UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                                        _____________

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 1 )*

                           RIGEL PHARMACEUTICALS, INC.

                                (Name of Issuer)

                    COMMON STOCK, $0.001 PAR VALUE PER SHARE

                         (Title of Class of Securities)

                                   766559 10 8

                                 (CUSIP Number)

                                    Copy to:

         Thomas S. Hodge                  David Wilson
         Chief Operating Officer          Heller Ehrman White & McAuliffe, LLP
         Frazier Management, L.L.C.       701 Fifth Avenue, Suite 6100
         Two Union Square                 Seattle, WA  98104
         601 Union Street
         Seattle, WA  98101
         (206) 621-7200                   (206) 447-0900


                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                  APRIL 5, 2004

             (Date of Event which Requires Filing of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following box
..

Note:  Schedules  filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See Rule 13d-7 for other parties
to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).




                                  SCHEDULE 13D



 CUSIP No. 766559 10 8




1 Name of Reporting Persons.
  I.R.S.Identification Nos. of above persons (entities only).

                FRAZIER HEALTHCARE II, L.P.


2 Check the Appropriate Box if a Member of a Group (See Instructions)

                (a)

                (b)



3               SEC Use Only



4               Source of Funds (See Instructions)


                00



5 Check if Disclosure of Legal Proceedings Is Required Pursuant to
  Items 2(d) or 2(e)



6               Citizenship or Place of Organization


                Delaware



  Number of             7      Sole Voting Power
  Shares?
  Beneficially
  Owned by                     0
  Each
  Reporting
  Person
  With



                        8      Shared Voting Power


                               1,405,989


                        9      Sole Dispositive Power


                               0


                        10     Shared Dispositive Power


                               1,405,989


11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                1,405,989


12
     Check if the Aggregate Amount in Row (11) Excludes Certain Shares
     (See Instructions)


13
                Percent of Class Represented by Amount in Row (11)


                7.9%

14
                Type of Reporting Person (See Instructions)
                OO






 CUSIP No. 766559 10 8




1               Name of Reporting Persons.
                I.R.S.Identification Nos. of above persons (entities only).

                FHM II, L.L.C.


2               Check the Appropriate Box if a Member of a Group
                (See Instructions)

                (a)

                (b)



3               SEC Use Only



4               Source of Funds (See Instructions)


                OO



5               Check if Disclosure of Legal Proceedings Is Required
                Pursuant to Items 2(d) or 2(e)



6               Citizenship or Place of Organization


                Delaware



  Number of             7      Sole Voting Power
  Shares?
  Beneficially
  Owned by                     0
  Each
  Reporting
  Person
  With


                        8      Shared Voting Power


                               1,405,989


                        9      Sole Dispositive Power


                               0


                        10     Shared Dispositive Power


                               1,405,989


11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                1,405,989


12
                Check if the Aggregate Amount in Row (11)
                Excludes Certain Shares (See Instructions)


13
                Percent of Class Represented by Amount in Row (11)


                7.9%

14
                Type of Reporting Person (See Instructions)
                OO






 CUSIP No. 766559 10 8




1               Name of Reporting Persons.
                I.R.S.Identification Nos. of above persons (entities only).

                FRAZIER HEALTHCARE IV, L.P.


2               Check the Appropriate Box if a Member of a Group
                (See Instructions)

                (a)

                (b)



3               SEC Use Only



4               Source of Funds (See Instructions)


                WC



5               Check if Disclosure of Legal Proceedings Is Required
                Pursuant to Items 2(d) or 2(e)



6               Citizenship or Place of Organization


                Delaware


  Number of             7      Sole Voting Power
  Shares?
  Beneficially
  Owned by                     0
  Each
  Reporting
  Person
  With



                        8      Shared Voting Power


                               1,405,989


                        9      Sole Dispositive Power


                               0


                        10     Shared Dispositive Power


                               1,405,989


11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                1,405,989


12
                Check if the Aggregate Amount in Row (11)
                Excludes Certain Shares (See Instructions)


13
                Percent of Class Represented by Amount in Row (11)


                7.9%

                Type of Reporting Person (See Instructions)
                PN






 CUSIP No. 766559 10 8




1               Name of Reporting Persons.
                I.R.S.Identification Nos. of above persons (entities only).

                FRAZIER AFFILIATES IV, L.P..


2               Check the Appropriate Box if a Member of a Group (
                See Instructions)

                (a)

                (b)


3               SEC Use Only

4               Source of Funds (See Instructions)


                WC


5               Check if Disclosure of Legal Proceedings Is Required
                Pursuant to Items 2(d) or 2(e)


6               Citizenship or Place of Organization


                Delaware


  Number of             7      Sole Voting Power
  Shares?
  Beneficially
  Owned by                     0
  Each
  Reporting
  Person
  With

                        8      Shared Voting Power


                               1,405,989


                        9      Sole Dispositive Power


                               0


                        10     Shared Dispositive Power


                               1,405,989

11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                1,405,989

12
                Check if the Aggregate Amount in Row (11)
                Excludes Certain Shares (See Instructions)

13
                Percent of Class Represented by Amount in Row (11)


                7.9%

14
                Type of Reporting Person (See Instructions)
                PN






 CUSIP No. 766559 10 8



1               Name of Reporting Persons.
                I.R.S.Identification Nos. of above persons (entities only).

                FHM IV, L.P.

2               Check the Appropriate Box if a Member of a Group
                (See Instructions)

                (a)

                (b)


3               SEC Use Only

4               Source of Funds (See Instructions)


                OO

5               Check if Disclosure of Legal Proceedings Is Required
                Pursuant to Items 2(d) or 2(e)


6               Citizenship or Place of Organization


                Delaware

  Number of             7      Sole Voting Power
  Shares?
  Beneficially
  Owned by                     0
  Each
  Reporting
  Person
  With


                        8      Shared Voting Power


                               1,405,989


                        9      Sole Dispositive Power


                               0


                        10     Shared Dispositive Power


                               1,405,989


11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                1,405,989


12
                Check if the Aggregate Amount in Row (11)
                Excludes Certain Shares (See Instructions)


13
                Percent of Class Represented by Amount in Row (11)


                7.9%

14
                Type of Reporting Person (See Instructions)
                PN






 CUSIP No. 766559 10 8




1               Name of Reporting Persons.
                I.R.S.Identification Nos. of above persons (entities only).

                FHM IV, L.L.C.


2               Check the Appropriate Box if a Member of a Group
                (See Instructions)

                (a)

                (b)



3               SEC Use Only



4               Source of Funds (See Instructions)


                OO



5               Check if Disclosure of Legal Proceedings Is Required
                Pursuant to Items 2(d) or 2(e)



6               Citizenship or Place of Organization


                Delaware

 ------

  Number of             7      Sole Voting Power
  Shares?
  Beneficially
  Owned by                     0
  Each
  Reporting
  Person
  With



                        8      Shared Voting Power


                               1,405,989


                        9      Sole Dispositive Power


                               0


                        10     Shared Dispositive Power


                               1,405,989


11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                1,405,989


12
                Check if the Aggregate Amount in Row (11)
                Excludes Certain Shares (See Instructions)


13
                Percent of Class Represented by Amount in Row (11)


                7.9%

14
                Type of Reporting Person (See Instructions)
                OO






 CUSIP No. 766559 10 8




1               Name of Reporting Persons.
                I.R.S.Identification Nos. of above persons (entities only).

                FRAZIER MANAGEMENT, L.L.C.


2               Check the Appropriate Box if a Member of a Group
                (See Instructions)

                (a)

                (b)



3               SEC Use Only



4               Source of Funds (See Instructions)


                OO



5               Check if Disclosure of Legal Proceedings Is Required
                Pursuant to Items 2(d) or 2(e)



6               Citizenship or Place of Organization


                Delaware



  Number of             7      Sole Voting Power
  Shares?
  Beneficially
  Owned by                     0
  Each
  Reporting
  Person
  With



                        8      Shared Voting Power


                               1,405,989


                        9      Sole Dispositive Power


                               0


                        10     Shared Dispositive Power


                               1,405,989


11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                1,405,989


12
                Check if the Aggregate Amount in Row (11)
                Excludes Certain Shares (See Instructions)


13
                Percent of Class Represented by Amount in Row (11)


                7.9%

14
                Type of Reporting Person (See Instructions)
                OO






 CUSIP No. 766559 10 8




1               Name of Reporting Persons.
                I.R.S.Identification Nos. of above persons (entities only).

                FRAZIER & COMPANY, INC.


2               Check the Appropriate Box if a Member of a Group
                (See Instructions)

                (a)

                (b)



3               SEC Use Only



4               Source of Funds (See Instructions)


                OO



5               Check if Disclosure of Legal Proceedings Is Required
                Pursuant to Items 2(d) or 2(e)



6               Citizenship or Place of Organization


                Washington



  Number of             7      Sole Voting Power
  Shares?
  Beneficially
  Owned by                     3,976
  Each
  Reporting
  Person
  With



                        8      Shared Voting Power


                               1,405,989


                        9      Sole Dispositive Power


                               3,976


                        10     Shared Dispositive Power


                               1,405,989


11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                1,409,965


12
                Check if the Aggregate Amount in Row (11)
                Excludes Certain Shares (See Instructions)


13
                Percent of Class Represented by Amount in Row (11)


                7.9%

14
                Type of Reporting Person (See Instructions)
                CO






 CUSIP No. 766559 10 8




1               Name of Reporting Persons.
                I.R.S.Identification Nos. of above persons (entities only).

                ALAN D. FRAZIER


2               Check the Appropriate Box if a Member of a Group
                (See Instructions)

                (a)

                (b)



3               SEC Use Only



4               Source of Funds (See Instructions)


                OO



5               Check if Disclosure of Legal Proceedings Is Required
                Pursuant to Items 2(d) or 2(e)



6               Citizenship or Place of Organization


                United States



  Number of             7      Sole Voting Power
  Shares
  Beneficially
  Owned by                     6,812(1)
  Each
  Reporting
  Person
  With



                        8      Shared Voting Power


                               1,405,989


                        9      Sole Dispositive Power


                               6,812(1)


                        10     Shared Dispositive Power


                               1,405,989


11
                Aggregate Amount Beneficially Owned by Each Reporting Person


                1,412,801(1)


12
                Check if the Aggregate Amount in Row (11)
                Excludes Certain Shares (See Instructions)


13
                Percent of Class Represented by Amount in Row (11)


                7.9%

14
                Type of Reporting Person (See Instructions)
                IN




(1) Includes  2,836 shares of common stock  issuable
    pursuant to stock  options
    exercisable within 60 days of April 5, 2004.


ITEM 1.  SECURITY AND ISSUER.

         This  statement  relates to shares of Common  Stock of the Issuer.  The
Issuer's  principal  executive offices are located at 1180 Veterans Blvd., South
San Francisco, California, 94080.

ITEM 2.  IDENTITY AND BACKGROUND.

         (a), (f) This statement is being filed by Frazier Healthcare II, L.P.,
a Delaware  limited  partnership  ("FH II"),
FHM II,  L.L.C., a Delaware  limited  liability  company ("FH II GP"),
Frazier  Healthcare  IV, L.P., a Delaware  limited partnership  ("FH IV"),
Frazier  Affiliates  IV, L.P., a Delaware  limited  partnership  ("FA IV"),
FHM IV, L.P., a Delaware limited  partnership  ("FHM IV GPLP"),
FHM IV,  L.L.C.,  a Delaware  limited  liability  company  ("FHM IV GPLLC"),
Frazier Management,  L.L.C.,  a Delaware  limited  liability  company  ("FM"),
Frazier & Company,  Inc.,  a  Washington  corporation
("F&Co.") and Alan D. Frazier  ("AF"), a natural  person and a citizen of
the United States  (collectively,  the  "Reporting Persons").

         FH II GP is the general  partner of FH II. F&Co. is the managing member
of FM, which in turn is the managing member of FH II GP.

         FHM IV GPLLC is the  general  partner of FHM IV GPLP,  which in turn is
the general  partner of both FH IV and FA IV. AF is a member of FHM IV GPLLC. AF
is the controlling  shareholder of F&Co. and serves as a director of the Issuer.
FM serves as the management  company of FH IV and FA IV. F&Co. also is a limited
partner of FH IV.

         (b) The address of the principal  business and principal  office of the
Reporting  Persons is Two Union Square,  601 Union  Street,  Suite 3200 Seattle,
Washington, 98101.

         (c) FH II, FA IV and FH IV are venture capital funds  concentrating  in
healthcare and related fields.  The principal  business of FH II GP, FHM IV GPLP
and FHM IV GPLLC is to serve as general  partner  entities  to  venture  capital
funds. The principal business of FM is to provide management services to venture
capital  funds.  F&Co.  is a family  holding  company  for AF.  AF is a  venture
capitalist.

         (d)  During  the  five  years  prior to the  date  hereof,  none of the
Reporting Persons has been convicted in a criminal proceeding (excluding traffic
violations or similar misdemeanors).

         (e)  During  the  five  years  prior to the  date  hereof,  none of the
Reporting  Persons has been a party to a civil proceeding  ending in a judgment,
decree  or final  order  enjoining  future  violations  of,  or  prohibiting  or
mandating activities subject to, federal or state securities laws or finding any
violation with respect to such laws.

ITEM 3.  SOURCE AND AMOUNT OF FUNDS OR OTHER CONSIDERATION.

         In connection with the Issuer's public offering of shares of its common
stock  pursuant  to  effective  registration   statements  Nos.  333-111777  and
333-106942 and the Underwriting  Agreement dated February 19, 2004, by and among
the Issuer,  the Selling  Shareholders (as defined therein) and the Underwriters
(as defined  therein),  filed as Exhibit 1.1 to Form 8-K, filed by the Issuer on
February 20, 2004,  FH IV sold 67,819  shares of common stock and FA IV sold 344
shares of common stock, as Selling  Shareholders at a price of $18.80 per share.
On March 19,  2004,  upon  exercise  by the  Underwriters  of an option to cover
over-allotments,  FH IV sold  6,819  shares  of  common  stock and FA IV sold 35
shares of common stock, each at a price of $18.80 per share.

         On February  24, 2004 FH IV  net-issue  exercised a warrant to purchase
259,101  shares of common  stock of Issuer,  which  resulted in the  issuance of
195,733 shares of common stock.  In addition,  FA IV also net-issue  exercised a
warrant to purchase  1,315 shares of common stock of Issuer,  which  resulted in
the issuance of 993 shares of common stock.  The warrant exercise price for each
was $5.76 per share.

         On April 5, 2004 FH IV  completed  a prorata  distribution  of  497,475
shares of common stock of Issuer to its partners. In connection with the prorata
distribution,  an  aggregate  of 2,294  shares  of common  stock of Issuer  were
distributed to F&Co. On April 5, 2004 FA IV sold 2,524 shares of common stock of
Issuer at price of $22.76 per share.

ITEM 4.  PURPOSE OF TRANSACTION

         The  Reporting  Persons have  acquired and disposed of shares of common
stock of Issuer for  investment  purposes  and,  through  representation  on the
Issuer's board of directors, to influence the management policies and control of
the  Issuer,  with the  purpose  of  increasing  the value of the Issuer and the
investment. AF is a director of the Issuer.

         Depending on market conditions,  continuing  evaluation of the business
and prospects of the Issuer and other factors, the Reporting Persons may dispose
of or  acquire  additional  shares  of the  common  stock of  Issuer  or  pursue
strategic transactions as opportunities arise.

         Except as set forth above, the Reporting  Persons have no present plans
or  intentions  which  would  result  in or  relate  to any of the  transactions
described in Item 4 of this Amendment No. 1 to Schedule 13D.

ITEM 5.  INTEREST IN SECURITIES OF THE ISSUER.

         (a) FH IV is the  record  holder of 919,927  shares of common  stock of
Issuer, FA IV is the record holder of 4,665 shares of common stock of Issuer, FH
II is the record holder of 481,397 shares of common stock of Issuer and F&Co. is
the record  holder of 3,976 shares of common  stock of Issuer.  AF is the record
holder of 10,556 options to purchase common stock of the Issuer,  2,836 of which
are exercisable  within 60 days of April 5, 2004. No other Reporting Persons are
record holders of securities of the Issuer.

         By virtue of the relationships among the Reporting Persons, each may be
deemed to share voting power and dispositive power of the shares of common stock
and stock options held of record by each of the Reporting Persons. Therefore, as
of the date hereof,  each of the Reporting Persons may be deemed to beneficially
own an  aggregate  of  1,409,965  shares of common stock and options to purchase
2,836 shares of common stock, which is equal to 7.9% of the Company's issued and
outstanding  shares of common  stock.  Each of the Reporting  Persons  expressly
disclaim  beneficial  ownership  of any  shares of common  stock or  options  to
purchase  common  stock,  except for such  securities  for which such  Reporting
Person is the holder of record.

         (b) Each of the  Reporting  Persons may be deemed to share voting power
and dispositive  power of the 1,409,965 shares of common stock and stock options
held of  record  by each  of the  Reporting  Persons.  AF is the  president  and
controlling  shareholder  of F&Co.,  the record holder of 3,976 shares of common
stock of Issuer.  AF is the holder of options to purchase 2,836 shares of common
stock of Issuer exercisable within 60 days of April 5, 2004.

         (c) On February 20, 2004,  FH IV sold 67,819 shares of common stock and
FA IV sold 344 shares of common  stock,  as Selling  Shareholders  at a price of
$18.80 per share. On March 19, upon exercise by the Underwriters of an option to
cover over-allotments, FH IV sold 6,819 shares of common stock and FA IV sold 35
shares of common  stock,  each at a price of $18.80 per share.  On February  24,
2004 FH IV  exercised a warrant to purchase  259,101  shares of common  stock of
Issuer and FA IV exercised a warrant to purchase 1,315 shares, each at $5.76 per
share. On April 5, 2004 FH IV completed a prorata distribution of 497,475 shares
of common  stock of Issuer to its partners and sold 2,524 shares of common stock
of  Issuer  at a price of $22.76  per  share.  In  connection  with the  prorata
distribution,  an  aggregate  of 2,294  shares  of common  stock of Issuer  were
distributed  to F&Co.  No other  transactions  were  effected  by the  Reporting
Persons in the last sixty days.

         (d) No other  person is known to have the right to receive or the power
to direct the receipt of dividends  from,  or any proceeds from the sale of, any
securities beneficially owned by the Reporting Persons.

         (e) Not applicable.

ITEM 6.  CONTRACTS, ARRANGEMENTS, UNDERTAKINGS OR RELATIONSHIPS WITH
                  RESPECT TO SECURITIES OF THE ISSUER.

         The information provided in Schedule 13D filed by the Reporting Persons
on July 7, 2003 together with the  information  provided in this Amendment No. 1
to Schedule 13D is hereby incorporated by reference.

ITEM 7.  MATERIAL TO BE FILED AS EXHIBITS.

         Not applicable.

                                    SIGNATURE

         After  reasonable  inquiry and to the best of its knowledge and belief,
each of the  undersigned  certifies  that  the  information  set  forth  in this
statement is true, complete and correct.



Date:  April 9, 2004


                                                     FRAZIER HEALTHCARE II, L.P.
                                                              By: FHM II, L.L.C.
                                                             Its General Partner
                                                  By: Frazier Management, L.L.C.
                                                             Its Managing Member
                                                     By: Frazier & Company, Inc.
                                                             Its Managing Member

                                                         By: /s/ Alan D. Frazier
                                                                 Alan D. Frazier
                                                                       President

                                                                  FHM II, L.L.C.
                                                  By: Frazier Management, L.L.C.
                                                             Its Managing Member
                                                     By: Frazier & Company, Inc.
                                                             Its Managing Member

                                                         By: /s/ Alan D. Frazier
                                                                 Alan D. Frazier
                                                                       President

                                                     FRAZIER HEALTHCARE IV, L.P.
                                                                By: FHM IV, L.P.
                                                             Its General Partner
                                                              By: FHM IV, L.L.C.
                                                             Its General Partner

                                                         By: /s/ Alan D. Frazier
                                                                 Alan D. Frazier
                                                                   Title: Member

                                                     FRAZIER AFFILIATES IV, L.P.
                                                                By: FHM IV, L.P.
                                                             Its General Partner
                                                              By: FHM IV, L.L.C.
                                                             Its General Partner

                                                         By: /s/ Alan D. Frazier
                                                                 Alan D. Frazier
                                                                   Title: Member

                                                                    FHM IV, L.P.
                                                              By: FHM IV, L.L.C.
                                                             Its General Partner

                                                         By: /s/ Alan D. Frazier
                                                                 Alan D. Frazier
                                                                   Title: Member

                                                                  FHM IV, L.L.C.

                                                         By: /s/ Alan D. Frazier
                                                                 Alan D. Frazier
                                                                   Title: Member

                                                      FRAZIER MANAGEMENT, L.L.C.
                                                     By: Frazier & Company, Inc.
                                                             Its Managing Member

                                                         By: /s/ Alan D. Frazier
                                                                 Alan D. Frazier
                                                                       President

                                                         FRAZIER & COMPANY, INC.

                                                         By: /s/ Alan D. Frazier
                                                      Alan D. Frazier, President
                                                        Director and Shareholder

                                                                 ALAN D. FRAZIER

                                                             /s/ Alan D. Frazier