November 30th, 2021 – Nanjing, China – NNB Nutrition (https://nnbnutrition.com/), a leading global ingredient-focused biotech company looked at all the possibilities of MitoPrime® (its patented L-Ergothioneine), starting from cell to organ.
Ergothioneine is a thiol/thione molecule, avidly taken up from the diet by humans and other animals through a transporter, OCTN1, and accumulates to high levels in certain tissues. In 2005, Ergothioneine Transporter (ETT/OCTN1) is discovered. Concentrations of EGT are closely correlated to OCTN1 mRNA expression.
Dr. Joseph Evans, former principle investigator for Novartis Pharmaceuticals explained the importance of OCTN1: “it helps EGT to penetrate mitochondria. As an agent, the mitochondria-targeted scavenger or redox-active molecule should be bioavailable, entering the cell and accumulate inside mitochondria, and can ameliorate oxidative stress.”
NNB Nutrition commissioned an In Vitro study in the US. The principle investigator from the research group who conducted the study announced “L- Ergothioneine shows strong antioxidant capacity and is able to enter into living cells and protect them from free radical stress.”
EGT function as a physiological antioxidant. Closer examination of the distribution of EGT in the body reveals that the compound is not only accumulated in cells, but also organs and secretions predisposed to high levels of oxidative stress, such as heart, brain, liver, kidneys, etc.
Brain Health and Cognition – Supplementation with EGT dose-dependently protected cells against apoptotic death. In humans, plasma ET levels were found to be significantly decreased in subjects with mild cognitive impairment, which could happen by multiple mechanisms, such as OCTN1 transporter activity.
Heart Health – Studies showed that EGT might protect the heart by countering the harmful oxidation of myoglobin, helping to prevent damage to the heart muscle.
Kidney Protection – People with kidney issue may have lower blood EGT levels, causing increased oxidative damage. EGT may help decrease this by accumulating in the kidney.
Liver Health – EGT pretreatment protects the liver from injury by over-expression of heat shock proteins and the subsequent suppressing lipid peroxidation.
“We began series of Study Trials with L-Ergothioniene in 2020,” said Kylin Liao, NNB’s founder. “We will continue our investigative pursuit into Ergothioneine’s panoply of benefits including heart health, cognitive improvement, and immune health, mitigating the long term effects of extreme viruses such as COVID-19 as well!”
NNB is a leading ingredient-driven biotech company employing over 100 research scientists from more than 10 countries who study, design, and deliver unique ingredients to our industry to maximize health, augment performance, expand longevity and enhance appearance. NNB works in partnership with companies in the fields of nutraceuticals, food and beverage, and skin care.
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