Looking at options trading activity among components of the Russell 3000 index, there is noteworthy activity today in Madrigal Pharmaceuticals Inc (MDGL), where a total volume of 1,108 contracts has been traded thus far today, a contract volume which is representative of approximately 110,800 underlying shares (given that every 1 contract represents 100 underlying shares). That number works out to 44.4% of MDGL's average daily trading volume over the past month, of 249,820 shares..