Ownership Submission
FORM 3
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
OMB APPROVAL
OMB Number: 3235-0104
Expires: January 31, 2005
Estimated average burden hours per response... 0.5

(Print or Type Responses)
1. Name and Address of Reporting Person *
  STEIN EVAN A.
2. Date of Event Requiring Statement (Month/Day/Year)
11/04/2014
3. Issuer Name and Ticker or Trading Symbol
Xenon Pharmaceuticals Inc. [XENE]
(Last)
(First)
(Middle)
C/O XENON PHARMACEUTICALS INC., 200 - 3650 GILMORE WAY
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

BURNABY, A1 V5G 4W8
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)
2. Amount of Securities Beneficially Owned
(Instr. 4)
3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)
4. Nature of Indirect Beneficial Ownership
(Instr. 5)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)
2. Date Exercisable and Expiration Date
(Month/Day/Year)
3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)
4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)
6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Series B Preferred Shares   (1)   (2) Common Shares 967 (3) $ 0 I See Footnote (4)
Series E Preferred Shares   (5)   (2) Common Shares 1,038,964 (3) $ 0 I See Footnote (6)
Stock Option (Right to Buy)   (7) 06/29/2016 Common Shares 4,115 (3) $ 3.35 (8) D  
Stock Option (Right to Buy)   (9) 12/31/2016 Common Shares 1,028 (3) $ 3.21 (8) D  
Stock Option (Right to Buy)   (10) 12/31/2017 Common Shares 1,028 (3) $ 3.77 (8) D  
Stock Option (Right to Buy)   (10) 12/31/2018 Common Shares 1,028 (3) $ 3.07 (8) D  
Stock Option (Right to Buy)   (11) 12/31/2021 Common Shares 1,028 (3) $ 3.67 (8) D  
Stock Option (Right to Buy)   (12) 12/31/2022 Common Shares 1,028 (3) $ 2.68 (13) D  
Stock Option (Right to Buy)   (14) 01/13/2024 Common Shares 1,028 (3) $ 9.85 (15) D  

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
STEIN EVAN A.
C/O XENON PHARMACEUTICALS INC.
200 - 3650 GILMORE WAY
BURNABY, A1 V5G 4W8
  X      

Signatures

/s/ Barbara Mery, Attorney-in-fact for Evan A. Stein 11/04/2014
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Reflects the automatic conversion of each share of Series B Preferred Shares into one share of Common Shares to occur upon the closing of the Issuer's initial public offering.
(2) Each share has no expiration date.
(3) Reflects a 1-for-4.86 reverse stock split of the Issuer's outstanding shares effected October 1, 2014 (the "Reverse Stock Split").
(4) These shares are held by the Stein Family LLC, for which the Reporting Person serves as the managing member.
(5) Reflects the automatic conversion of each share of Series E Preferred Shares into 1.2 shares of Common Shares to occur upon the closing of the Issuer's initial public offering.
(6) These shares are held by Lipoterx, Ltd. ("Lipoterx"). Lipoterx Holdings, LLC, the general partner of Lipoterx, has sole voting and investment power with respect to the shares held by Lipoterx. The Reporting Person, the managing partner of Lipoterx Holdings, LLC has sole voting and investment power with respect to the shares held by Lipoterx.
(7) The shares subject to the option fully vested on June 30, 2008.
(8) The exercise price was converted from $3.74 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the Reverse Stock Split. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.
(9) The shares subject to the option fully vested on January 1, 2010.
(10) The shares subject to the option fully vested on January 1, 2011.
(11) 1/3 of the shares subject to the Option vested on January 1, 2013 (the "2012 Vesting Commencement Date") and thereafter the remaining 2/3 of the shares subject to the Option vest each monthly anniversary of the 2012 Vesting Commencement Date over the following 2 years.
(12) 1/3 of the shares subject to the Option vested on January 1, 2014 (the "2013 Vesting Commencement Date") and thereafter the remaining 2/3 of the shares subject to the Option vest each monthly anniversary of the 2013 Vesting Commencement Date over the following 2 years.
(13) The exercise price was converted from $2.67 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the Reverse Stock Split. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.
(14) 1/3 of the shares subject to the Option vest on January 1, 2015 (the "2014 Vesting Commencement Date") and thereafter the remaining 2/3 of the shares subject to the Option vest each monthly anniversary of the 2014 Vesting Commencement Date over the following 2 years.
(15) The exercise price was converted from $10.78 CAD using the closing rate of exchange of the Bank of Canada on the date of grant, after giving effect to the Reverse Stock Split. The actual exercise price is the Canadian dollar amount regardless of the exchange rate on the date of exercise.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB number.