--------------------------
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                                                      --------------------------
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                                                      hours per response......11
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                              Washington, DC 20549

                                  SCHEDULE 13G

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 1)*


                       Ligand Pharmaceuticals Incorporated
--------------------------------------------------------------------------------
                                (Name of Issuer)


                    Common Stock, par value $0.001 per share
--------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                    53220K207
--------------------------------------------------------------------------------
                                 (CUSIP Number)


                                December 31, 2004
--------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

|_|      Rule 13d-1(b)
|X|      Rule 13d-1(c)
|_|      Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

                         (Continued on following pages)
                               Page 1 of 29 Pages





                                       13G
===================
CUSIP No. 53220K207
===================


------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Farallon Capital Partners, L.P.
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            California
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         -------------==========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    791,661 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     791,661 [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            791,661 [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            1.1% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            PN
------------====================================================================


                               Page 2 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Farallon Capital Institutional Partners, L.P.
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            California
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    725,008 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     725,008 [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            725,008 [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            1.0% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            PN
------------====================================================================


                               Page 3 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Farallon Capital Institutional Partners II, L.P.
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            California
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    131,323 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     131,323 [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            131,323 [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            0.2% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            PN
------------====================================================================


                               Page 4 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Farallon Capital Institutional Partners III, L.P.
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            Delaware
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    94,811 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     94,811 [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            94,811 [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            0.1 % [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            PN
------------====================================================================


                               Page 5 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Tinicum Partners, L.P.
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            New York
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    31,588 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     31,588 [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            31,588 [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            0.0% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            PN
------------====================================================================


                               Page 6 of 29 Pages


                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            RR Capital Partners, L.P.
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            Delaware
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    17,850 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     17,850 [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            17,850 [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            0.0% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            PN
------------====================================================================


                               Page 7 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Farallon Capital Management, L.L.C.
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            Delaware
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    1,610,186 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     1,610,186 [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            1,610,186 [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            2.1% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            IA, OO
------------====================================================================


                               Page 8 of 29 Pages


                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Farallon Partners, L.L.C.
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            Delaware
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         -------------==========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    1,792,241 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     1,792,241 [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            1,792,241 [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            2.4% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            OO
------------====================================================================


                               Page 9 of 29 Pages


                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            David I. Cohen [See Second Preliminary Note]
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First and Second Preliminary Notes]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            United States
------------====================================================================
                                     SOLE VOTING POWER
                             5
                                     -0-
         NUMBER OF       ------------===========================================
                                     SHARED VOTING POWER
          SHARES             6
       BENEFICIALLY                  3,402,427
         OWNED BY                    [See First and Second Preliminary Notes]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      -------------==========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     3,402,427
                                     [See First and Second Preliminary Notes]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            3,402,427 [See First and Second Preliminary Notes]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            4.4% [See First and Second Preliminary Notes]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            IN
------------====================================================================


                              Page 10 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Chun R. Ding
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            United States
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    3,402,427 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     3,402,427  [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            3,402,427  [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            4.4% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            IN
------------====================================================================


                              Page 11 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Joseph F. Downes
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            United States
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    3,402,427 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     3,402,427  [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            3,402,427 [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            4.4% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            IN
------------====================================================================


                              Page 12 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            William F. Duhamel
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            United States
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    3,402,427 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     3,402,427  [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            3,402,427  [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            4.4% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            IN
------------====================================================================


                              Page 13 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Charles E. Ellwein
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            United States
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    3,402,427 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     3,402,427 [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            3,402,427 [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            4.4% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            IN
------------====================================================================


                              Page 14 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Richard B. Fried
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            United States
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    3,402,427  [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     3,402,427 [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            3,402,427 [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            4.4% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            IN
------------====================================================================


                              Page 15 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Monica R. Landry
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            United States
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    3,402,427 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     3,402,427 [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            3,402,427 [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            4.4% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            IN
------------====================================================================


                              Page 16 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            William F. Mellin
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            United States
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         -------------==========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    3,402,427  [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     3,402,427  [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            3,402,427  [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            4.4% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            IN
------------====================================================================


                              Page 17 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Stephen L. Millham
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            United States
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    3,402,427 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     3,402,427  [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            3,402,427 [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            4.4% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            IN
------------====================================================================


                              Page 18 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Rajiv A. Patel
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            United States
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    3,402,427 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     3,402,427 [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            3,402,427 [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            4.4% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            IN
------------====================================================================


                              Page 19 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Derek C. Schrier
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            United States
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    3,402,427 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     3,402,427 [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            3,402,427 [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            4.4% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            IN
------------====================================================================


                              Page 20 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Thomas F. Steyer
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            United States
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    3,402,427 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     3,402,427 [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            3,402,427 [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            4.4% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            IN
------------====================================================================


                              Page 21 of 29 Pages



                                       13G
===================
CUSIP No. 53220K207
===================

------------====================================================================
            NAMES OF REPORTING PERSONS
    1       I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

            Mark C. Wehrly
------------====================================================================
            CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions)
                                                              (a) [   ]
                                                              (b) [ X ]**
    2
                  **       The  reporting  persons  making  this  filing  may be
                           deemed  the  beneficial  owners  of an  aggregate  of
                           3,402,427  Shares,  which  is  4.4% of the  class  of
                           securities.  The reporting person on this cover page,
                           however,  may be deemed the beneficial  owner only of
                           the  securities  reported  by it on this cover  page.
                           [See First Preliminary Note]
------------====================================================================
    3       SEC USE ONLY

------------====================================================================
            CITIZENSHIP OR PLACE OF ORGANIZATION
    4
            United States
------------====================================================================
                                     SOLE VOTING POWER
                             5
         NUMBER OF                   -0-
                         ------------===========================================
          SHARES                     SHARED VOTING POWER
       BENEFICIALLY          6
         OWNED BY                    3,402,427 [See First Preliminary Note]
                         ------------===========================================
           EACH                      SOLE DISPOSITIVE POWER
                             7
         REPORTING                   -0-
        PERSON WITH      ------------===========================================
                                     SHARED DISPOSITIVE POWER
                             8
                                     3,402,427 [See First Preliminary Note]
------------====================================================================
            AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
    9
            3,402,427  [See First Preliminary Note]
------------====================================================================
            CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
    10      CERTAIN SHARES (See Instructions)
                                                                  [   ]
------------====================================================================
            PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    11
            4.4% [See First Preliminary Note]
------------====================================================================
            TYPE OF REPORTING PERSON (See Instructions)
    12
            IN
------------====================================================================


                              Page 22 of 29 Pages



         This  Amendment No. 1 to Schedule 13G amends the Schedule 13G initially
filed on  November  8, 2004  (collectively,  with all  amendments  thereto,  the
"Schedule 13G").

         First  Preliminary  Note: The Reporting  Persons (as defined below) are
filing this Schedule 13G with respect to the shares of Common  Stock,  par value
$0.001 per share (the "Shares"),  of Ligand  Pharmaceuticals  Incorporated  (the
"Company").  Certain of the Reporting Persons own, in aggregate, (i) $18,800,000
principal amount of 6% Convertible Subordinated Notes due 2007 (the "Convertible
Notes") issued by the Company, each $1,000 principal amount of Convertible Notes
immediately  convertible to 161.9905 Shares,  and (ii) Warrants (the "Warrants")
issued by the Company to purchase  357,006 Shares.  Each Warrant has an exercise
price of $10 per Share, is immediately exercisable and has an expiration date of
October 6, 2006. If all of such Convertible Notes and Warrants were converted or
exercised,  as  applicable,  the  Reporting  Persons  would own,  in  aggregate,
3,402,427  Shares.  All numbers and  percentages  contained in this Schedule 13G
represent   Shares  and  not  Convertible   Notes  or  Warrants  (unless  stated
otherwise).  For information  regarding the Convertible Notes, see the Company's
Registration  Statement  on a Form S-3 filed with the  Securities  and  Exchange
Commission  on January 13,  2003,  as amended.  For  information  regarding  the
Warrants,  see the  Company's  Annual  Statement  on a Form 10K  filed  with the
Securities and Exchange Commission on March 21, 2003, as amended.
         Second  Preliminary  Note:  Effective  as of January  1, 2005,  each of
Noonday G.P. (U.S.),  L.L.C. (the "First Noonday Sub-adviser") and Noonday Asset
Management,  L.P. (the "Second Noonday  Sub-adviser") entered into an investment
subadvisory agreement with the Management Company and the General Partner, under
which the First  Noonday  Sub-adviser  and the Second  Noonday  Sub-adviser  are
granted  investment  authority over certain  securities and


                              Page 23 of 29 Pages



instruments owned by thePartnerships and Managed Accounts,  including the Shares
reported herein.  Noonday Capital,  L.L.C.  serves as the general partner of the
Second Noonday Sub-adviser.  David I. Cohen serves as the managing member of the
First Noonday  Sub-adviser and Noonday  Capital,  L.L.C. Mr. Cohen resigned as a
managing  member of the  Management  Company and the General  Partner  effective
December 31, 2004.  This amendment to the Schedule 13G reports that Mr. Cohen is
no longer the deemed  beneficial  owner of any of the Shares  reported herein by
virtue of being a managing  member of the  Management  Company  and the  General
Partner. Mr. Cohen,  however, may be deemed to be the beneficial owner of all of
the Shares reported herein by virtue of his position as a managing member of the
First Noonday Sub-adviser and Noonday Capital, L.L.C.

Item 1.  Issuer
         ------

         (a)      Name of Issuer:
                  --------------

                  Ligand Pharmaceuticals Incorporated (the "Company")

         (b)      Address of Issuer's Principal Executive Offices:
                  -----------------------------------------------

                  10275 Science Center Drive, San Diego, CA, 92121-1117

Item 2.  Identity And Background
         -----------------------

         Title Of Class Of Securities And CUSIP Number (Item 2(d) and (e))
         ----------------------------------------------------------------

         This  statement  relates  to Shares of the  Company  (each such term as
defined in the First Preliminary Note above).  The CUSIP number of the Shares is
53220K207.

         Name Of Persons Filing, Address Of Principal Business Office And
         ----------------------------------------------------------------
         Citizenship (Item 2(a), (b) and (c))
         ------------------------------------

         This statement is filed by the entities and persons  listed below,  all
of whom together are referred to herein as the "Reporting Persons."


                              Page 24 of 29 Pages




         The Partnerships
         ----------------

                  (i)    Farallon Capital Partners, L.P., a California limited
                         partnership ("FCP"), with respect to the Shares
                         beneficially owned by it through its ownership of
                         Convertible Notes and/or Warrants;

                  (ii)   Farallon Capital Institutional Partners, L.P., a
                         California limited partnership ("FCIP"), with respect
                         to the Shares beneficially owned by it through its
                         ownership of Convertible Notes and/or Warrants;

                  (iii)  Farallon Capital Institutional Partners II, L.P., a
                         California limited partnership ("FCIP II"), with
                         respect to the Shares beneficially owned by it through
                         its ownership of Convertible Notes and/or Warrants;

                  (iv)   Farallon Capital Institutional Partners III, L.P., a
                         Delaware limited partnership ("FCIP III"), with respect
                         to the Shares beneficially owned by it through its
                         ownership of Convertible Notes and/or Warrants;

                  (v)    Tinicum Partners, L.P., a New York limited partnership
                         ("Tinicum"), with respect to the Shares beneficially
                         owned by it through its ownership of Convertible Notes
                         and/or Warrants; and

                  (vi)   RR Capital Partners, L.P., a Delaware limited
                         partnership ("RR"), with respect to the Shares
                         beneficially owned by it through its ownership of
                         Convertible Notes and/or Warrants.

         FCP, FCIP, FCIP II, FCIP III, Tinicum and RR are together referred to
herein as the "Partnerships."

         The Management Company
         ----------------------

                  (vii)  Farallon Capital Management, L.L.C., a Delaware limited
                         liability company (the "Management Company"), with
                         respect to the Shares beneficially owned by certain
                         accounts managed by the Management Company (the
                         "Managed Accounts") through their ownership of
                         Convertible Notes and/or Warrants.

         The General Partner Of The Partnerships
         ---------------------------------------

                  (viii) Farallon Partners, L.L.C., a Delaware limited liability
                         company which is the general partner of each of the
                         Partnerships (the "General Partner"), with respect to
                         the Shares beneficially owned by each of the
                         Partnerships through their ownership of Convertible
                         Notes and/or Warrants.


                              Page 25 of 29 Pages


         The Managing Members Of the General Partner And The Management Company
         ----------------------------------------------------------------------

                  (ix)   The following persons who are (or, solely with respect
                         to David I. Cohen, were) managing members of both the
                         General Partner and the Management Company, with
                         respect to the Shares held by the Partnerships and the
                         Managed Accounts: David I. Cohen ("Cohen"), Chun R.
                         Ding ("Ding"), Joseph F. Downes ("Downes"), William F.
                         Duhamel ("Duhamel"), Charles E. Ellwein ("Ellwein"),
                         Richard B. Fried ("Fried"), Monica R. Landry
                         ("Landry"), William F. Mellin ("Mellin"), Stephen L.
                         Millham ("Millham"), Rajiv A. Patel ("Patel"), Derek C.
                         Schrier ("Schrier"), Thomas F. Steyer ("Steyer") and
                         Mark C. Wehrly ("Wehrly").

         Cohen, Ding, Downes, Duhamel,  Ellwein, Fried, Landry, Mellin, Millham,
Patel,  Schrier,  Steyer  and  Wehrly  are  together  referred  to herein as the
"Individual Reporting Persons."

         The  citizenship of each of the  Partnerships,  the General Partner and
the  Management  Company is set forth above.  Each of the  Individual  Reporting
Persons is a United States citizen. The address of the principal business office
of each of the  Reporting  Persons  other  than  Cohen is c/o  Farallon  Capital
Management,  L.L.C., One Maritime Plaza,  Suite 1325, San Francisco,  California
94111.  The  address of the  principal  business  office of Cohen is c/o Noonday
Asset  Management,  L.P., 227 West Trade Street,  Suite 2140,  Charlotte,  North
Carolina 28202.

Item 3.  If This Statement Is Filed Pursuant To Sections 240.13d-1(b) or
         ---------------------------------------------------------------
         240.13d-2(b) or (c), Check Whether The Person Filing Is An Entity
         -----------------------------------------------------------------
         Specified in (a) - (j):
         -----------------------

                  Not Applicable.

         If This Statement Is Filed Pursuant To Section 240.13d-1(c), Check This
         -----------------------------------------------------------------------
         Box. [X]
         ---

Item 4.  Ownership
         ---------

         The  information  required  by Items 4(a) - (c) and set forth in Rows 5
through 11 of the cover page for each  Reporting  Person hereto is  incorporated
herein by reference for each such Reporting Person.

         The Shares reported hereby for the Partnerships are beneficially  owned
by the  Partnerships  and those reported by the Management  Company on behalf of
the Managed  Accounts are  beneficially  owned by the Managed  Accounts  through
their ownership of Convertible  Notes and/or Warrants.  The General Partner,  as
general partner to the Partnerships, may be deemed to be the beneficial owner of
all such Shares beneficially owned by the Partnerships.  The Management Company,
as  investment  adviser  to  the  Managed  Accounts,  may  be  deemed  to be the
beneficial owner of all such Shares  beneficially owned by the Managed Accounts.
The Individual  Reporting  Persons other than Cohen, as managing members of both
the General  Partner and the  Management  Company,  may each be deemed to be the
beneficial owner of all such Shares  beneficially  owned by the Partnerships and
the  Managed  Accounts.  Cohen,  as a  managing  member  of  the  First  Noonday
Sub-adviser  and Noonday  Capital,  L.L.C.,


                              Page 26 of 29 Pages



may be deemed to be the beneficial owner of all such Shares  beneficially  owned
by the Partnerships and Managed Accounts.  Each of the Management  Company,  the
General  Partner and the  Individual  Reporting  Persons  hereby  disclaims  any
beneficial ownership of any such Shares.

Item 5.  Ownership Of Five Percent Or Less Of A Class
         --------------------------------------------

                  If this statement is being filed to report the fact that as of
                  the date hereof the  Reporting  Persons  have ceased to be the
                  deemed beneficial owner of more than five percent of the class
                  of securities, check the following: [X]

Item 6.  Ownership Of More Than Five Percent On Behalf Of Another Person
         ---------------------------------------------------------------

                  Not Applicable.

Item 7.  Identification And Classification Of The Subsidiary Which Acquired
         ------------------------------------------------------------------
         The Security Being Reported On By The Parent Holding Company
         ------------------------------------------------------------

                  Not Applicable.

Item 8.  Identification And Classification Of Members Of The Group
         ---------------------------------------------------------

                  The Reporting Persons are filing this Schedule 13G pursuant to
         Rule  13d-1(c).  Consistent  with  Item 2 of the  cover  page  for each
         Reporting  Person above,  the Reporting  Persons  neither  disclaim nor
         affirm the existence of a group among them.

Item 9.  Notice Of Dissolution Of Group
         ------------------------------

                  Not Applicable.

Item 10. Certification
         -------------

                  By signing  below I certify  that, to the best of my knowledge
         and belief, the securities  referred to above were not acquired and are
         not  held  for the  purpose  of or  with  the  effect  of  changing  or
         influencing  the control of the issuer of the  securities  and were not
         acquired and are not held in connection with or as a participant in any
         transaction having that purpose or effect.


                              Page 27 of 29 Pages



                                   SIGNATURES
                                   ----------

         After  reasonable  inquiry and to the best of our knowledge and belief,
the  undersigned  certify that the  information  set forth in this  statement is
true, complete and correct.


Dated:  January 25, 2005


                        /s/ Joseph F. Downes
                     ----------------------------------------
                     FARALLON PARTNERS, L.L.C.,
                     on its own behalf and as General Partner of
                     FARALLON CAPITAL PARTNERS, L.P.,
                     FARALLON CAPITAL INSTITUTIONAL PARTNERS, L.P.,
                     FARALLON CAPITAL INSTITUTIONAL PARTNERS II, L.P.,
                     FARALLON CAPITAL INSTITUTIONAL PARTNERS III, L.P.,
                     TINICUM PARTNERS, L.P.,
                     And RR CAPITAL PARTNERS, L.P.,
                     By Joseph F. Downes
                     Managing Member

                        /s/ Joseph F. Downes
                     ----------------------------------------
                     FARALLON CAPITAL MANAGEMENT, L.L.C.,
                     By Joseph F. Downes
                     Managing Member

                        /s/ Joseph F. Downes
                     ----------------------------------------
                     Joseph F. Downes, individually and as attorney-in-fact for
                     each of David I. Cohen, Chun R. Ding, William F. Duhamel,
                     Charles E. Ellwein, Richard B. Fried, Monica R. Landry,
                     William F. Mellin, Stephen L. Millham, Rajiv A. Patel,
                     Derek C. Schrier, Thomas F. Steyer and Mark C. Wehrly.

         The Powers of Attorney, each executed by Cohen, Mellin, Millham and
Steyer authorizing Downes to sign and file this Schedule 13G on each person's
behalf, which were filed with Amendment No. 1 to the Schedule 13D filed with the
Securities and Exchange Commission on January 20, 1998, by such Reporting
Persons with respect to the Units of Spiros Development Corporation II, Inc.,
are hereby incorporated by reference. The Powers of Attorney, each executed by
Duhamel and Fried authorizing Downes to sign and file this Schedule 13G on each
person's behalf, which were filed with Amendment No. 7 to the Schedule 13D filed
with the Securities and Exchange Commission on February 9, 1999 by such
Reporting Persons with respect to the Callable Class A Common Stock of Crescendo
Pharmaceuticals Corporation, are hereby incorporated by reference. The Power of
Attorney executed by Mark C. Wehrly authorizing Downes to sign and file this
Schedule 13G on his behalf, which was filed with Amendment No. 4 to the Schedule
13D filed with the Securities and Exchange Commission on January 18, 2000, by
such Reporting Person with respect to the Class A Common Stock of Momentum
Business Applications, Inc., is hereby incorporated by reference. The Power of
Attorney executed by Monica R. Landry authorizing Downes, as well as Steyer and
Cohen, to


                              Page 28 of 29 Pages



sign and file this Schedule 13G on her behalf, which was filed with the Schedule
13G filed with the  Securities  and Exchange  Commission on January 22, 2001, by
such   Reporting   Person  with  respect  to  the  Common  Stock  of  Korn/Ferry
International  is hereby  incorporated  by  reference.  The  Powers of  Attorney
executed by each of Chun R. Ding and Derek C. Schrier authorizing Downes to sign
and file this Schedule 13G on his behalf,  which was filed with  Amendment No. 1
to the Schedule 13D filed with the Securities and Exchange Commission on July 2,
2003,  by such  Reporting  Person  with  respect  to the  Common  Stock of Salix
Pharmaceuticals,  Ltd.,  is hereby  incorporated  by  reference.  The  Powers of
Attorney  executed by each of Charles E. Ellwein and Rajiv A. Patel  authorizing
Downes to sign and file this  Schedule  13G on his behalf,  which was filed with
Amendment  No. 4 to the  Schedule  13G filed with the  Securities  and  Exchange
Commission  on  January 8, 2004 by such  Reporting  Person  with  respect to the
Common Stock of  Catalytica  Energy  Systems,  Inc., is hereby  incorporated  by
reference.


                              Page 29 of 29 Pages