PAGE 1 000 B000000 12/31/2008 000 C000000 0001227476 000 D000000 N 000 E000000 NF 000 F000000 Y 000 G000000 N 000 H000000 N 000 I000000 6.1 000 J000000 A 001 A000000 NUVEEN MULTI-STRATEGY INCOME & GROWTH FUND 2 001 B000000 811-21333 001 C000000 3129178200 002 A000000 333 WEST WACKER DRIVE 002 B000000 CHICAGO 002 C000000 IL 002 D010000 60606 002 D020000 1286 003 000000 N 004 000000 N 005 000000 N 006 000000 N 007 A000000 N 007 B000000 0 007 C010100 1 007 C010200 2 007 C010300 3 007 C010400 4 007 C010500 5 007 C010600 6 007 C010700 7 007 C010800 8 007 C010900 9 007 C011000 10 007 C011100 11 007 C011200 12 007 C011300 13 007 C011400 14 007 C011500 15 007 C011600 16 007 C011700 17 007 C011800 18 007 C011900 19 007 C012000 20 007 C012100 21 007 C012200 22 007 C012300 23 007 C012400 24 007 C012500 25 007 C012600 26 007 C012700 27 007 C012800 28 PAGE 2 007 C012900 29 007 C013000 30 007 C013100 31 007 C013200 32 007 C013300 33 007 C013400 34 007 C013500 35 007 C013600 36 007 C013700 37 007 C013800 38 007 C013900 39 007 C014000 40 007 C014100 41 007 C014200 42 007 C014300 43 007 C014400 44 007 C014500 45 007 C014600 46 007 C014700 47 007 C014800 48 007 C014900 49 007 C015000 50 008 A000001 NUVEEN ASSET MANAGEMENT 008 B000001 A 008 C000001 801-14147 008 D010001 CHICAGO 008 D020001 IL 008 D030001 60606 008 D040001 1286 008 A000002 SPECTRUM ASSET MANAGEMENT, INC. 008 B000002 S 008 C000002 801-30405 008 D010002 STAMFORD 008 D020002 CT 008 D030002 06905 008 A000003 TRADEWINDS GLOBAL INVESTORS, LLC. 008 B000003 S 008 C000003 801-65208 008 D010003 LOS ANGELES 008 D020003 CA 008 D030003 90067 008 A000004 SYMPHONY ASSET MANAGEMENT, LLC. 008 B000004 S 008 C000004 801-52638 008 D010004 SAN FRANCISCO 008 D020004 CA 008 D030004 94104 012 A000001 EQUISERVE INC. 012 B000001 84-05925 012 C010001 PROVIDENCE 012 C020001 RI PAGE 3 012 C030001 02940 013 A000001 ERNST & YOUNG LLP 013 B010001 CHICAGO 013 B020001 IL 013 B030001 60606 014 A000001 NUVEEN INVESTMENTS, LLC 014 B000001 8-13464 014 A000002 SPECTRUM ASSET MANAGEMENT, INC. 014 B000002 8-36472 014 A000003 DELETE 014 A000004 DELETE 015 A000001 STATE STREET BANK AND TRUST COMPANY 015 B000001 C 015 C010001 BOSTON 015 C020001 MA 015 C030001 02110 015 E010001 X 018 000000 Y 019 A000000 Y 019 B000000 192 019 C000000 NUVEENFUND 020 A000001 SPECTRUM ASSET MANAGEMENT, INC 020 B000001 06-1209521 020 C000001 516 020 A000002 JEFFERIES + COMPANY INC 020 B000002 95-2622900 020 C000002 153 020 A000003 BEAR STEARNS 020 B000003 13-3604093 020 C000003 91 020 A000004 BANCAMERICA 020 B000004 56-2058405 020 C000004 88 020 A000005 ITG INC 020 B000005 95-2848406 020 C000005 87 020 A000006 MORGAN STANLEY 020 B000006 13-2655998 020 C000006 41 020 A000007 UBS 020 B000007 13-2638166 020 C000007 36 020 A000008 INSTINET CORP 020 B000008 13-3443395 020 C000008 31 020 A000009 RBC DOMINION SECURITIES INC. 020 B000009 13-5033225 020 C000009 29 020 A000010 JPMORGAN CHASE 020 B000010 13-3224016 020 C000010 26 PAGE 4 021 000000 1245 022 A000001 SPECTRUM ASSET MANAGEMENT, INC. 022 B000001 06-1209521 022 C000001 177187 022 D000001 443095 022 A000002 ITG 022 B000002 95-2848406 022 C000002 115944 022 D000002 196501 022 A000003 UBS 022 B000003 13-2638166 022 C000003 65739 022 D000003 90647 022 A000004 INSTINET CORP 022 B000004 13-3443395 022 C000004 72590 022 D000004 50272 022 A000005 GOLDMAN SACHS 022 B000005 13-5108880 022 C000005 44750 022 D000005 47736 022 A000006 ROBERT FLEMING 022 B000006 13-3298866 022 C000006 24435 022 D000006 51035 022 A000007 MORGAN STANLEY 022 B000007 13-2655998 022 C000007 38581 022 D000007 32502 022 A000008 BANK OF AMERICA 022 B000008 56-2058405 022 C000008 37409 022 D000008 30575 022 A000009 HSBC 022 B000009 13-2650272 022 C000009 12984 022 D000009 45022 022 A000010 JEFFEREIES & CO 022 B000010 95-2622900 022 C000010 30841 022 D000010 25253 023 C000000 776387 023 D000000 1154393 024 000000 N 025 D000001 0 025 D000002 0 025 D000003 0 025 D000004 0 025 D000005 0 025 D000006 0 025 D000007 0 PAGE 5 025 D000008 0 026 A000000 N 026 B000000 N 026 C000000 N 026 D000000 Y 026 E000000 N 026 F000000 N 026 G010000 N 026 G020000 N 026 H000000 N 027 000000 N 028 A010000 0 028 A020000 0 028 A030000 0 028 A040000 0 028 B010000 0 028 B020000 0 028 B030000 0 028 B040000 0 028 C010000 0 028 C020000 0 028 C030000 0 028 C040000 0 028 D010000 0 028 D020000 0 028 D030000 0 028 D040000 0 028 E010000 0 028 E020000 0 028 E030000 0 028 E040000 0 028 F010000 0 028 F020000 0 028 F030000 0 028 F040000 0 028 G010000 0 028 G020000 0 028 G030000 0 028 G040000 0 028 H000000 0 030 A000000 0 030 B000000 0.00 030 C000000 0.00 031 A000000 0 031 B000000 0 032 000000 0 033 000000 0 035 000000 0 036 B000000 0 038 000000 0 042 A000000 0 PAGE 6 042 B000000 0 042 C000000 0 042 D000000 0 042 E000000 0 042 F000000 0 042 G000000 0 042 H000000 0 043 000000 0 044 000000 0 045 000000 Y 046 000000 N 047 000000 N 048 000000 0.000 048 A010000 0 048 A020000 0.000 048 B010000 0 048 B020000 0.000 048 C010000 0 048 C020000 0.000 048 D010000 0 048 D020000 0.000 048 E010000 0 048 E020000 0.000 048 F010000 0 048 F020000 0.000 048 G010000 0 048 G020000 0.000 048 H010000 0 048 H020000 0.000 048 I010000 0 048 I020000 0.000 048 J010000 0 048 J020000 0.000 048 K010000 0 048 K020000 0.000 049 000000 N 050 000000 N 051 000000 N 052 000000 Y 053 A000000 Y 053 B000000 Y 053 C000000 N 054 A000000 Y 054 B000000 N 054 C000000 N 054 D000000 N 054 E000000 N 054 F000000 N 054 G000000 N 054 H000000 Y 054 I000000 N PAGE 7 054 J000000 Y 054 K000000 N 054 L000000 N 054 M000000 Y 054 N000000 N 054 O000000 Y 055 A000000 Y 055 B000000 N 056 000000 Y 057 000000 N 058 A000000 N 059 000000 Y 060 A000000 Y 060 B000000 Y 061 000000 0 062 A000000 N 062 B000000 0.0 062 C000000 0.0 062 D000000 0.0 062 E000000 0.0 062 F000000 0.0 062 G000000 0.0 062 H000000 0.0 062 I000000 0.0 062 J000000 0.0 062 K000000 0.0 062 L000000 0.0 062 M000000 0.0 062 N000000 0.0 062 O000000 0.0 062 P000000 0.0 062 Q000000 0.0 062 R000000 0.0 063 A000000 0 063 B000000 0.0 066 A000000 Y 066 B000000 N 066 C000000 N 066 D000000 N 066 E000000 Y 066 F000000 N 066 G000000 N 067 000000 N 068 A000000 N 068 B000000 N 069 000000 N 070 A010000 Y 070 A020000 Y 070 B010000 Y 070 B020000 Y 070 C010000 Y PAGE 8 070 C020000 N 070 D010000 Y 070 D020000 N 070 E010000 Y 070 E020000 N 070 F010000 Y 070 F020000 N 070 G010000 Y 070 G020000 N 070 H010000 Y 070 H020000 N 070 I010000 N 070 I020000 N 070 J010000 Y 070 J020000 Y 070 K010000 Y 070 K020000 Y 070 L010000 Y 070 L020000 Y 070 M010000 Y 070 M020000 N 070 N010000 Y 070 N020000 N 070 O010000 Y 070 O020000 N 070 P010000 N 070 P020000 N 070 Q010000 N 070 Q020000 N 070 R010000 Y 070 R020000 Y 071 A000000 811220 071 B000000 1330965 071 C000000 2164471 071 D000000 37 072 A000000 12 072 B000000 56232 072 C000000 77900 072 D000000 0 072 E000000 13021 072 F000000 19116 072 G000000 0 072 H000000 0 072 I000000 58 072 J000000 641 072 K000000 138 072 L000000 276 072 M000000 64 072 N000000 0 072 O000000 0 072 P000000 11870 PAGE 9 072 Q000000 0 072 R000000 40 072 S000000 69 072 T000000 0 072 U000000 0 072 V000000 0 072 W000000 2027 072 X000000 34299 072 Y000000 6519 072 Z000000 119373 072AA000000 0 072BB000000 348621 072CC010000 0 072CC020000 507757 072DD010000 140290 072DD020000 0 072EE000000 0 073 A010000 1.0040 073 A020000 0.0000 073 B000000 0.0000 073 C000000 0.0000 074 A000000 1455 074 B000000 19699 074 C000000 0 074 D000000 285382 074 E000000 610868 074 F000000 290965 074 G000000 0 074 H000000 0 074 I000000 16400 074 J000000 7181 074 K000000 0 074 L000000 10972 074 M000000 101744 074 N000000 1344666 074 O000000 5231 074 P000000 691 074 Q000000 0 074 R010000 0 074 R020000 5268 074 R030000 949 074 R040000 323258 074 S000000 165800 074 T000000 843469 074 U010000 139731 074 U020000 0 074 V010000 6.04 074 V020000 0.00 074 W000000 0.0000 074 X000000 335 074 Y000000 1196046 PAGE 10 075 A000000 0 075 B000000 1425575 076 000000 4.87 077 A000000 Y 077 B000000 Y 078 000000 N 080 A000000 CHUBB GROUP OF INSURANCE COMPANIES 080 B000000 AIG, GREAT AMERICAN, ST. PAUL & CNA 080 C000000 110000 081 A000000 Y 081 B000000 191 082 A000000 N 082 B000000 0 083 A000000 N 083 B000000 0 084 A000000 N 084 B000000 0 085 A000000 Y 085 B000000 N 086 A010000 0 086 A020000 0 086 B010000 39 086 B020000 427 086 C010000 0 086 C020000 0 086 D010000 32 086 D020000 799200 086 E010000 0 086 E020000 0 086 F010000 0 086 F020000 0 087 A010000 COMMON STOCK 087 A020000 67073D102 087 A030000 JQC 088 A000000 N 088 B000000 N 088 C000000 N 088 D000000 Y SIGNATURE STEPHEN D. FOY TITLE V.P & CONTROLLER