               Purchaser's  transferee shall acquire such Voting Securities free
               from  any of the  provisions  of this  Agreement;  however,  such
               Voting  Securities shall be subject to any  restrictions  imposed
               under applicable securities laws.

          (e)  Notwithstanding  anything  to  the  contrary  contained  in  this
               Section 9.1, if Purchaser  intends to sell or Transfer any Voting
               Securities of the Company pursuant to Section 8.6(a)(v), and such
               proposed  sale  or  Transfer  is  to an  institutional  purchaser
               approved  by the Company at or above the  Average  Market  Price,
               then the Company must exercise its right of first refusal,  if at
               all,  within ten (10)  business  days of receipt of the  Transfer

                                       32

               Notice,  and if not, the proposed  Transfer  shall  thereafter be
               subject to the provisions of subparagraph 9.1 (d) above.

     9.2  Tender  Offer  Sale.  Prior to making any sale or  exchange  of Voting
Securities pursuant to Section  8.6(c)(i)(B) in response to a tender or exchange
offer,  the Purchaser  shall give the Company the  opportunity  to purchase such
Voting Securities in the following manner:

          (a)  The  Purchaser  shall give  notice (the  "Tender  Notice") to the
               Company in writing of such  intention  no later than 10  calendar
               days prior to the latest time by which Voting  Securities must be
               tendered  in order to be  accepted  pursuant  to such offer or to
               qualify for any  proration  applicable to such offer (the "Tender
               Date"), specifying the amount of Voting Securities proposed to be
               tendered.  For purposes hereof, a tender offer to purchase Voting
               Securities  shall be deemed to be an offer at the price specified
               therein, without regard to any provisions thereof with respect to
               proration or conditions  to the offeror's  obligation to purchase
               (assuming such conditions are not impossible of performance  when
               the offer is made,  without giving effect to the Company's  right
               of first refusal).

          (b)  If the Tender Notice is given,  the Company shall have the right,
               exercisable  by  giving  notice  to the  Purchaser  at least  two
               business  days prior to the Tender Date,  to purchase all but not
               part of the Voting Securities  specified in the Tender Notice for
               cash. If the Company  exercises such right by giving such notice,
               the closing of the purchase of such Voting  Securities shall take
               place not later than one  business  day prior to the Tender Date;
               provided,  however,  that if the purchase price  specified in the
               tender offer  includes any property other than cash, the value of
               any  property  included  in the  purchase  price shall be jointly
               determined  by a nationally  recognized  investment  banking firm
               selected  by each party or, in the event such firms are unable to
               agree, a third nationally  recognized  investment banking firm to
               be selected by such two firms.

          (c)  The   parties   shall  use  their  best   efforts  to  cause  any
               determination  of the  value of any  securities  included  in the
               purchase  price to be made within three  business  days after the
               date of delivery of the Tender  Notice.  If the firms selected by
               the  Purchaser and the Company are unable to agree upon the value
               of any such securities  within such three-day  period,  the firms
               shall promptly select a third firm whose  determination  shall be
               made promptly and shall be conclusive.

          (d)  The   parties   shall  use  their  best   efforts  to  cause  any
               determination  of the value of property other than  securities to
               be made within four  business  days after the date of delivery of
               the Tender Notice. If the firms selected by the Purchaser and the
               Company  are unable to agree upon a value  within  such  four-day
               period,  the  firms  shall  promptly  select a third  firm  whose
               determination shall be made promptly and shall be conclusive.

                                       33

          (e)  The  purchase  price to be paid by the  Company  pursuant to this
               Section 9.2 shall be (x) if such tender offer is consummated, the
               purchase  price that the Purchaser  would have received if it had
               tendered the Voting  Securities  purchased by the Company and all
               such Voting  Securities  had been purchased in such tender offer,
               including any  increases in the price paid by the tender  offeror
               after  exercise  by the  Company  of its  right of first  refusal
               hereunder,  or (y) if such tender offer is not  consummated,  the
               highest bona fide price offered  pursuant  thereto,  in each case
               with  property,  if any,  to be valued as  aforesaid.  Each party
               shall bear the cost of its own  investment  banking  firm and the
               parties   shall  share  the  cost  of  any  third  firm  selected
               hereunder.

          (f)  If the Company does not exercise such right by giving such notice
               or fails to complete the purchase,  then the  Purchaser  shall be
               free to accept the tender  offer with respect to which the Tender
               Notice was given.

          (g)  If the Company  does not  purchase  the shares,  the Company will
               provide such  assurance as the tender  offeror  shall  reasonably
               request to provide the tender offeror with  certificates  for the
               Purchaser's shares without legends referring to this Agreement.

     9.3 Assignment of Rights.  In the event that the Company elects to exercise
a right of first refusal under this Section 9, the Company may specify, prior to
closing such purchase and upon not less than three business days prior notice to
the Purchaser,  another person as its designee to purchase the Voting Securities
to which such notice relates.  If the Company shall designate  another person as
the purchaser  pursuant to this Section 9, the giving of notice of acceptance of
the right of first  refusal by the Company  shall  constitute a legally  binding
obligation of the Company to complete such purchase if such designee  shall fail
to do so.

     Section 10. Definitions

     "Affiliate"  of a Person has the  meaning set forth in Rule 12b-2 under the
     Exchange Act.

     "Agreement" has the meaning set forth in the recitals hereof.

     "Average Market Price" of any security at any date shall be the average
of the closing  prices for a share or other single unit of such  security on the
30  consecutive  trading days ending on the trading date last preceding the date
of determination of such price on the principal national  securities exchange on
which  such  security  is  listed,  or, if such  security  is not  listed on any
national  securities  exchange,  the average of the closing  sales  prices for a
share of such  security on NASDAQ or, if such closing  sales prices shall not be
reported on NASDAQ,  the  average of the mean  between the closing bid and asked
prices of a share of such  security  in such case as reported by The Wall Street
Journal,  or, if such  prices  shall not be so  reported,  as the same  shall be
reported by the National Quotation Bureau Incorporated,  or, in all other cases,
the value as determined by a single  nationally  recognized  investment  banking
firm jointly  selected by the Company and the Purchaser.  For this purpose,  the
parties shall use their best efforts to cause any  determination of the value to
be made  within  10  business  days  after  the date on which the value is to be

                                       34


measured.  The  determination  by the  investment  banking firm  selected in the
manner set forth above shall be conclusive.

     "Beneficially  Own" with respect to any securities means having "beneficial
ownership" of such  securities (as  determined  pursuant to Rule 13d-3 under the
Exchange Act, as in effect on the date hereof,  without limitation by the 60-day
provision in paragraph (d)(1)(i) thereof).  The terms "Beneficial Ownership" and
"Beneficial Owner" have correlative meanings.

     "Change in Control" means the occurrence of any of the following events:

          (a)  the direct or indirect  purchase or  acquisition by any Person or
               13D Group (other than an Excluded Person) of Beneficial Ownership
               of Voting  Securities  or Common  Securities  of the  Company if,
               after giving effect to such acquisition, such Person or 13D Group
               would  Beneficially  Own Voting  Securities or Common  Securities
               representing  an  Equity  Percentage  of 30% or  more  on a fully
               diluted basis;

          (b)  the  consummation by the Company or any of its  Subsidiaries of a
               merger,  consolidation  or other  business  combination  with any
               Person (other than an Excluded Person) that requires the approval
               of the holders of the Company's  capital stock,  whether for such
               transaction or the issuance of securities in such transaction, if
               immediately after giving effect to such transaction,  the Persons
               who  Beneficially  Owned Voting  Securities or Common  Securities
               immediately  prior to such  transaction  Beneficially  Own in the
               aggregate  Voting  Securities  or Common  Securities  (or  voting
               securities or common securities in the case of a surviving entity
               other  than  the  Company)   representing   a  Voting   Ownership
               Percentage or a Total  Ownership  Percentage  (or voting power or
               common  equity  ownership of common  securities  in the case of a
               surviving entity other than the Company) on a fully diluted basis
               of  less  than  50%  immediately  after  giving  effect  to  such
               transaction;

          (c)  the consummation by the Company of a plan of complete liquidation
               or dissolution of the Company;

          (d)  the sale of all or  substantially  all of the Company's assets to
               any Person (other than an Excluded Person); or

          (e)  the sale or transfer of all or substantially all of the Company's
               rights  related to the  manufacture  and sale of  products in the
               Company's Routine Product or Specialty Product division,  as such
               terms are defined in the  Distribution  Agreement,  to any Person
               (other than an Excluded Person).

     "Change in Control of the Purchaser" shall mean any of the following: (i) a
merger or consolidation to which the Purchaser is a party if the shareholders of
the  Purchaser  immediately  prior  to the  effective  date  of such  merger  or
consolidation have Beneficial  Ownership of voting securities  representing less
than 50 % of the Total Voting Power of the surviving  corporation following such
merger or consolidation;  (ii) an acquisition by any person,  entity or group of

                                       35


direct or indirect  Beneficial  Ownership of voting  securities of the Purchaser
representing 40 % or more of the Total Voting Power of the Purchaser then issued
and  outstanding;  (iii)  a sale  of all or  substantially  all  the  assets  of
Purchaser;  (iv) a liquidation of Purchaser;  or (v) a change in the composition
of the Board of  Directors  of the  Purchaser  such that during any  consecutive
24-month period, directors who are members of the Board at the beginning of such
24-month period, or their successors who were elected,  nominated or recommended
by at least a majority of the Board of Directors as  constituted  at the time of
their  appointment to the Board,  cease to constitute at least a majority of the
Board of Directors.

     "Change in Control  Transaction" means a transaction which, if consummated,
would result in a Change in Control.

     "Change in Control  Price Per Share" has the  meaning  set forth in
Section 7.4.

     "Closing" has the meaning set forth in Section 2.1.

     "Closing Date" has the meaning set forth in Section 2.1.

     "Common Stock" has the meaning set forth in Section 1.1.

     "Common  Securities"  means the Common Stock,  the Preferred  Stock and any
other securities of the Company  (excluding  non-voting  securities  (other than
capital  stock)  issued to  directors,  officers or  employees of the Company as
compensation)  to the extent to which such  securities  by the terms thereof (i)
are not  effectively  limited in amount as to dividends or amounts  payable upon
liquidation  of the Company or (ii) are  otherwise a  substantial  equivalent of
Common  Stock  as to  dividends  or  upon  liquidation  of the  Company  or upon
consummation  of a  merger  or other  extraordinary  transaction  in  which  the
outstanding shares of Common Stock participate.

     "Company" has the meaning set forth in the recitals hereof.

     "Continuously   Effective,"  with  respect  to  a  specified   registration
statement,  shall mean that such  registration  statement  shall not cease to be
effective and available for transfers of Registrable  Securities  thereunder for
longer  than  either  (i) any ten (10)  consecutive  business  days,  or (ii) an
aggregate  of fifteen  (15)  business  days during the period  specified  in the
relevant provision of this Agreement.

     "Current  Facility"  means the equipment and space used in the operation of
the business  prior to the effective  date hereof,  including the  approximately
60,000 square feet of building space leased by the Company,  and the surrounding
property  leased,  controlled,  or used by the Company at 5301 Departure  Drive,
Raleigh, North Carolina, 27616.

     "Demand Registration" shall have the meaning set forth in Section 7.6(a).

     "Distribution Agreement" has the meaning set forth in Section 7.4.

     "Environment" shall mean soil, surface waters,  groundwaters,  land, stream
sediments,  surface  or  subsurface  strata,  indoor  or  outdoor  air,  and any
environmental medium.

                                       36


     "Environmental  Condition"  shall mean any  condition  with  respect to the
Environment on or off the Facilities, whether or not yet discovered, which could
or does result in any damage,  loss, cost,  expense,  claim,  demand,  order, or
liability  to or  against  the  Company  or the  Purchaser  by any  third  party
(including,  without limitation, any government authority),  including,  without
limitation, any condition resulting from the operation of the Company's business
and/or the operation of the business of any other  property owner or operator in
the  vicinity  of the  Facilities  and/or any  activity  or  operation  formerly
conducted by any person or entity on or off the Facilities.

     "Environmental Law" shall mean any statute,  rule,  regulation,  ordinance,
decree,  or order of any  Governmental  Entity or court,  including  common law,
relating to (i) the control of any potential pollutant, pathogen, or waste; (ii)
protection of the  Environment;  or (iii)  protection of public or  occupational
health and safety,  whether any of the foregoing are enacted or  promulgated  at
the federal,  state,  or local level,  including  but not limited to, the terms,
conditions,  restrictions,  and obligations imposed by any Environmental  Permit
(as defined  below).  The term  "Environmental  Law" shall  include,  but not be
limited to, the following statutes and regulations promulgated  thereunder:  the
Clean Air Act, 42 U.S.C.  ss. 7401 et seq.,  the Clean Water Act, 33 U.S.C.  ss.
1251 et seq., the Superfund  Amendments and  Reauthorization  Act, 42 U.S.C. ss.
1101 et seq.("SARA"),  the Toxic  Substances  Control Act, 15 U.S.C. ss. 2601 et
seq., the Safe Drinking Water Act, 42 U.S.C. ss. 300f et seq., the Comprehensive
Environmental  Response,  Compensation,  and Liability Act  ("CERCLA"),  and any
state, county, or local statues, regulations, or ordinances similar thereto.

     "Environmental Permits" has the meaning set forth in Section 3.9(b).

     "Equity Percentage" means, with respect to any Common Securities calculated
at any particular point in time, the ratio, expressed as a percentage of (a) the
total number of shares of Common Stock included in, or issuable upon  conversion
of (whether or not then  convertible),  or otherwise  constituting  the economic
equivalent  of, such Common  Securities  over (b) the total  number of shares of
Common Stock then  outstanding and the number of shares of Common Stock issuable
upon conversion of (whether or not then convertible),  or otherwise constituting
the economic equivalent of, all outstanding Common Securities.

     "Exchange Act" has the meaning set forth in Section 3.5.

     "Excluded Person" shall mean (i) any member of the Purchaser Group,
(ii) any  wholly  owned  Subsidiary  of the  Company,  or (iii) any  underwriter
temporarily  holding Common  Securities in connection  with a public offering of
such securities.

     "Facilities"  means either the Current Facility or the New Facility or both
of  them.

     "Governmental  Entity" means any government or any agency,  bureau,  board,
commission,  court,  department,  political  subdivision,   tribunal,  or  other
instrumentality  of any government  (including any regulatory or  administrative
agency), whether federal, state or local, domestic or foreign.

     "Group"  shall have the  meaning  comprehended  by Section  13(d)(3) of the
Exchange Act and the rules and regulations promulgated thereunder.

                                       37

     "Inclusion Notice" has the meaning set forth in Section 7.6(a).

     "Indemnified Party" has the meaning set forth in Section 7.6(f).

     "Indemnifying Party" has the meaning set forth in Section 7.6(f).

     "Intellectual  Property"  means any and all,  whether  domestic or foreign,
patents,  patent  applications,   patent  rights,  trade  secrets,  confidential
business information,  formulae, processes,  copyrights, software methodologies,
claims of infringement  against third parties,  licenses (other than software or
similar licenses  commercially  available),  permits,  license rights,  contract
rights with employees,  consultants  and third parties,  joint venture rights or
rights  under any  contract or  agreement  involving  the license or transfer of
technology  (whether  to or from the  Company  or its  Subsidiaries  with  third
parties), rights of priority, goodwill,  Trademarks,  trademark rights, works of
authorships,  inventions  and  discoveries,  and  other  such  rights  generally
classified  as  intangible,  intellectual  property  assets in  accordance  with
generally accepted accounting  principles;  provided that when used with respect
to the Company or its  Subsidiaries,  the term refers to  Intellectual  Property
used or held for use in or required for use in  connection  with the business of
the Company or its Subsidiaries as now operated or as proposed to be operated by
the Company or its Subsidiaries in the future.

     "Intellectual  Property  Agreements" means all agreements,  arrangements or
understandings  (whether  written or oral)  pursuant to which the Company or any
Subsidiary has either purchased,  sold, licensed,  secured or disposed of rights
in  Intellectual  Property from or to another  Person or agreed to do any of the
foregoing (other than licenses to commercially available  off-the-shelf computer
software  acquired  or  entered  into by the  Company or any  Subsidiary  in the
ordinary course of business).

     "Material  Adverse  Effect"  means  any  material  adverse  effect  on  the
financial condition,  business or operations of the Company and its Subsidiaries
taken as a whole.

     "NASD" has the meaning set forth in Section 3.6.

     "NASDAQ" has the meaning set forth in Section 7.8.

     "New Facility" means the equipment and space to which the Company has moved
the operation of the business,  the approximately 60,000 square feet of building
space leased by the Company, and the surrounding property leased,  controlled or
used by the Company at 9401 Globe Center, Morrisville, North Carolina 27560.

"Order" means any judgment,  decree,  order, writ, award,  ruling,  stipulation,
injunction or  determination  of an  arbitrator  or court or other  Governmental
Entity.

     "Original  Shares" means the 600,000  shares of common stock of the Company
previously  acquired  by  Chiron  Diagnostics  Corporation  (predecessor  to the
Company) as a result of the Company's exchange offer in 1998.

     "Participating Holders" has the meaning set forth in Section 7.6(a).

                                       38


     "Permit"   shall  mean  any  permit,   license,   approval,   consent,   or
authorization issued by a federal,  state, or local Governmental Entity pursuant
to  Environmental  Law,  and any term,  condition,  restriction,  or  obligation
imposed thereby.

     "Person"  means  any   individual,   corporation,   company,   association,
partnership,  joint venture,  limited liability company, trust or unincorporated
organization, group (within the meaning of Rule 13d-5 under the Exchange Act) or
a government or any agency or political  subdivision  thereof (whether  foreign,
federal, state, local or otherwise).

     "Pre-Approved Persons" has the meaning set forth in Section 7.3(b).

     "Preferred Stock" has the meaning set forth in Section 3.2.

     "Pro Rata Share" has the meaning set forth in Section 7.9.

     "Proposal" means any inquiry, indication of interest, proposal or offer
made to the Company or publicly  disclosed by any Person  relating to any Change
in Control Transaction.

     "Proprietary  Information"  means:  all  financial  information,  marketing
information,  sales information,  customer information, raw materials, know-how,
drawings,  compositions,  manufacturing  and  other  specifications,  analytical
procedures, flow sheets, reports, market studies,  preclinical and clinical test
results,  FDA and other  regulatory  submissions,  software  and other  medical,
research,   technical,   and  marketing  information   disclosed,   directly  or
indirectly,  by  either  party  or any of its  Affiliates  to the  other  party,
retroactively  to  December  17,  1997,  in  writing,   marked   "Confidential",
"Proprietary"  or the like,  or, if  transmitted  orally  or by  observation  of
equipment or other material,  confirmed by a writing so marked within sixty (60)
days of its disclosure,  or which by its nature is information normally intended
to be held in confidence,  unless the same:  (a) is or becomes public  knowledge
through no fault of the receiving party; (b) is legally in the possession of the
receiving party prior to receipt from the disclosing  party; (c) is subsequently
and lawfully received from a third party without its breach of any nondisclosure
obligation;  (d) is independently  developed by employees of the receiving party
who have had no access to the Proprietary  Information of the disclosing  party;
or (e) is required to be disclosed by order of a court or administrative agency,
provided that in such event the party that is subject to the required disclosure
furnish the other party with adequate  notice.  Notwithstanding  the immediately
preceding  sentence,  the  Company  agrees  that  all new  materials  and  other
information which the Purchaser or its predecessor provided to the Company prior
to December 17, 1997, shall be treated as Proprietary Information.

     "Purchase Price Per Share" has the meaning set forth in Section 1.2.

     "Purchaser" has the meaning set forth in the recitals hereof.

     "Purchaser Group" shall mean (a) the Purchaser, (b) any Subsidiary of
the  Purchaser,  (c) any Affiliate of the Purchaser  controlled by the Purchaser
such that the Purchaser has the legal or contractual power  (including,  without
limitation,  through  negative  control or through the Purchaser's  designees or
representatives  on the  board  of  directors  or other  governing  body of such
Affiliate or under the articles of incorporation or other constituent  documents
of such Affiliate or as a result of the voting rights of any securities or other

                                       39


instruments issued by such Affiliate) to cause such Affiliate to comply with the
terms of this  Agreement  applicable to the  Purchaser,  and (d) any Person with
whom the Purchaser or any Person included in the foregoing clauses (b) or (c) is
part of a 13D Group.

     "Purchaser Nominee" has the meaning set forth in Section 7.3(a).

     "Register,"  "registered," and "registration" shall refer to a registration
effected by preparing and filing a registration statement or similar document in
compliance  with the Securities  Act, and the declaration or ordering by the SEC
of effectiveness of such registration statement or document.

     "Registrable Securities" shall mean (A) the Shares, (B) the Original Shares
and (C) any shares of Common Stock issued as (or issuable upon the conversion of
any  warrant,  right or other  security  which is issued as) a dividend or other
distribution  with respect to or in replacement of the Common Stock described in
clauses (A), (B) and (C) above.  In the event that the Common Stock is converted
into any other security pursuant to any merger, consolidation, recapitalization,
liquidation or other similar transaction,  and if any securities are distributed
in respect of any Registrable  Securities,  then all of such securities shall be
considered Registrable Securities for purposes of this Agreement.

     "Registration Expenses" shall have the meaning set forth in
Section 7.6(e).

     "Regulatory Approvals" means any and all certificates,  permits,  licenses,
franchises,  concessions,  grants, consents,  approvals, orders,  registrations,
authorizations, waivers, variances or clearance from a Governmental Entity.

     "Release" shall mean any releasing,  spilling,  leaking,  pumping, pouring,
emitting, emptying,  discharging,  injecting,  escaping, leaching, disposing, or
dumping into the Environment.

     "Securities Act" has the meaning set forth in Section 2.2.

     "SEC" has the meaning set forth in Section 3.5.

     "SEC Reports"  means (i) the  Company's  Annual Report on Form 10-K for the
fiscal years ended  December,  2000,  1999 and 1998; and (ii) each  registration
statement,  report  on Form  8-K and  Form  8-A,  proxy  statement,  information
statement or other document,  report or statement filed by the Company or any of
its  Subsidiaries  with the SEC since  January 1, 1998, in each case in the form
(including financial statements, schedules, exhibits and any amendments thereto)
filed with the SEC.

     "Shares" has the meaning set forth in Section 1.2.

     "Subsidiary"  means,  as to any  Person,  any other  Person more than fifty
percent (50%) of the shares of the voting  securities or other voting  interests
of which are owned or  controlled,  or the  ability to select or elect more than
fifty percent (50%) of the  directors or similar  managers is held,  directly or
indirectly,  by such first Person or one or more of its  Subsidiaries or by such
first Person and one or more of its Subsidiaries.  A Subsidiary that is directly

                                       40


or indirectly  wholly-owned  by another Person except for directors'  qualifying
shares shall be deemed wholly-owned for purposes of this Agreement.

     "Substances"  means any pollutant,  toxic substance,  hazardous  substance,
hazardous material,  pathogen,  radioactive  substance,  solid waste,  hazardous
waste,  biological  waste,  petroleum,  or petroleum  substance as defined in or
regulated  pursuant  to any  Environmental  Law  enacted on or prior to the date
hereof.

     "13D Group" shall mean any group of Persons who, with respect to those
acquiring,  holding,  voting or disposing of Voting Securities  would,  assuming
ownership of the requisite  percentage  thereof, be required under Section 13(d)
of the Exchange Act and the rules and regulations thereunder to file a statement
on  Schedule  13D with the SEC as a  "person"  within  the  meaning  of  Section
13(d)(3) of the Exchange Act, or who would be considered a "person" for purposes
of Section 13(g)(3) of the Exchange Act. "13D Group" when used with reference to
standards  or tests that are based on  securities  other than Voting  Securities
shall have the foregoing  meaning  except that the words "Voting  Securities" in
the second line of the  definition  of "13D Group",  in the case of standards or
tests based on  "securities  of the  Company",  shall be replaced with the words
"securities of the Company".

     "Tender Notice" has the meaning set forth in Section 9.2(a).

     "Tender Date" has the meaning set forth in Section 9.2(a).

     "Threat of Release"  shall mean a substantial  likelihood of a Release that
requires action to prevent or mitigate damage to the Environment that may result
from such Release.

     "Total Ownership  Percentage"  means, with respect to any Person calculated
at a particular point in time, the ratio, expressed as a percentage,  of (a) the
total  number of shares of Common  Stock  Beneficially  Owned by such Person and
issuable  upon  conversion  of (whether or not then  convertible),  or otherwise
constituting  the economic  equivalent  of, all Common  Securities  Beneficially
Owned by such  Person,  over (b) the total number of shares of Common Stock then
outstanding  and the number of shares of Common Stock  issuable upon  conversion
(whether or not then  convertible)  of, or otherwise  constituting  the economic
equivalent of, all outstanding Common Securities.

     "Total  Voting  Power" means the total number of votes which may be cast in
the  election of  directors  of a Person at any meeting of  shareholders  of the
Person if all  securities  entitled to vote in the  election of directors of the
Person were present and voted at such meeting (other than votes that may be cast
only upon the happening of a contingency) plus, without duplication of any Votes
otherwise  taken into account,  the number of Votes  attributable  to any voting
securities issued by the Person since the most recent meeting of shareholders of
the Person.

     "Trademark" shall mean any word, name, symbol or device or any
combination thereof, whether or not registered, used to identify and distinguish
a Person's goods or services, including unique products, from those manufactured
or sold by others and to indicate the source of the goods or  services,  even if
that source is unknown.

                                       41


     "Transfer" shall mean and include the act of selling, giving, transferring,
creating a trust  (voting or  otherwise),  assigning or  otherwise  disposing of
(other than pledging,  hypothecating or otherwise transferring as security) (and
correlative words shall have correlative meanings);  provided, however, that any
transfer or other  disposition upon foreclosure or other exercise of remedies of
a secured  creditor after an event of default under or with respect to a pledge,
hypothecation or other transfer as security shall constitute a "Transfer."

     "Transfer Notice" has the meaning set forth in Section 9.1(a).

     "Transfer Price" has the meaning set forth in Section 9.1(a).

     "Underwriters'  Representative" shall mean the managing underwriter, or, in
the case of a co-managed  underwriting,  the managing underwriter  designated as
the Underwriters' Representative by the co-managers.

     "Votes" shall mean, at any time, with respect to any Voting Securities, the
total number of votes that would be entitled to be cast by the holders of
such Voting Securities  generally (by the terms of such Voting  Securities,  the
Articles of  Incorporation  or any certificate of  designations  for such Voting
Securities)  in a meeting  for the  election  of  Directors  held at such  time,
including  the votes  that  would be able to be cast by holders of shares of any
preferred stock.

     "Voting Ownership  Percentage" shall mean, calculated at a particular point
in time,  the Voting Power  represented  by the Voting  Securities  Beneficially
Owned by the Person whose Voting Ownership Percentage is being determined.

     "Voting  Power" shall mean,  calculated at a particular  point in time, the
ratio,  expressed as a percentage,  of (a) the Votes  represented  by the Voting
Securities  with  respect to which the Voting Power is being  determined  to (b)
Total Voting Power of the Company.

     "Voting  Securities"  means the shares of Common Stock, the Preferred Stock
and any other  securities  of the  Company  entitled to vote  generally  for the
election of directors,  and any  securities  (other than employee stock options)
which  are  convertible   into,  or  exercisable  or  exchangeable  for,  Voting
Securities.

     "Warrants"  shall mean those  certain  warrants to  purchase  shares of the
Common  Stock  issued  pursuant  to that  certain  Preferred  Stock and  Warrant
Purchase Agreement dated as of February 24, 2000.

     Section 11. Miscellaneous

     11.1 Termination of Agreement.

          (a)  The Company may  terminate  its  obligation to perform or observe
               any of its  covenants and  agreements  hereunder if the Purchaser
               violates any of the  covenants  or  agreements  of the  Purchaser
               under  this  Agreement  or the  Distribution  Agreement,  and the
               Purchaser may terminate its obligations to perform or observe any
               of its covenants and agreements hereunder if the Company violates

                                       42


               or fails to perform any of the  covenants  or  agreements  of the
               Company under this Agreement; provided, however, that the Company
               or the  Purchaser,  as the case may be, may not  terminate any of
               its  obligations  under this Agreement  pursuant to this sentence
               unless it shall have delivered  written notice of such default to
               the other party and such default shall not have been cured within
               30 calendar days after the delivery of such notice.

          (b)  From and after the termination of this Agreement,  the covenants,
               obligations  and agreements of the parties set forth herein shall
               be of no further  force or effect and the parties  shall be under
               no further obligation with respect thereto.

          (c)  Notwithstanding   the   provisions  of  this  Section  11.1,  the
               respective  obligations  of the Company and the  Purchaser  under
               Sections  7.6  and  8.7  of  this  Agreement  shall  survive  any
               termination of this Agreement.

     11.2 Best  Efforts.  As long as the other party hereto is not in default of
          any material obligation under this Agreement,  each of the Company and
          the Purchaser shall use its best efforts to take all actions  required
          under  any law,  rule or  regulation  adopted  subsequent  to the date
          hereto in order that the  respective  agreements  and covenants of the
          parties  hereto  may be  carried  out on a timely  basis in the manner
          contemplated by this Agreement.

     11.3 Governing Law. This Agreement shall be governed in all respects by the
          laws of the State of North  Carolina as applied to  contracts  entered
          into solely between residents of, and to be performed entirely within,
          such state.

     11.4 Survival.  The  representations  and warranties in Sections 3 and 4 of
          this Agreement shall survive any  investigation  made by the Purchaser
          or the Company and the  Closing,  and shall  expire one year after the
          Closing;  provided that such  representations and warranties shall not
          be  construed  so  as to  constitute  representations  and  warranties
          concerning  circumstances  existing  after the date of this  Agreement
          (except for the representation  made in Section 4.1 hereof which shall
          be deemed to be made by the Purchaser in connection with each purchase
          of shares purchased from the Company pursuant to this Agreement).

     11.5 Successors and Assigns. This Agreement shall be binding upon and shall
          inure to the  benefit  of the  parties  hereto  and  their  respective
          successors  and  assigns.   Except  as  otherwise   provided  in  this
          Agreement,  this  Agreement may not be assigned by a party without the
          prior  written  consent of the other party  except by operation of law
          and  except,  in the case of the  Purchaser,  to an  Affiliate  of the
          Purchaser,  in which case the assignee  shall be subject to all of the
          provisions  of this  Agreement.  The  Purchaser  may not  assign  this
          Agreement to any pledgee of its shares of Common Stock.

     11.6 Entire  Agreement;  Amendment.  This Agreement and the other documents
          delivered pursuant hereto constitute the full and entire understanding
          and  agreement  between the parties with regard to the subject  matter
          hereof  and   thereof  and   supersede   all  prior   agreements   and
          understandings  among  the  parties  relating  to the  subject  matter
          hereof.  No party  shall be liable or bound to any other  party in any

                                       43

          manner  by any  warranties,  representations  or  covenants  except as
          specifically  set forth  herein.  Neither this  Agreement nor any term
          hereof may be amended, waived,  discharged or terminated other than by
          a written  instrument  signed by the party against whom enforcement of
          any such amendment, waiver, discharge or termination is sought.

     11.7 Notices and Dates. Any notice or other  communication given under this
          Agreement  shall be sufficient if in writing and delivered by hand, by
          messenger or by courier,  or transmitted  by facsimile,  to a party at
          its  address  set forth  below (or at such  other  address as shall be
          designated  for such purpose by such party in a written  notice to the
          other party hereto):

                  if to the Company, to it at:

                           Pharmanetics, Inc.
                           9401 Globe Center Drive
                           Suite 140
                           Morrisville, NC  27560
                           Attention:  President
                           Fax: (919) 954-9932

                  with a copy to:

                           Larry E. Robbins, Esq.
                           Wyrick Robbins Yates & Ponton, LLP
                           4101 Lake Boone Trail, Suite 300
                           Raleigh, North Carolina   27607
                           Fax: (919) 781-4865

                  if to Purchaser, to it at:

                           Bayer Corporation
                           63 North Street
                           Medfield, Massachusetts   02052
                           Attention: Senior Vice President and General Manager,
                           Near Patient
                           Testing Segment
                           Fax: (508) 359-3115

                                       44


                  with copies to:

                           Bayer Corporation
                           63 North Street
                           Medfield, Massachusetts   02052
                           Attention: NPT Counsel
                           Fax: (508) 359-3885

                           Marilyn Mooney
                           Fulbright & Jaworski L.L.P.
                           801 Pennsylvania Avenue, N.W.
                           Washington, D.C. 20004-2615
                           Fax: (202) 662-4643


Each such notice or other communication shall for all purposes of this Agreement
be treated  as  effective  or having  been given  when  delivered  if  delivered
personally,  by  messenger  or by  courier,  or,  if  sent  by  facsimile,  upon
confirmation of receipt.

     11.8 Specific  Performance.  The parties hereto  acknowledge and agree that
          irreparable  damage would occur in the event any of the  provisions of
          this  Agreement  were not performed in accordance  with their specific
          terms or were  otherwise  breached  and that such damage  would not be
          compensable in money damages and that it would be extremely  difficult
          or impracticable to measure the resultant  damages.  It is accordingly
          agreed that any party  hereto  shall be entitled to an  injunction  or
          injunctions to prevent breaches of the provisions of the Agreement and
          to enforce  specifically the terms and provisions  hereof, in addition
          to any other remedy to which it may be entitled at law or equity,  and
          such party that is sued for breach of this Agreement  expressly waives
          any defense that a remedy in damages  would be adequate and  expressly
          waives any  requirement in an action for specific  performance for the
          posting of a bond by the party bringing such action.

     11.9 Further  Assurances.  The parties hereto shall do and perform or cause
          to be done and  performed  all such  further acts and things and shall
          execute  and  deliver   all  such  other   agreements,   certificates,
          instruments  or  documents as any other party may  reasonably  request
          from time to time in order to carry out the  intent  and  purposes  of
          this Agreement and the consummation of the  transactions  contemplated
          hereby.  Neither  the  Company  nor the  Purchaser  shall  voluntarily
          undertake any course of action  inconsistent  with satisfaction of the
          requirements  applicable to them set forth in this  Agreement and each
          shall  promptly do all such acts and take all such  measures as may be
          appropriate  to enable  them to  perform as early as  practicable  the
          obligations herein required to be performed by them.

     11.10Counterparts.  This  Agreement  may  be  executed  in  any  number  of
          counterparts,  each of which may be  executed by fewer than all of the
          parties,  each of  which  shall be  enforceable  against  the  parties
          actually executing such counterparts,  and all of which together shall
          constitute one instrument.

                                       45


     11.11Severability.  In the  event  that  any  provision  of this  Agreement
          becomes or is  declared  by a court of  competent  jurisdiction  to be
          illegal,  unenforceable or void, this Agreement shall continue in full
          force  and  effect  without  said  provision;  provided,  that no such
          severability  shall be effective if it materially changes the economic
          impact of this Agreement on any party.

     11.12Captions.  Headings of the various  sections  of this  Agreement  have
          been  inserted  for  convenience  of  reference  only and shall not be
          relied upon in construing this Agreement.  Use of any gender herein to
          refer to any person shall be deemed to comprehend masculine,  feminine
          and neuter unless the context clearly requires otherwise.

     11.13Public  Statements.  The Company and the Purchaser  agree not to issue
          any public  statement  with respect to the  Purchaser's  investment or
          proposed  investment  in the Company or the terms of any  agreement or
          covenant among them without the other party's reasonable prior written
          consent,  except such  disclosures as may be required under applicable
          law or under any applicable  order, rule or regulation or, in the case
          of the Company,  except as necessary to pursue  discussions with other
          strategic Purchasers.

     11.14 Brokers.

          (a)  The Company  has not  engaged,  consented  to or  authorized  any
               broker, finder or intermediary to act on its behalf,  directly or
               indirectly,  as a broker,  finder or  intermediary  in connection
               with the transactions contemplated by this Agreement. The Company
               hereby agrees to indemnify  and hold harmless the Purchaser  from
               and against all fees,  commissions or other payments owing to any
               such person or firm acting on behalf of the Company hereunder.

          (b)  The  Purchaser has not engaged,  consented to or  authorized  any
               broker, finder or intermediary to act on its behalf,  directly or
               indirectly,  as a broker,  finder or  intermediary  in connection
               with  the  transactions   contemplated  by  this  Agreement.  The
               Purchaser  hereby  agrees  to  indemnify  and hold  harmless  the
               Company from and against all fees,  commissions or other payments
               owning  to any  such  person  or firm  acting  on  behalf  of the
               Purchaser hereunder,

          11.15Costs and  Expenses.  Each party  hereto  shall pay its own costs
               and expenses incurred in connection herewith,  including the fees
               of its counsel,  auditors and other  representatives,  whether or
               not the transactions contemplated herein are consummated.

          11.16No Third-Party Rights.  Nothing in this Agreement shall create or
               be deemed  to create  any  rights in any  person or entity  not a
               party to this  Agreement  except for such  rights as may exist by
               virtue of any  contract or other  agreement  existing on the date
               hereof.

          11.17Attorneys' Fees, The prevailing  party in any litigation  between
               the Purchaser and the Company  involving this Agreement  shall be
               entitled  to  recover   from  the  other  party  its   reasonable
               attorneys' fees and costs,

                                       46


          11.18Amendment.  Sections  7, 8, 9,  10 and 11 of that  certain  Stock
               Purchase  Agreement dated August 28, 1998 between  Cardiovascular
               Diagnostics,   Inc.  (predecessor  to  the  Company)  and  Chiron
               Diagnostics Corporation  (predecessor to the Purchaser) is hereby
               amended and  restated  in their  entirety in Sections 7, 8, 9, 10
               and 11,  respectively,  of this Agreement;  provided that Section
               8.6(a)  shall be deemed  satisfied  with  respect to the Original
               Shares.





                     [The next page is the signature page.]


                                       47





IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed
by their respective authorized officers as of the date first above written.

                          PHARMANETICS, INC.



                      By:      /s/ John Funkhouser
                                   John Funkhouser
                                   President


                          BAYER CORPORATION



                      By:      /s/ Frances L. Tuttle
                                   Frances L. Tuttle
                                   Senior Vice President - Near Patient Testing


                                       48