• Testing further confirms Bentrio's broad protection against various types of airborne viruses
• Demonstrates significant reductions in viral load for preventive and mitigative treatment after 4 days vs. saline controls

HAMILTON, BERMUDA / ACCESSWIRE / June 8, 2022 / Altamira Therapeutics Ltd. (NASDAQ:CYTO), a company dedicated to developing therapeutics that address important unmet medical needs, today announced positive outcomes from testing Bentrio™ for protection in human rhinovirus (HRV) infection. Bentrio is a drug-free nasal spray developed and commercialized by the Company's affiliate Altamira Medica for protection against airborne viruses and allergens.

Bentrio was tested for its capability to prevent or mitigate infection of the human nasal epithelium by HRV (RV-16A). For the experiment, reconstituted cells from donors were inoculated with the virus either 10 minutes after the first application of Bentrio (to test the formulation's preventive effects) or 12 hours prior to the first application of Bentrio (to test the formulation's mitigative effects). Bentrio was applied daily for four days; the viral load (Tissue Culture Infectious Dose, TCID₅₀) was determined on MDCK cell lines. Prophylactic treatment with Bentrio resulted in a statistically significant reduction in the viral load vs. saline controls at Day 4 (p<0.05, two-way ANOVA), whereas mitigative treatment showed statistically significant reductions at both Day 3 and Day 4 (p<0.05 and p<0.01, respectively). On Day 4, the viral load was 89.5% and 98.9%, respectively, lower than in controls.

"These latest in vitro results obtained in human rhinovirus infection fit nicely with our previous data in SARS-CoV-2 and H1N1 infections, thus further confirming Bentrio's broad protection against various types of airborne viruses," commented Thomas Meyer, Altamira Therapeutic's founder, Chairman and CEO. "We see a great potential for Bentrio as a versatile nasal spray that is easy to use, affordable and helps to protect against the myriad of pathogens and allergens to which we are exposed in our daily lives by breathing in air."

Human rhinovirus (HRV) is the most common cause of the common cold but may also lead to more severe respiratory illness in vulnerable populations such as people with weakened immune systems, asthma, or respiratory conditions. According to the US Centers for Disease Control and Prevention, each year in the United States, there are millions of cases of the common cold. Adults have an average of 2-3 colds per year, and children have even more. Most people get colds in the winter and spring, but it is possible to get a cold any time of the year. Medications for "Cough and cold" represent one of the most important "Over the counter" product categories.

About Bentrio
Bentrio is a drug-free nasal spray for personal protection against airborne viruses and allergens. Upon application into the nose, Bentrio forms a protective gel layer on the nasal mucosa. This thin film is designed to prevent the contact of viruses or allergens with cells; in addition, the composition serves to bind such particles and help with their discharge and to humidify the nasal mucosa. Together, this is designed to reduce the risk of upper respiratory tract viral infections and promote alleviation of allergic symptoms. For more info, visit:

https://altamiratherapeutics.com/our-products/bentrio.

Bentrio is being distributed in selected European countries and is expected to become available through distributors in further countries in Europe, Asia and MENA. In the US, Altamira submitted a 510(k) application of Bentrio in the treatment of allergic rhinitis, which is currently under review by the FDA.

About Altamira Therapeutics
Altamira Therapeutics (NASDAQ:CYTO) is dedicated to developing therapeutics that address important unmet medical needs. The Company is currently active in three areas: the development of RNA therapeutics for extrahepatic therapeutic targets (OligoPhore™ / SemaPhore™ platforms; preclinical), nasal sprays for protection against airborne viruses and allergens (Bentrio™; commercial) or for the treatment of vertigo (AM-125; Phase 2), and the development of therapeutics for intratympanic treatment of tinnitus or hearing loss (Keyzilen® and Sonsuvi®; Phase 3). Founded in 2003, it is headquartered in Hamilton, Bermuda, with its main operations in Basel, Switzerland. For more information, visit: https://altamiratherapeutics.com/.

Forward-Looking Statements
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CONTACT
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SOURCE: Altamira Therapeutics