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Table of Contents

As filed with the Securities and Exchange Commission on November 2, 2012

Registration No. 333-        

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549



FORM S-3
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933



NuPathe Inc.
(Exact name of registrant as specified in its charter)



  Delaware
(State of other jurisdiction of
Incorporation or Organization)
  227 Washington Street, Suite 200
Conshohocken, Pennsylvania 19428
(484) 567-0130

(Address, including zip code, and telephone number,
including area code, of registrant's principal executive offices)
  75-2233445
(I.R.S. Employer
Identification No.)



Armando Anido
Chief Executive Officer
NuPathe Inc.
227 Washington Street, Suite 200
Conshohocken, Pennsylvania 19428
(484) 567-0130
(Name, address, including zip code, and telephone number, including area code, of agent for service)



Copies to:

Michael F. Marino, Esq.
Vice President and General Counsel
NuPathe Inc.
227 Washington Street, Suite 200
Conshohocken, Pennsylvania 19428
(484) 567-0130

Michael N. Peterson, Esq.
Morgan, Lewis & Bockius LLP
1701 Market Street
Philadelphia, Pennsylvania 19103
(215) 963-5000



Approximate date of commencement of proposed sale to the public:
From time to time after the effective date of this Registration Statement becomes effective.

           If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box.    o

           If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, check the following box.    ý

           If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.    o

           If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.    o

           If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box.    o

           If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box.    o

           Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer or a smaller reporting company. See the definitions of "large accelerated filer," "accelerated filer" and "smaller reporting company" in Rule 12b-2 of the Exchange Act. (Check one):

Large accelerated filer o   Accelerated filer o   Non-accelerated filer o
(Do not check if a
smaller reporting company)
  Smaller reporting company ý

CALCULATION OF REGISTRATION FEE

               
 
Title of Each Class of Securities
To Be Registered

  Amount to be
Registered(1)

  Proposed Maximum
Offering Price
Per Share(2)

  Proposed Maximum
Aggregate Offering
Price(2)

  Amount of
Registration Fee

 

Common Stock, par value $0.001 per share

  40,778,856   $3.56   $145,172,727.36   $19,801.56

 

(1)
Pursuant to Rule 416(a) under the Securities Act, this registration statement shall be deemed to cover any additional shares of common stock that become issuable as a result of stock dividends, stock splits and similar transactions effected without receipt of consideration that results in an increase in the number of outstanding shares of the registrant's common stock.

(2)
Estimated solely for the purpose of calculating the amount of registration fee pursuant to Rule 457(c) under the Securities Act. The proposed maximum offering price per share and proposed maximum aggregate offering price are based upon the average of the high $3.66 and low $3.45 sales prices of the registrant's common stock on the NASDAQ Global Market on October 31, 2012. The registrant is not selling any shares of common stock in this offering and, therefore, will not receive any proceeds from this offering.



           The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment that specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933, as amended, or until this registration statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to said Section 8(a), may determine.

   


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The information in this preliminary prospectus is not complete and may be changed. The Selling Stockholders may not sell these securities until the registration statement filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities, and the Selling Stockholders are not soliciting offers to buy these securities, in any state where the offer or sale of these securities is not permitted.

SUBJECT TO COMPLETION, DATED NOVEMBER 2, 2012

PROSPECTUS

NuPathe Inc.

40,778,856 Shares of Common Stock



        This prospectus relates to the resale or other disposition by the Selling Stockholders identified in this prospectus, or their donees, pledgees, transferees or other successors in interest, of up to an aggregate of 40,778,856 shares of common stock, representing:

        The Selling Stockholders may, from time to time, sell, transfer or otherwise dispose of any or all of their shares of common stock on any stock exchange, market or trading facility on which the shares are traded or in private transactions. These dispositions may be at fixed prices, at prevailing market prices at the time of sale, at prices related to the prevailing market price, at varying prices determined at the time of sale, or at negotiated prices. See "Plan of Distribution" for additional information.

        We are not offering any shares of common stock for sale under this prospectus, and we will not receive any of the proceeds from the sale or other disposition of the shares of common stock covered hereby.

        Our common stock is traded on the NASDAQ Global Market under the symbol "PATH." On October 31, 2012, the last reported sale price for our common stock on the NASDAQ Global Market was $3.64 per share.

        We will pay the expenses related to the registration of the shares of common stock covered by this prospectus. The Selling Stockholders will pay any commissions and selling expenses they may incur.



        Our business and an investment in our securities involve significant risks. You should read the section entitled "Risk Factors" on page 8 of this prospectus and the risk factors incorporated by reference into this prospectus as described in that section before investing in our securities.

        Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.



The date of this prospectus is                        , 2012


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TABLE OF CONTENTS

ABOUT THIS PROSPECTUS

    1  

WHERE YOU CAN FIND ADDITIONAL INFORMATION

    1  

INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

    2  

CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

    3  

PROSPECTUS SUMMARY

    5  

RISK FACTORS

    8  

USE OF PROCEEDS

    9  

SELLING STOCKHOLDERS

    10  

PLAN OF DISTRIBUTION

    15  

LEGAL MATTERS

    17  

EXPERTS

    17  

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ABOUT THIS PROSPECTUS

        This prospectus is part of a registration statement on Form S-3 that we filed with the Securities and Exchange Commission (referred to in this prospectus as, the "SEC") using a "shelf" registration or continuous offering process.

        You should read this prospectus and the information and documents incorporated by reference carefully because these documents contain important information you should consider when making your investment decision. See "Where You Can Find More Information" and "Information Incorporated by Reference."

        You should rely only on the information provided in this prospectus and the information and documents incorporated by reference into this prospectus. We have not, and the Selling Stockholders have not, authorized anyone to provide you with different information. This prospectus is not an offer to sell these securities, and the Selling Stockholders are not soliciting offers to buy these securities, in any state where the offer or sale of these securities is not permitted. The information contained in this prospectus is accurate only as of the date of this prospectus, regardless of the time of delivery of this prospectus or of any sale of shares of common stock. You should not assume that the information contained in this prospectus is accurate as of any date other than the date on the front cover of this prospectus, or that the information contained in any document incorporated by reference is accurate as of any date other than the date of the document incorporated by reference, regardless of the time of delivery of this prospectus or any sale of a security.

        In this prospectus, unless otherwise indicated or the context otherwise requires, references to "NuPathe," "we," "Company," "us," or "our" refer to NuPathe Inc., and references to "Selling Stockholders" refer to those stockholders listed herein under "Selling Stockholders," and their donees, pledgees, transferees or other successors in interest.


WHERE YOU CAN FIND ADDITIONAL INFORMATION

        We file annual, quarterly and current reports, proxy statements and other information with the SEC as required by the Securities Exchange Act of 1934, as amended (referred to in this prospects as, the "Exchange Act"). You can find, copy and inspect information we file with the SEC (including exhibits to such documents) at the SEC's Public Reference Room at 100 F Street, N.E., Room 1580, Washington, D.C. 20549. You may obtain additional information about the Public Reference Room by calling the SEC at 1-800-SEC-0330. In addition, the SEC maintains a site on the Internet at www.sec.gov which contains reports, proxy statements and other information that we file electronically with the SEC. You may also review such reports, proxy statements and other documents we file with the SEC on our website at www.nupathe.com. The information contained on our website, or accessible thereby, is not a part of this prospectus.

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INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

        We are "incorporating by reference" information into this prospectus. This means that we are disclosing important information to you by referring you to other documents that have been filed separately with the SEC. The information incorporated by reference is considered to be part of this prospectus, and information that we file later with the SEC will automatically update and supersede the information contained in documents filed earlier with the SEC or contained in this prospectus. We incorporate by reference into this prospectus the documents listed below and any future filings made by us with the SEC under Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act after the initial filing date of the registration statement of which this prospectus forms a part and prior to the termination of this offering (except in each case the information contained in such documents to the extent "furnished" and not "filed"):

        You may obtain copies, without charge, of documents incorporated by reference into this prospectus, by requesting them in writing or by telephone from us as follows:

NuPathe Inc.
227 Washington Street, Suite 200
Conshohocken Pennsylvania 19428
Attention: General Counsel
(484) 567-0130

        Exhibits to the filings will not be sent unless those exhibits have been specifically incorporated by reference into this prospectus. You may also obtain copies of documents incorporated by reference into this prospectus at the SEC's public reference room in Washington D.C., as well as through the SEC's website and our website. See "Where You Can Find More Information."

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CAUTIONARY NOTE REGARDING FORWARD-LOOKING STATEMENTS

        The information included in, or incorporated by reference into, this prospectus contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended (referred to in this prospectus as, the "Securities Act"), and Section 21E of the Exchange Act, the attainment of which involves various risks and uncertainties. All statements other than statements of historical fact included in, or incorporated by reference into, this prospectus are forward-looking statements. Forward-looking statements may be identified by the use of forward-looking terminology, such as "may," "will," "could," "would," "should," "expect," "intend," "plan," "anticipate," "believe," "estimate," "predict," "project," "potential," "scheduled," "continue," "ongoing" or similar terms, variations of those terms or the negative of those terms, although not all forward-looking statements contain these identifying words.

        Forward-looking statements are based on assumptions that we have made in light of our experience in the industry in which we operate, as well as our perceptions of historical trends, current conditions, expected future developments and other factors we believe are appropriate under the circumstances. As you read and consider this prospectus and the information incorporated by reference into this prospectus, you should understand that these statements are not guarantees of performance or results. They involve risks, uncertainties (some of which are beyond our control) and assumptions. Although we believe that these forward-looking statements are based on reasonable assumptions, you should be aware that many factors could affect our actual financial condition or results of operations and cause actual results to differ materially from those in the forward-looking statements. These factors include, among other things:

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        Additional factors that could cause actual results to differ materially from those reflected in forward-looking statements are discussed under the heading "Risk Factors" in this prospectus and in the documents incorporated by reference into this prospectus. You are cautioned not to place undue reliance on forward-looking statements.

        Forward-looking statements reflect our analysis, judgment, belief or expectation only as of the date of this prospectus or, in the case of forward-looking statements contained in documents incorporated by reference into this prospectus, the date of the applicable document (or any earlier date indicated in the statement). We undertake no obligation to update or revise forward-looking statements whether as a result of new information, future developments or otherwise. We qualify all of our forward-looking statements by these cautionary statements.

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PROSPECTUS SUMMARY

        The following is only a summary and therefore does not contain all of the information you should consider before investing in our securities. We urge you to read this entire prospectus, including the matters discussed under "Risk Factors" and the risk factors incorporated by reference into this prospectus as described in that section, and the financial statements, notes to financial statements and other information incorporated by reference from our other filings with the SEC.

Our Company

        NuPathe Inc. is a specialty pharmaceutical company focused on innovative neuroscience solutions for diseases of the central nervous system including neurological and psychiatric disorders. NuPathe's lead product candidate, Zecuity (previously referred to as Zelrix and NP101) is an active, single-use, transdermal patch being developed for the treatment of migraine. The active ingredient in Zecuity, sumatriptan, is the most prescribed treatment for migraine in the U.S. Sumatriptan is available in oral, nasal and injectable formulations but it is not currently available in a transdermal formulation because sumatriptan is not passively absorbed by the skin.

        Utilizing our SmartRelief™ technology, Zecuity is able to deliver sumatriptan through the skin by applying a mild battery power. The proprietary software in Zecuity's microprocessor manages fast, sustained and controlled drug delivery and adjusts current flow for optimal drug delivery during use without any user input or adjustment. If approved, Zecuity will be the first and only transdermal patch for the treatment of migraine.

        Migraine is a debilitating neurological disease that affects approximately 31 million people in the U.S., half of whom are diagnosed and treated. During their migraines, many patients suffer from one or more significant gastrointestinal problems, which include nausea, vomiting and a compromised ability to digest, known as decreased gastric motility. Research suggests that approximately half of the diagnosed and treated migraine patients frequently experience migraine-related nausea (> 50% of their attacks). The presence of nausea or vomiting can impede the use of oral medications, while reduced gastric motility can result in low and inconsistent absorption of oral medications which may cause some patients to fail to respond consistently to such medications. Patients who frequently experience migraine-related nausea (also referred to in this prospectus as "MRN") also report significantly more disease burden and indicate significantly less satisfaction with their current migraine medications, report more medication side effects, and report more medication-related interference in work, family, and social life.

        The American Academy of Neurology guidelines recommend a non-oral route of administration for migraine patients who experience nausea or vomiting as significant migraine symptoms. Despite this recommendation and the prevalence of nausea and vomiting, IMS Health, Incorporated, a pharmaceuticals market research firm, reported that non-oral formulations comprised only 4% of triptan units sold in the U.S. in 2010. We believe the route of administration and adverse events associated with current non-oral migraine treatments, such as nasal and injectable formulations, contribute to the low adoption rate of these medications.

        In its pivotal Phase 3 clinical trial, Zecuity achieved significance at relieving both headache pain and eliminating nausea within one hour while also providing sustained headache pain relief for 24 hours. Zecuity rapidly delivered therapeutic plasma levels of sumatriptan without reaching levels that are commonly associated with triptan sensations (pressure in chest and throat, tingling, and numbness). As a result, the incidence of triptan sensations was low without compromising the ability to address key efficacy parameters. In Zecuity's Phase 3 clinical trials, the incidence of triptan sensations was 1.5%. These compare favorably to oral (> 8%) and injectable (> 42%) sumatriptan as presented in the U.S. prescribing information for these products.

 

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        Based on its route of administration and clinical data, we believe Zecuity is uniquely positioned to meet the needs of the underserved population of patients who frequently experience MRN and for those who experience inconsistent relief or triptan sensation adverse events from their current treatment.

        We also have two proprietary product candidates in pre-clinical development that utilize our LAD™, or Long-Acting Delivery, biodegradable implant technology that allows delivery of therapeutic levels of medication over a period of months with a single dose. NP201, for the continuous symptomatic treatment of Parkinson's disease, utilizes a leading FDA-approved dopamine agonist, ropinirole, and is being developed to provide up to two months of continuous delivery. NP202, for the long-term treatment of schizophrenia and bipolar disorder, is being developed to address the long-standing problem of patient noncompliance by providing three months of continuous delivery of risperidone, an FDA-approved atypical antipsychotic.

Corporate Information

        We were organized as a corporation under the laws of the State of Delaware in January 2005. Our principal executive offices are located at 227 Washington Street, Suite 200, Conshohocken, Pennsylvania 19428 and our telephone number is (484) 567-0130. Our website address is www.nupathe.com. The information contained on our website, or accessible thereby, is not a part of this prospectus.

Financing Transaction

        On October 23, 2012, we sold 14,000,000 units of our securities to the Selling Stockholders at a per unit purchase price of $2.00, pursuant to a Securities Purchase Agreement, dated September 25, 2012, by and among us and the Selling Stockholders (such agreement is referred to in this prospectus as, the "Purchase Agreement," and the sale of securities to the Selling Stockholders pursuant to the Purchase Agreement is referred to in this prospectus as, the "Financing"). The units were sold to the Selling Stockholders pursuant to an exemption from registration afforded by Section 4(2) of the Securities Act and Rule 506 of Regulation D promulgated thereunder. Each unit consisted of one one-thousandth (1/1,000th) of a share of our newly-designated Series A Preferred Stock, which is initially convertible into one share of our common stock, and a warrant to purchase one share of our common stock from April 23, 2013 through October 23, 2017 at an initial exercise price of $2.00.

        A summary description of the Financing and the terms, rights and privileges of the Series A Preferred Stock and the warrants issued in the Financing is contained in our Current Report on Form 8-K filed with the SEC on September 26, 2012, and copies of the Purchase Agreement, Certificate of Powers, Designations, Preferences Rights and Qualifications, Limitations or Restrictions of Series A Preferred Stock and the form of warrant were filed as Exhibits 99.1, 99.2 and 99.3, respectively, to such Current Report on Form 8-K, and are incorporated herein by reference.

        Pursuant to the Purchase Agreement, we are required to prepare and file with the SEC a registration statement covering the resale or other disposition by the Selling Stockholders or their donees, pledgees, transferees or other successors in interest of an aggregate of 40,778,856 shares of common stock representing:

 

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        If we breach our obligations under the Purchase Agreement to have the registration statement declared effective or remain effective for the periods specified in the Purchase Agreement, then we will be obligated to pay liquidated damages in certain circumstances.

 

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RISK FACTORS

        An investment in our securities involves a high degree of risk. In addition to the risk factors set forth below, you should carefully consider each of the risk factors set forth under the heading "Risk Factors" in our most recent Annual Report on Form 10-K and in our subsequent Quarterly Reports on Form 10-Q, which are incorporated by reference into this prospectus. Before making an investment decision, you should carefully consider these risks as well as other information contained in, incorporated by reference into, this prospectus. The occurrence of any one or more of these risks could materially harm our business, operating results, financial condition and prospects. In these circumstances, the market price of our common stock could decline, and you may lose all or part of our investment.

Certain rights granted to the holders of our Series A Preferred Stock may make it more difficult for other stockholders to influence significant corporate decisions and may hinder a change of control.

        Certain terms of our Series A Preferred Stock may make it more difficult for other stockholders to influence significant corporate decisions. For example, the holders of our Series A Preferred Stock:

        These rights (and all other rights and privileges relating to the Series A Preferred Stock) may adversely affect the value (or perceived value) of our shares of common stock.

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USE OF PROCEEDS

        We will not receive any of the proceeds from the sale or other disposition of the shares of common stock offered hereby.

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SELLING STOCKHOLDERS

        We have prepared this prospectus to allow the Selling Stockholders or their donees, pledgees, transferees or other successors-in-interest to sell or otherwise dispose of, from time to time, up to an aggregate of 40,778,856 shares of common stock representing:

        The table below presents information regarding the Selling Stockholders, the shares of common stock beneficially owned prior to this offering and the shares of common stock that they may sell or otherwise dispose of from time to time under this prospectus. The shares of common stock covered by this prospectus may be offered or disposed of by the Selling Stockholders, from time to time, in the manner contemplated under the "Plan of Distribution." We do not know when or in what amounts the Selling Stockholders may sell or otherwise dispose of the shares of common stock covered hereby. The Selling Stockholders might not sell any or all of the shares covered by this prospectus or may sell or dispose of some or all of the shares other than pursuant to this prospectus. Because the Selling Stockholders may not sell or otherwise dispose of some or all of the shares covered by this prospectus and because there are currently no agreements, arrangements or understandings with respect to the sale or other disposition of any of the shares, we cannot estimate the number of the shares that will be held by the Selling Stockholders after completion of the offering. However, for purposes of this table, we have assumed that all of the shares of common stock covered by this prospectus will be sold by the Selling Stockholders.

        Except as noted in the footnotes below, none of the Selling Stockholders has held any position or office with us or any of our predecessors or affiliates within the last three years or has had a material

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relationship with us or any of our predecessors or affiliates within the past three years other than as a result of the ownership of our shares or other securities.

 
  Beneficial Ownership(1)  
Name of Selling Stockholder(2)
  Number of
Shares
Beneficially
Owned Prior
to the
Offering(2)
  Number of
Shares
Offered
Hereby
  Number of
Shares
Beneficially
Owned
After the
Offering(3)
  Percent of
Class
Beneficially
Owned
After the
Offering(1)(3)
 

Battelle Ventures LP(4)

    3,074,823     1,808,443     1,266,380     8.6 %

Innovation Valley Partners, LP(5)

    367,987     200,938     167,049     1.1 %

Rosalind Capital Partners L.P.(6)

    300,000     300,000     0     0 %

Rosalind Master Fund L.P.(7)

    200,000     200,000     0     0 %

David B. Musket(8)

    200,000     200,000     0     0 %

ProMed Partners, L.P.(9)

    100,000     100,000     0     0 %

Auriga Global Investors SV, SA(10)

    2,750,000     2,750,000     0     0 %

Auriga Investors Montserrat Global Fund(11)

    750,000     750,000     0     0 %

Aspire Capital Fund, LLC(12)

    655,587     500,000     155,587     1.1 %

Sabby Volatility Warrant Master Fund, Ltd.(13)

    1,000,000     1,000,000     0     0 %

Sabby Healthcare Volatility Master Fund, Ltd.(14)

    4,000,000     4,000,000     0     0 %

Capital Ventures International(15)

    450,000     450,000     0     0 %

S.R. One, Limited(16)

    4,166,846     3,000,000     1,151,211     7.8 %

Quaker Partners(17)

    8,102,712     8,102,712     0     0 %

Safeguard Delaware, Inc.(18)

    7,651,128     7,651,128     0     0 %

Midsummer Small Cap Master, Ltd(19)

    400,000     400,000     0     0 %

Joann Mostovoy(20)

    300,000     300,000     0     0 %

Cummings Bay Healthcare Fund, L.P.(21)

    420,000     420,000     0     0 %

Pyxis Long/Short Healthcare Fund(22)

    1,380,000     1,380,000     0     0 %

Prosight Fund, LP(23)

    250,000     250,000     0     0 %

(1)
Beneficial ownership is determined in accordance with Section 13(d) of the Exchange Act and generally includes voting and investment power with respect to securities and includes any securities that grant the Selling Stockholder the right to acquire shares of common stock within 60 days of October 23, 2012. For presentation purposes, we have also included in the "Number of Shares Beneficially Owned Prior to the Offering" the number of shares of common stock that may be acquired upon the exercise of warrants issued in the Financing, even though such warrants are not exercisable until April 23, 2013. Percentage ownership is calculated for each Selling Stockholder separately based on 14,763,801 shares of common stock issued and outstanding as of October 23, 2012 plus the number of shares of common stock which the Selling Stockholder may acquire within 60 days of October 23, 2012, which shares are considered outstanding and beneficially owned by such Selling Stockholder but not for the purpose of calculating the percentage of ownership of any other Selling Stockholder. As a result, "Percent of Class Beneficially Owned After the Offering" for each Selling Stockholder is calculated by dividing (x) the number of shares beneficially owned by the Selling Stockholder after the offering by (y) 14,763,801 shares of common stock issued and outstanding as of October 23, 2012, plus the number of shares of common stock that such Selling Stockholder has the right to acquire beneficial ownership of within 60 days of October 23, 2012.

(2)
Unless otherwise indicated, this table is based on information supplied to us by the Selling Stockholders and certain of our records.

(3)
This column assumes the sale of all shares of common stock offered pursuant to this prospectus.

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(4)
Includes (i) 1,266,380 shares of common stock, (ii) 8,443 shares of common stock issuable upon the exercise of a warrant within 60 days of October 23, 2012, (iii) 900,000 shares of common stock that may be acquired upon conversion of 900 shares of Series A Preferred Stock, and (iv) 900,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013. The 1,266,380 shares of common stock currently held by this Selling Stockholder are not included in the number of shares offered hereby.

Battelle Ventures, LP has indicated to us that Morton Collins, Rakefet Kasdin, Ralph Taylor-Smith and Tracy S. Warren, as the members of BVP GP, LLC, its general partner, have voting and investment power over the shares held by it.

(5)
Includes (i) 167,049 shares of common stock, (ii) 938 shares of common stock issuable upon the exercise of a warrant within 60 days of October 23, 2012, (iii) 100,000 shares of common stock that may be acquired upon conversion of 100 shares of Series A Preferred Stock, and (iv) 100,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013. The 167,049 shares of common stock currently held by this Selling Stockholder are not included in the number of shares offered hereby.

Innovation Valley Partners, LP has indicated to us that Glenn Kline, Morton Collins, Rakefet Kasdin, Ralph Taylor-Smith and Tracy S. Warren, as the members of IVP GP, LLC, its general partner, have voting and investment power over the shares held by it.

(6)
Includes (i) 150,000 shares of common stock that may be acquired upon conversion of 150 shares of Series A Preferred Stock, and (ii) 150,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013.

Rosalind Capital Partners L.P. has indicated to us that Steven A. J. Salamon has voting and investment power over the shares held by it.

(7)
Includes (i) 100,000 shares of common stock that may be acquired upon conversion of 100 shares of Series A Preferred Stock, and (ii) 100,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013.

Rosalind Master Fund L.P. has indicated to us that Steven A. J. Salamon has voting and investment power over the shares held by it.

(8)
Includes (i) 100,000 shares of common stock that may be acquired upon conversion of 100 shares of Series A Preferred Stock, and (ii) 100,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013.

(9)
Includes (i) 50,000 shares of common stock that may be acquired upon conversion of 50 shares of Series A Preferred Stock, and (ii) 50,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013.

ProMed Partners, L.P. has indicated to us that David B. Musket, its general partner, has voting and investment power over the shares held by it.

(10)
Includes (i) 1,375,000 shares of common stock that may be acquired upon conversion of 1,375 shares of Series A Preferred Stock, and (ii) 1,375,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013.

Auriga Global Investors SV, SA has indicated to us that Dr. Raj Mehra has voting and investment power over the shares held by it.

(11)
Includes (i) 375,000 shares of common stock that may be acquired upon conversion of 375 shares of Series A Preferred Stock, and (ii) 375,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013.

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(12)
Includes (i) 155,857 shares of common stock, (ii) 250,000 shares of common stock that may be acquired upon conversion of 250 shares of Series A Preferred Stock, and (iii) 250,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013. The 155,857 shares of common stock currently held by this Selling Stockholder are not included in the number of shares offered hereby.

Aspire Capital Fund, LLC has indicated to us that Steven G. Martin, Erik J. Brown and Christos Komissopoulos have voting and investment power over the shares held by it.

(13)
Includes (i) 500,000 shares of common stock that may be acquired upon conversion of 500 shares of Series A Preferred Stock, and (ii) 500,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013.

Each of Sabby Healthcare Volatility Master Fund,Ltd. and Sabby Volatility Warrant Master Fund, Ltd. (collectively, the "Sabby Funds") has indicated to us that Hal Mintz has voting and investment power over the shares held by it. Each of the Sabby Funds has also indicated to us that Sabby Management, LLC serves as its investment manager, that Hal Mintz is the manager of Sabby Management, LLC and that each of Sabby Management, LLC and Hal Mintz disclaim beneficial ownership over these shares except to the extent of any pecuniary interest therein.

(14)
Includes (i) 2,000,000 shares of common stock that may be acquired upon conversion of 2,000 shares of Series A Preferred Stock, and (ii) 2,000,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013.

Each of the Sabby Funds has indicated to us that Hal Mintz has voting and investment power over the shares held by it. Each of the Sabby Funds has also indicated to us that Sabby Management, LLC serves as its investment manager, that Hal Mintz is the manager of Sabby Management, LLC and that each of Sabby Management, LLC and Hal Mintz disclaim beneficial ownership over these shares except to the extent of any pecuniary interest therein.

(15)
Includes (i) 225,000 shares of common stock that may be acquired upon conversion of 225 shares of Series A Preferred Stock, and (ii) 225,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013.

Heights Capital Management, Inc., the authorized agent of Capital Ventures International ("CVI"), has discretionary authority to vote and dispose of the shares held by CVI and may be deemed to be the beneficial owner of these shares. Martin Kobinger, in his capacity as Investment Manager of Heights Capital Management, Inc., may also be deemed to have investment discretion and voting power over the shares held by CVI. Mr. Kobinger disclaims any such beneficial ownership of the shares.

(16)
Includes (i) 1,151,211 shares of common stock, (ii) 15,635 shares of common stock issuable upon exercise of a warrant within 60 days of October 23, 2012, (iii) 1,500,000 shares of common stock that may be acquired upon conversion of 1,500 shares of Series A Preferred Stock, and (iv) 1,500,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013. The 1,151,211 shares of common stock currently held by this Selling Stockholder are not included in the number of shares offered hereby.

(17)
Includes (i) 2,793,182 shares of common stock, (ii) 37,524 shares of common stock issuable upon the exercise of a warrant within 60 days of October 23, 2012, (iii) 2,500,000 shares of common stock that may be acquired upon conversion of 2,500 shares of Series A Preferred Stock, and (iv) 2,500,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013, over which Quaker BioVentures II, L.P. shares investment

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(18)
Ownership consists of 2,632,366 shares of common stock, 2,500,000 shares of common stock that may be acquired upon conversion of 2,500 shares of Series A Preferred Stock, 18,762 shares of common stock issuable upon the exercise of a warrant within 60 days of October 23, 2012, and 2,500,000 shares of common stock that may be acquired upon the exercise of warrants that become exercisable on April 23, 2013, held of record by Safeguard Delaware, Inc., a wholly owned subsidiary of Safeguard Scientifics, Inc. The address of Safeguard Delaware, Inc. is 1105 North Market Street, Suite 1300, Wilmington, DE 19801.

James A. Datin, Executive Vice President and Managing Director at Safeguard, and Brian J. Sisko, Senior Vice President and General Counsel at Safeguard, were appointed to our Board of Directors as "Series A Directors" in connection with, and as a condition to, the closing of the Financing. Dr. Gary Kurtzman, Senior Vice President and Managing Director at Safeguard, served as a member of our Board of Directors from 2006 to 2012.

(19)
Includes (i) 200,000 shares of common stock that may be acquired upon conversion of 200 shares of Series A Preferred Stock, and (ii) 200,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013.

Midsummer Small Cap Master, Ltd has indicated to us that Michael Amsalem and Joshua Thomas have voting and investment power over the shares held by it.

(20)
Includes (i) 150,000 shares of common stock that may be acquired upon conversion of 150 shares of Series A Preferred Stock, and (ii) 150,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013.

(21)
Includes (i) 210,000 shares of common stock that may be acquired upon conversion of 210 shares of Series A Preferred Stock, and (ii) 210,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013.

(22)
Includes (i) 690,000 shares of common stock that may be acquired upon conversion of 690 shares of Series A Preferred Stock, and (ii) 690,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013.

(23)
Includes (i) 125,000 shares of common stock that may be acquired upon conversion of 125 shares of Series A Preferred Stock, and (ii) 125,000 shares of common stock that may be acquired upon the exercise of Warrants that become exercisable on April 23, 2013.

Prosight Fund, LP has indicated to us that Lawrence Hawkins has voting and investment power over the shares held by it.

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PLAN OF DISTRIBUTION

        The Selling Stockholders may, from time to time, sell any or all of their shares of common stock on any stock exchange, market or trading facility on which the shares are traded or in private transactions. These sales may be at fixed or negotiated prices. The Selling Stockholders may use any one or more of the following methods when selling shares:

        The Selling Stockholders may also sell shares under Rule 144 under the Securities Act, if available, rather than under this prospectus.

        Broker-dealers engaged by the Selling Stockholders may arrange for other brokers-dealers to participate in sales. Broker-dealers may receive commissions or discounts from the Selling Stockholders (or, if any broker-dealer acts as agent for the purchaser of shares, from the purchaser) in amounts to be negotiated. The Selling Stockholders do not expect these commissions and discounts to exceed what is customary in the types of transactions involved. Any profits on the resale of shares of common stock by a broker-dealer acting as principal might be deemed to be underwriting discounts or commissions under the Securities Act. Discounts, concessions, commissions and similar selling expenses, if any, attributable to the sale of shares will be borne by a Selling Stockholder. The Selling Stockholders may agree to indemnify any agent, dealer or broker-dealer that participates in transactions involving sales of the shares if liabilities are imposed on that person under the Securities Act.

        The Selling Stockholders may from time to time pledge or grant a security interest in some or all of the shares of common stock owned by them and, if they default in the performance of their secured obligations, the pledgees or secured parties may offer and sell the shares of common stock from time to time under this prospectus after we have filed a supplement to this prospectus under Rule 424(b)(3) or other applicable provision of the Securities Act supplementing or amending the list of Selling Stockholders to include the pledgee, transferee or other successors in interest as Selling Stockholders under this prospectus.

        The Selling Stockholders also may transfer the shares of common stock in other circumstances, in which case the transferees, pledgees or other successors in interest will be the selling beneficial owners for purposes of this prospectus and may sell the shares of common stock from time to time under this prospectus after we have filed a supplement to this prospectus under Rule 424(b)(3) or other applicable provision of the Securities Act supplementing or amending the list of Selling Stockholders to include the pledgee, transferee or other successors in interest as Selling Stockholders under this prospectus.

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        The Selling Stockholders and any broker-dealers or agents that are involved in selling the shares of common stock may be deemed to be "underwriters" within the meaning of the Securities Act in connection with such sales. In such event, any commissions received by such broker-dealers or agents and any profit on the resale of the shares of common stock purchased by them may be deemed to be underwriting commissions or discounts under the Securities Act.

        We are required to pay all fees and expenses incident to the registration of the shares of common stock. We have agreed to indemnify the Selling Stockholders against certain losses, claims, damages and liabilities, including liabilities under the Securities Act.

        The Selling Stockholders have advised us that they have not entered into any agreements, understandings or arrangements with any underwriters or broker-dealers regarding the sale of their shares of common stock, nor is there an underwriter or coordinating broker acting in connection with a proposed sale of shares of common stock by any Selling Stockholder. If we are notified by any Selling Stockholder that any material arrangement has been entered into with a broker-dealer for the sale of shares of common stock, if required, we will file a supplement to this prospectus. If the Selling Stockholders use this prospectus for any sale of the shares of common stock, they will be subject to the prospectus delivery requirements of the Securities Act.

        The anti-manipulation rules of Regulation M under the Securities Exchange Act of 1934 may apply to sales of our common stock and activities of the Selling Stockholders.

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LEGAL MATTERS

        The validity of the shares of common stock offered hereby will be passed upon for us by Morgan, Lewis & Bockius LLP, Philadelphia, Pennsylvania.


EXPERTS

        The financial statements of NuPathe Inc. as of December 31, 2011 and 2010, and for each of the years in the three-year period ended December 31, 2011 and the period from January 7, 2005 (inception) through December 31, 2011, have been incorporated by reference herein and in the registration statement in reliance upon the report of KPMG LLP, independent registered public accounting firm, incorporated by reference herein, and upon authority of said firm as experts in accounting and auditing.

        KPMG's report dated March 20, 2012 contains an explanatory paragraph that states that NuPathe Inc.'s recurring losses and negative cash flows from operations since its inception raise substantial doubt about its ability to continue as a going concern. The financial statements do not include any adjustment that might result from the outcome of that uncertainty.

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PART II
INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14.    Other Expenses of Issuance and Distribution

        The following table lists the costs and expenses payable by the registrant in connection with the sale of the shares of common stock covered by this prospectus other than any sales commissions or discounts, which expenses will be paid by the Selling Stockholders. All amounts shown are estimates except for the SEC registration fee.

SEC registration fee

  $ 19,802  

Legal fees and expenses

    25,000  

Accounting fees and expenses

    15,000  

Miscellaneous expenses

    10,000  
       

Total

  $ 69,802  

Item 15.    Indemnification of Directors and Officers

        Section 102(b)(7) of the DGCL provides that a Delaware corporation, in its certificate of incorporation, may limit the personal liability of a director to the corporation or its stockholders for monetary damages for breach of fiduciary duties as a director, except for liability for any:

        Section 145(a) of the DGCL provides, in general, that a Delaware corporation may indemnify any person who was or is a party, or is threatened to be made a party, to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of the corporation) because that person is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation or other enterprise. The indemnity may include expenses (including attorneys' fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by the person in connection with such action, so long as the person acted in good faith and in a manner he or she reasonably believed was in or not opposed to the corporation's best interests, and, with respect to any criminal action or proceeding, had no reasonable cause to believe his or her conduct was unlawful.

        Section 145(b) of the DGCL provides, in general, that a Delaware corporation may indemnify any person who was or is a party, or is threatened to be made a party, to any threatened, pending or completed action or suit by or in the right of the corporation to obtain a judgment in its favor because the person is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation or other enterprise. The indemnity may include expenses (including attorneys' fees) actually and reasonably incurred by the person in connection with the defense or settlement of such action, so long as the person acted in good faith and in a manner the person reasonably believed was in or not opposed to the corporation's best interests, except that no indemnification shall be permitted without judicial approval if a court has determined that the person is to be liable to the corporation with respect to such claim. If a present or former director or officer has been successful in defense of any action

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referred to above, the corporation must indemnify such officer or director against the expenses (including attorneys' fees) he or she actually and reasonably incurred in connection with such action.

        Section 145(g) of the DGCL provides, in general, that a corporation may purchase and maintain insurance on behalf of any person who is or was a director, officer, employee or agent of the corporation, or is or was serving at the request of the corporation as a director, officer, employee or agent of another corporation or other enterprise against any liability asserted against and incurred by such person, in any such capacity, or arising out of his or her status as such, whether or not the corporation could indemnify the person against such liability under Section 145 of the DGCL.

        Our restated certificate of incorporation limits the liability of our directors to the fullest extent permitted under the DGCL. Our bylaws provide for the indemnification of our directors and officers to the fullest extent permitted under the DGCL.

        In addition to the indemnification provisions provided for in our restated certificate of incorporation and bylaws, we have entered into separate indemnification agreements with our directors. These indemnification agreements provide, among other things, that we will indemnify our directors for certain expenses, including damages, judgments, fines, penalties, settlements and costs and attorneys' fees and disbursements, incurred by a director in any claim, action or proceeding arising in his or her capacity as a director of our company or in connection with service at our request for another corporation or entity. The indemnification agreements also provide for procedures that will apply in the event that a director makes a claim for indemnification.

        We also maintain insurance policies which insure our directors and officers against certain liabilities.

Item 16.    Exhibits and Financial Statement Schedules

        (a)   Exhibits

Exhibit
Number
  Description
  4.1   Form of Securities Purchase Agreement (incorporated by reference to the Company's Form 8-K filed with the SEC on September 26, 2012).

 

5.1

 

Opinion of Morgan, Lewis & Bockius LLP.

 

23.1

 

Consent of KPMG LLP, Independent Registered Public Accounting Firm.

 

23.2

 

Consent of Morgan, Lewis & Bockius LLP (included in Exhibit 5.1).

 

24.1

 

Power of Attorney (included on signature page of the Registration Statement hereto).

Item 17.    Undertakings

        (a)   The undersigned registrant hereby undertakes:

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        (b)   The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act of 1933, each filing of the registrant's annual report pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 (and, where applicable, each filing of an employee benefit plan's annual report pursuant to Section 15(d) of the Securities Exchange Act of 1934) that is incorporated by reference in the registration statement shall be deemed to be a new

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registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

        (c)   Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue.

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SIGNATURES

        Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Conshohocken, Commonwealth of Pennsylvania, on this 2nd day of November, 2012.

    NUPATHE INC.

 

 

By:

 

/s/ ARMANDO ANIDO

        Name:   Armando Anido
        Title:   Chief Executive Officer


POWER OF ATTORNEY

        Each person whose individual signature appears below hereby authorizes and appoints Armando Anido and Keith A. Goldan, and each of them acting alone, his true and lawful attorney-in-fact, with full power of substitution, to execute and cause to be filed with the Securities and Exchange Commission pursuant to the requirements of the Securities Act of 1933, as amended, any and all amendments and post-effective amendments to this Registration Statement, with exhibits to such registration statements and amendments and other documents in connection therewith, and hereby ratifies and confirms all that said attorney-in-fact or his or her substitute or substitutes may do or cause to be done by virtue hereof.

        Pursuant to the requirements of the Securities Act of 1933, as amended, this Registration Statement has been signed by the following persons in the capacities and on the dates indicated.

Signature
 
Title
 
Date

 

 

 

 

 
/s/ ARMANDO ANIDO

Armando Anido
  Chief Executive Officer and Director (Principal Executive Officer)   November 2, 2012

/s/ KEITH A. GOLDAN

Keith A. Goldan

 

VP Finance and Chief Financial Officer (Principal Financial and Accounting Officer)

 

November 2, 2012

/s/ WAYNE P. YETTER

Wayne P. Yetter

 

Chairman of the Board

 

November 2, 2012

/s/ MICHAEL COLA

Michael Cola

 

Director

 

November 2, 2012

/s/ JAMES A. DATIN

James A. Datin

 

Director

 

November 2, 2012

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Signature
 
Title
 
Date

 

 

 

 

 
/s/ WILLIAM J. FEDERICI

William J. Federici
  Director   November 2, 2012

/s/ RICHARD S. KOLLENDER

Richard S. Kollender

 

Director

 

November 2, 2012

/s/ ROBERT P. ROCHE, JR.

Robert P. Roche, Jr.

 

Director

 

November 2, 2012

/s/ BRIAN J. SISKO

Brian J. Sisko

 

Director

 

November 2, 2012

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EXHIBIT INDEX

Exhibit
Number
  Description
  4.1   Form of Securities Purchase Agreement (incorporated by reference to the Company's Form 8-K filed with the SEC on September 26, 2012).

 

5.1

 

Opinion of Morgan, Lewis & Bockius LLP.

 

23.1

 

Consent of KPMG LLP, Independent Registered Public Accounting Firm.

 

23.2

 

Consent of Morgan, Lewis & Bockius LLP (included in Exhibit 5.1).

 

24.1

 

Power of Attorney (included on signature page of the Registration Statement hereto).