FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * Warren Howland Shaw   2. Issuer Name and Ticker or Trading Symbol CRITICAL THERAPEUTICS INC [CRTX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) C/O CRITICAL THERAPEUTICS, INC., 60 WESTVIEW STREET 3. Date of Earliest Transaction (Month/Day/Year) 12/19/2003 (Street) LEXINGTON, MA 02421 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 12/19/2003   G V 24,000 D (1) 284,888 D   Common Stock 06/02/2004   P   1,000 A $ 7 285,888 D

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

Options (Right to Buy)

$ 1.05

12/19/2003

A

85,426

(2)

12/19/2019

Common Stock

85,426

(1)

85,426

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Warren Howland Shaw C/O CRITICAL THERAPEUTICS, INC. 60 WESTVIEW STREET LEXINGTON, MA 02421	X

Signatures

/s/ Scott B. Townsend, Attorney-in-Fact		10/21/2005
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Not applicable
(2)	Of the 85,426 shares of common stock underlying this option, 21,357 shares vested on December 19, 2003. 5,340 of the shares vested on December 19, 2004. 12,813 of the shares vested on December 31, 2004. 16,018 of the shares vest in 36 equal monthly installments beginning on January 19, 2005. 1,424 of the underlying shares vest on December 31, 2007. Based on the satisfaction of certain performance objectives as determined by the issuer, 14,327 shares vest on December 31, 2005 and 14,237 vest on December 31, 2006, provided that any of such shares that remain unvested shall vest on December 31, 2007.
Remarks: This Form 4 is being filed to report the purchase of 1,000 shares of common stock in the issuer's IPO on June 2, 2004, which the reporting person inadvertently failed to report.  As this Form 4 would have been the first Form 4 required to be filed following the reporting person's becoming subject to Section 16(a) of the Securities Exchange Act, this Form 4 also reflects transactions occuring within six months prior to the transaction giving rise to the obligation to file this Form 4.

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