Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
MCKEARN JOHN P
  2. Issuer Name and Ticker or Trading Symbol
Otonomy, Inc. [OTIC]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
C/O RIVERVEST VENTURE PARTNERS, 7733 FORSYTH BOULEVARD, SUITE 1650
3. Date of Earliest Transaction (Month/Day/Year)
08/18/2014
(Street)

ST. LOUIS, MO 63105
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 08/18/2014   C   778,052 A (1) 778,052 I See footnotes (2) (4)
Common Stock 08/18/2014   X   35,785 A $ 8.79 813,837 I See footnotes (2) (4) (7)
Common Stock 08/18/2014   S   19,660 D $ 8.79 794,177 I See footnotes (2) (4) (7)
Common Stock 08/18/2014   C   211,331 A (1) 211,331 I See footnotes (3) (4)
Common Stock 08/18/2014   X   9,720 A $ 8.79 221,051 I See footnotes (3) (4) (8)
Common Stock 08/18/2014   S   5,340 D $ 8.79 215,711 I See footnotes (3) (4) (8)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Series B Preferred Stock (1) 08/18/2014   C     155,609   (1)   (1) Common Stock 155,609 $ 0 0 I See footnotes (2) (4)
Series C Preferred Stock (1) 08/18/2014   C     481,342   (1)   (1) Common Stock 481,342 $ 0 0 I See footnotes (2) (4)
Series D Preferred Stock (1) 08/18/2014   C     141,101   (1)   (1) Common Stock 141,101 $ 0 0 I See footnotes (2) (4)
Series C Preferred Stock Warrant (right to buy) $ 8.79 08/18/2014   C     19,085 (6)   (5) 08/18/2014 Series C Preferred Stock (1) 19,085 $ 0 0 I See footnotes (2) (4)
Common Stock Warrant (right to buy) $ 8.79 08/18/2014   C   19,085 (6)     (5) 08/18/2014 Common Stock 19,085 $ 0 19,085 I See footnotes (2) (4)
Common Stock Warrant (right to buy) $ 8.79 08/18/2014   X     19,085   (5) 08/18/2014 Common Stock 19,085 $ 0 0 I See footnotes (2) (4)
Series C Preferred Stock Warrant (right to buy) $ 8.79 08/18/2014   C     16,700 (6)   (5) 08/18/2014 Series C Preferred Stock (1) 16,700 $ 0 0 I See footnotes (2) (4)
Common Stock Warrant (right to buy) $ 8.79 08/18/2014   C   16,700 (6)     (5) 08/18/2014 Common Stock 16,700 $ 0 16,700 I See footnotes (2) (4)
Common Stock Warrant (right to buy) $ 8.79 08/18/2014   X     16,700   (5) 08/18/2014 Common Stock 16,700 $ 0 0 I See footnotes (2) (4)
Series B Preferred Stock (1) 08/18/2014   C     42,265   (1)   (1) Common Stock 42,265 $ 0 0 I See footnotes (3) (4)
Series C Preferred Stock (1) 08/18/2014   C     130,741   (1)   (1) Common Stock 130,741 $ 0 0 I See footnotes (3) (4)
Series D Preferred Stock (1) 08/18/2014   C     38,325   (1)   (1) Common Stock 38,325 $ 0 0 I See footnotes (3) (4)
Series C Preferred Stock Warrant (right to buy) $ 8.79 08/18/2014   C     5,184 (8)   (5) 08/18/2014 Series C Preferred Stock (1) 5,184 $ 0 0 I See footnotes (3) (4)
Common Stock Warrant (right to buy) $ 8.79 08/18/2014   C   5,184 (8)     (5) 08/18/2014 Common Stock 5,184 $ 0 5,184 I See footnotes (3) (4)
Common Stock Warrant (right to buy) $ 8.79 08/18/2014   X     5,184   (5) 08/18/2014 Common Stock 5,184 $ 0 0 I See footnotes (3) (4)
Series C Preferred Stock Warrant (right to buy) $ 8.79 08/18/2014   C     4,536 (8)   (5) 08/18/2014 Series C Preferred Stock (1) 4,536 $ 0 0 I See footnotes (3) (4)
Common Stock Warrant (right to buy) $ 8.79 08/18/2014   C   4,536 (8)     (5) 08/18/2014 Common Stock 4,536 $ 0 4,536 I See footnotes (3) (4)
Common Stock Warrant (right to buy) $ 8.79 08/18/2014   X     4,536   (5) 08/18/2014 Common Stock 4,536 $ 0 0 I See footnotes (3) (4)

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
MCKEARN JOHN P
C/O RIVERVEST VENTURE PARTNERS
7733 FORSYTH BOULEVARD, SUITE 1650
ST. LOUIS, MO 63105
  X      

Signatures

 /s/ Paul E. Cayer, by power of attorney   08/18/2014
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Each of the Series B Convertible Preferred Stock, the Series C Convertible Preferred Stock and the Series D Convertible Preferred Stock automatically converted into Common Stock, for no additional consideration, on a one-for-one basis immediately prior to the completion of the Issuer's initial public offering of Common Stock and had no expiration date.
(2) The securities are held of record by RiverVest Venture Fund II, L.P.
(3) The securities are held of record by RiverVest Venture Fund II (Ohio), L.P.
(4) The Reporting Person is an authorized person of RiverVest Venture Partners II, LLC, the general partner of RiverVest Venture Partners II, L.P. RiverVest Venture Partners II, L.P. is the sole member of RiverVest Venture Partners II (Ohio), LLC, the general partner of RiverVest Venture Fund II (Ohio), L.P. RiverVest Venture Partners II, L.P. is also the general partner of RiverVest Venture Fund II, L.P. As an authorized person of RiverVest Venture Partners II, LLC, the Reporting Person may be deemed to share dispositive voting and investment power with respect to the shares held by these entities. The Reporting Person disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein.
(5) The warrants are immediately exercisable.
(6) The Series C Preferred Stock Warrants automatically converted into Common Stock Warrants on a one to one basis immediately prior to the completion of the Issuer's initial public offering of common stock.
(7) RiverVest Venture Fund II, L.P. exercised the warrants to purchase 35,785 shares of the Issuer's Common Stock for $8.79 per share immediately prior to the completion of the Issuer's initial public offering of common stock. RiverVest Venture Fund II, L.P. paid the exercise price on a cashless basis, resulting in the Issuer's withholding of 19,660 of the warrant shares to pay the exercise price and issuing to RiverVest Venture Fund II, L.P. the remaining 16,125 shares. The shares issued pursuant to such exercise remain subject to a 180-day lock-up restriction.
(8) RiverVest Venture Fund II (Ohio), L.P. exercised the warrants to purchase 9,720 shares of the Issuer's Common Stock for $8.79 per share immediately prior to the completion of the Issuer's initial public offering of common stock. RiverVest Venture Fund II (Ohio), L.P. paid the exercise price on a cashless basis, resulting in the Issuer's withholding of 5,340 of the warrant shares to pay the exercise price and issuing to RiverVest Venture Fund II (Ohio), L.P. the remaining 4,380 shares. The shares issued pursuant to such exercise remain subject to a 180-day lock-up restriction.

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